2. (E)-AG 556

(E)-AG 556  (Synonyms: (E)-Tyrphostin AG 556)

Cat. No.: HY-101041 Purity: 99.92%
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(E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production.

For research use only. We do not sell to patients.

(E)-AG 556 Chemical Structure

(E)-AG 556 Chemical Structure

CAS No. : 133550-41-1

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 In-stock
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Solid
5 mg USD 60 In-stock
10 mg USD 100 In-stock
25 mg USD 200 In-stock
50 mg USD 300 In-stock
100 mg   Get quote  
200 mg   Get quote  

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(E)-AG 556 Related Antibodies

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Description

(E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production[1][2].

Molecular Weight

336.39

Formula

C20H20N2O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NCCCCC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (297.27 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9727 mL 14.8637 mL 29.7274 mL
5 mM 0.5945 mL 2.9727 mL 5.9455 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9727 mL 14.8637 mL 29.7274 mL 74.3185 mL
5 mM 0.5945 mL 2.9727 mL 5.9455 mL 14.8637 mL
10 mM 0.2973 mL 1.4864 mL 2.9727 mL 7.4318 mL
15 mM 0.1982 mL 0.9909 mL 1.9818 mL 4.9546 mL
20 mM 0.1486 mL 0.7432 mL 1.4864 mL 3.7159 mL
25 mM 0.1189 mL 0.5945 mL 1.1891 mL 2.9727 mL
30 mM 0.0991 mL 0.4955 mL 0.9909 mL 2.4773 mL
40 mM 0.0743 mL 0.3716 mL 0.7432 mL 1.8580 mL
50 mM 0.0595 mL 0.2973 mL 0.5945 mL 1.4864 mL
60 mM 0.0495 mL 0.2477 mL 0.4955 mL 1.2386 mL
80 mM 0.0372 mL 0.1858 mL 0.3716 mL 0.9290 mL
100 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.7432 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E)-AG 556133550-41-1(E)-Tyrphostin AG 556Inhibitorinhibitorinhibit

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