133550-41-1
133550-41-1
Chemical Structure
(E)-AG 556
Synonym(s): (E)-Tyrphostin AG 556
- CAS No.: 133550-41-1
- Formula:C20H20N2O3
- Molecular Weight:336.39
IUPAC Name: (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)acrylamide
InChIKey: GWCNJMUSWLTSCW-SFQUDFHCSA-N
SMILES: O=C(NCCCCC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2
Biological Activity: (E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(E)-AG 556 | 99.91% | (E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production. | ||||||||||||||||||||
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References
- [1]. Gazit A, et al. Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J Med Chem. 1991 Jun;34(6):1896-907. [Content Brief]
- [2]. George J, et al. Tyrphostin AG-556 reduces myocardial infarct size and improves cardiac performance in the rat. Exp Mol Pathol. 2003 Jun;74(3):314-8. [Content Brief]
