2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W097994
    DHMB 4055-69-0 98.67%
    DHMB (2,3-Dihydroxy-4-methoxybenzaldehyde) is a small organic molecule with anti-fungal and anti-inflammatory activity. DHMB has protective effect on intestinal epithelial cells.
    DHMB
  • HY-W440915
    DSPE-PEG2000-FITC 1000788-53-3 99.76%
    DSPE-PEG2000-FITC is a PEG lipid conjugated with fluorescein. FITC is a green dye with a peak absorption at 494 nm and a maximum emission at 520 nm, which is used for staining biological samples or nanoparticles. DSPE-PEG2000-FITC spontaneously forms lipid bilayers or micelles in water and can be used to prepare liposomes for delivering substances such as mRNA vaccines.
    DSPE-PEG2000-FITC
  • HY-W442049
    Hydroxypinacolone retinoate 893412-73-2 99.33%
    Hydroxypinacolone retinoate (HPR) is a retinol derivative, which binds directly with retinoic acid receptors (RARs). Hydroxypinacolone retinoate, when used in combination with Retinyl propionate, can be used in anti-skin aging research.
    Hydroxypinacolone retinoate
  • HY-W709553
    Glyceryl Triformate 32765-69-8
    Glyceryl Triformate (Triglyceride) is the major form of storage and transport of fatty acids within cells and in the plasma. Glyceryl Triformate forms lipoproteins with cholesterol ester, and participates in the blood circulation. Glyceryl Triformate can lead to hypertriglyceridemia (HTG), which increases the risk of atherosclerotic cardiovascular disease (ASCVD) and pancreatitis.
    Glyceryl Triformate
  • HY-W011927R
    4,4'-Sulfonyldiphenol (Standard) 80-09-1 99.33%
    4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) (Standard) is the analytical standard of 4,4'-Sulfonyldiphenol (HY-W011927). This product is intended for research and analytical applications. 4,4'-Sulfonyldiphenol, a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.
    4,4'-Sulfonyldiphenol (Standard)
  • HY-101041
    (E)-AG 556 133550-41-1 99.91%
    (E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production.
    (E)-AG 556
  • HY-115532
    BCL6-IN-7 2097518-46-0 99.79%
    BCL6-IN-7 is a potent BCL6−corepressor interaction inhibitor.
    BCL6-IN-7
  • HY-101766
    Btk inhibitor 2 1558036-85-3 99.53%
    Btk inhibitor 2 is a Bruton's tyrosine kinase (BTK) inhibitor extracted from patent US 20170224688 A1.
    Btk inhibitor 2
  • HY-177080
    Emvistegrast 2417352-91-9 98.06%
    Emvistegrast (GS-1427) is a quinolone derivative. Emvistegrast is also an inhibitor of α4β7 integrin. Emvistegrast can be used to investigate diseases mediated by α4β7 integrin, such as inflammatory bowel disease.
    Emvistegrast
  • HY-101588A
    Gefapixant citrate 2310299-91-1 99.23%
    Gefapixant citrate is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant citrate can be used for the research of chronic cough and knee osteoarthritis.
    Gefapixant citrate
  • HY-17589AS
    Chloroquine-d5 1854126-41-2 ≥99.0%
    Chloroquine-d5 is deuterium labeled Chloroquine (HY-17589A). Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).
    Chloroquine-d5
  • HY-P990773
    Venanprubart 2635407-50-8 98.00%
    Venanprubart is an anti-BTLA human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
    Venanprubart
  • HY-12946
    BI 653048 1198784-72-3 99.84%
    BI 653048, a chemical probe, is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM. BI 653048 inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM). BI 653048 (Compound 103) is also a HCV NS3 protease inhibitor that can reduce viral loads infected with the hepatitis C virus.
    BI 653048
  • HY-A0191
    Dexbrompheniramine 132-21-8 99.93%
    Dexbrompheniramine ((+)-Brompheniramine; (S)-Brompheniramine) is a dual inhibitor of histamine H1 receptor and TRPV1 receptor that can cross the blood-brain barrier. Dexbrompheniramine exerts its effects by functionally blocking H1 receptor activity and dose-dependently inhibiting TRPV1-mediated calcium responses, including Capsaicin (HY-10448)-induced responses. The combination of Dexbrompheniramine with Cimetidine (HY-14289) eliminates histamine-induced and sham-feeding-induced drinking behavior, whereas Dexbrompheniramine alone does not induce thirst or alter sham-feeding behavior in rats. Dexbrompheniramine can be used in the research of chronic cough and related pathological mechanisms.
    Dexbrompheniramine
  • HY-P3412
    MMI-0100 1039342-24-9 98.83%
    MMI-0100 is a cell-permeant peptide inhibitor of mitogen activated protein kinase activated protein kinase II (MK2). MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-0100 suppresses fibrotic processes such as vein graft disease.
    MMI-0100
  • HY-103039
    TLR7 agonist 2 1642857-69-9 98.80%
    TLR7 agonist 2 is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a LEC of 0.4 μM.
    TLR7 agonist 2
  • HY-107980
    DS28120313 2146177-09-3 98.00%
    DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM.
    DS28120313
  • HY-109093
    Linzagolix 935283-04-8 99.68%
    Linzagolix (KLH-2109; OBE-2109) is a potent, non-peptide, and orally active GnRH antagonist. Linzagolix can be used for uterine fibroids, endometriosis, adenomyosis research.
    Linzagolix
  • HY-109096
    Nidufexor 1773489-72-7 99.67%
    Nidufexor (LMB763) is an orally-available farnesoid X receptor (FXR) agonist for the research of nonalcoholic steatohepatitis (NASH).
    Nidufexor
  • HY-109105
    Tepilamide fumarate 1208229-58-6 99.77%
    Tepilamide fumarate (XP-23829; PPC-06) is an oral fumaric acid ester, acts as a proagent ofMonomethyl fumarate (HY-103252), and is used in the research of moderate to severe chronic plaque psoriasis. Tepilamide fumarate can enhance the effectiveness of oncolytic viruses.
    Tepilamide fumarate
Cat. No. Product Name / Synonyms Application Reactivity