Lithium 2-hydroxypropanoate
Based on 44 publication(s) in Google Scholar
Lithium 2-hydroxypropanoate is a lithium salt. Lithium 2-hydroxypropanoate has immunomodulatory activity (slightly enhancing PHA (HY-N7038)-induced lymphocyte proliferation). Lithium 2-hydroxypropanoate can be used in antioxidant activity assays. Lithium 2-hydroxypropanoate can be used in the research of mental diseases.
For research use only. We do not sell to patients.
- Purity: 99.80%
- CAS No.: 867-55-0
- Formula: C3H5LiO3
- Molecular Weight:96.01
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Lithium 2-hydroxypropanoate
More- Bioact Mater. 2024 Jun 24:40:445-459. [Abstract]
- Nat Commun. 2025 Dec 12. [Abstract]
- J Adv Res. 2025 May 13:S2090-1232(25)00351-0. [Abstract]
- Redox Biol. 2025 Apr:81:103553. [Abstract]
- MedComm (2020). 2025 Aug 29;6(9):e70344. [Abstract]
- Adv Sci (Weinh). 2025 Jul 29:e09477. [Abstract]
- Adv Sci (Weinh). 2024 May 20:e2307216. [Abstract]
- Cell Death Differ. 2025 Sep 23. [Abstract]
- Research (Wash D C). 2025 May 30:8:0705. [Abstract]
- Cell Death Dis. 2025 Feb 28;16(1):144. [Abstract]
- Int J Biol Sci. 2025 Apr 22;21(7):3061-3080. [Abstract]
- Clin Cancer Res. 2026 Apr 17. [Abstract]
- J Transl Med. 2025 Aug 18;23(1):923. [Abstract]
- Cell Rep. 2025 Jul 30;44(8):116091. [Abstract]
- J Ginseng Res. 2024 May;48(3):298-309. [Abstract]
- J Agric Food Chem. 2026 Jun 24;74(24):18768-18778. [Abstract]
- J Agric Food Chem. 2025 Dec 17;73(50):32236-32249. [Abstract]
- Ecotoxicol Environ Saf. 2025 Nov 15:307:119451. [Abstract]
- Biochem Pharmacol. 2026 Mar 20:249:117918. [Abstract]
- RSC Adv. 2026 May 18;16(21):19511-19523. [Abstract]
- Cancer Metab. 2026 Apr 2;14(1):13. [Abstract]
- Commun Biol. 2025 Nov 20;8(1):1626. [Abstract]
- Commun Biol. 2025 Jul 8;8(1):1020. [Abstract]
- Cancer Immunol Immunother. 2024 Oct 3;73(12):254. [Abstract]
- Respir Res. 2024 Nov 9;25(1):401. [Abstract]
- Sci Rep. 2026 May 25. [Abstract]
- Food Qual Saf. 2025 Aug 4.
- Cell Signal. 2026 Jun 27:112701. [Abstract]
- J Cell Mol Med. 2025 Jul;29(13):e70692. [Abstract]
- J Cell Mol Med. 2025 Jun;29(12):e70669. [Abstract]
- Brain Res Bull. 2025 May:224:111292. [Abstract]
- FASEB J. 2026 May 15;40(9):e71765. [Abstract]
- FASEB J. 2026 Feb 15;40(3):e71547. [Abstract]
- Ren Fail. 2026 Dec;48(1):2630507. [Abstract]
- Vet Res. 2025 Apr 30;56(1):94. [Abstract]
- J Integr Neurosci. 2025 Feb 25;24(2):25949. [Abstract]
- Exp Eye Res. 2026 Jun:267:110981. [Abstract]
- Kaohsiung J Med Sci. 2025 Nov 13:e70123. [Abstract]
- Tissue Cell. 2024 Jul 9:89:102468. [Abstract]
- J Cardiovasc Transl Res. 2025 Sep 8. [Abstract]
- Biochem Biophys Res Commun. 2025 Sep 8:778:152379. [Abstract]
- Genes Genomics. 2025 May;47(5):521-531. [Abstract]
- Res Sq. 2026 Jun 15.
- bioRxiv. 2026 Mar 10.
Customer Validation & Images
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WB
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WB
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RT-PCR
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IP
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RT-PCR
Biological Activity
Lithium 2-hydroxypropanoate (0.6 μmol/mL (as Li+), 72 h) has no significant effect on the proliferation rate of lymphocytes without PHA stimulation, but slightly increases the proliferation rate of lymphocytes induced by PHA (HY-N7038) (92% compared with 87% in the control group)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 867-55-0
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Appearance Solid
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Molecular Weight 96.01
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Formula C3H5LiO3
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Color White to off-white
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SMILES
CC(O)C(O[Li])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (44)
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Journal Impact Factor
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Most Recent
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Bioact Mater
Concerting magnesium implant degradation facilitates local chemotherapy in tumor-associated bone defect. [Abstract]2024 Jun 24:40:445-459. PMID: 39027327 -
Nat Commun
Hyperglycemia exacerbates osteoarthritis by impairing macrophage efferocytosis through modulation of CD11b lactylation. [Abstract]2025 Dec 12. PMID: 41387463 -
J Adv Res
Targeting mesenchymal monocyte-derived macrophages to enhance the sensitivity of glioblastoma to temozolomide by inhibiting TNF/CELSR2/p65/Kla-HDAC1/EPAS1 axis. [Abstract]2025 May 13:S2090-1232(25)00351-0. PMID: 40373963 -
Redox Biol
Histone lactylation drives liver cancer metastasis by facilitating NSF1-mediated ferroptosis resistance after microwave ablation. [Abstract]2025 Apr:81:103553. PMID: 39970777
Lithium 2-hydroxypropanoate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Apr:81:103553. [Abstract]
Immunoblot and quantification analyses of NFS1 in HCC cells incubated with 0, 5, or 10 mM lactate after being subjected to either a 47 °C or 37 °C water bath.
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MedComm (2020)
Global Lactylome Reveals Lactylation-Dependent Mechanisms Underlying CXC Motif Chemokine Ligand 12 Expression in Pulmonary Endothelium During Acute Respiratory Distress Syndrome. [Abstract]2025 Aug 29;6(9):e70344. PMID: 40895187 -
Adv Sci (Weinh)
ASH2L-K312-Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma. [Abstract]2025 Jul 29:e09477. PMID: 40726441
Lithium 2-hydroxypropanoate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 29:e09477. [Abstract]
Following the direct addition of lactic acid (a final concentration of 100 mM) to the culture medium for 12 h, western blotting, and immunoprecipitation assays revealed a significant increase in the total lactylation and corresponding lysine-312 lactylation levels in ASH2L
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Adv Sci (Weinh)
Histone H3K18 and Ezrin Lactylation Promote Renal Dysfunction in Sepsis-Associated Acute Kidney Injury. [Abstract]2024 May 20:e2307216. PMID: 38767134 -
Cell Death Differ
AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy. [Abstract]2025 Sep 23. PMID: 40987895 -
Research (Wash D C)
Lactate-Induced Mitochondrial Calcium Uptake 3 Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting Neutrophil Extracellular Trap Formation. [Abstract]2025 May 30:8:0705. PMID: 40452820 -
Cell Death Dis
Lactylation-driven transcriptional activation of FBXO33 promotes gallbladder cancer metastasis by regulating p53 polyubiquitination. [Abstract]2025 Feb 28;16(1):144. PMID: 40021626
Lithium 2-hydroxypropanoate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Feb 28;16(1):144. [Abstract]
Lactate (25 mM) significantly increases the mRNA and protein expression of FBXO33.
Lithium 2-hydroxypropanoate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2025 Feb 28;16(1):144. [Abstract]
Co-IP detected the effect of lactate on YY1 protein lactylation modification.
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Int J Biol Sci
Macrophage-derived S100A9 promotes diabetic cardiomyopathy by disturbing mitochondrial quality control via STAT3 activation. [Abstract]2025 Apr 22;21(7):3061-3080. PMID: 40384874 -
Clin Cancer Res
Lactate-induced lactylation enhances BMAL1 transcription and nuclear translocation, promoting bevacizumab resistance in glioblastoma through VEGFA. [Abstract]2026 Apr 17. PMID: 41995718 -
J Transl Med
Metabolic interplay between endometrial cancer and tumor-associated macrophages: lactate-induced M2 polarization enhances tumor progression. [Abstract]2025 Aug 18;23(1):923. PMID: 40826409 -
Cell Rep
TRIM65 as a key regulator of ferroptosis and glycolysis in lactate-driven renal tubular injury and diabetic kidney disease. [Abstract]2025 Jul 30;44(8):116091. PMID: 40748757 -
J Ginseng Res
20(S)-ginsenoside Rh2 ameliorates ATRA resistance in APL by modulating lactylation-driven METTL3. [Abstract]2024 May;48(3):298-309. PMID: 38707638
Lithium 2-hydroxypropanoate purchased from MedChemExpress. Usage Cited in: J Ginseng Res. 2024 May;48(3):298-309. [Abstract]
The expression level of METTL3, YTHDF1, YTHDF2, and YTHDC1 in NB4-R1 and NB4-R2 cells treated with 20 μM oxamate or 20 μM lactate or 1 μM ATRA for 48 h was detected via qRT-PCR.
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J Agric Food Chem
Dietary Lactic Acid Attenuates Ovalbumin-Induced Food Allergy in Mice via Orchestrating Dendritic Cell and T Cell Immune Tolerance. [Abstract]2026 Jun 24;74(24):18768-18778. PMID: 42287222 -
J Agric Food Chem
Lactic Acid Alleviates Cow's Milk Allergy by Regulating Regulatory T Cells and Intestinal Microbiota. [Abstract]2025 Dec 17;73(50):32236-32249. PMID: 41359930 -
Ecotoxicol Environ Saf
MC-LR triggers trophoblast ferroptosis at the maternal-fetal interface by directly targeting PKM2 to reprogram metabolism. [Abstract]2025 Nov 15:307:119451. PMID: 41273830 -
Biochem Pharmacol
CSDE1-mediated histone lactylation modification of the HOXD9 promoter promotes gastric cancer progression. [Abstract]2026 Mar 20:249:117918. PMID: 41864431 -
RSC Adv
Inducible secretion of LIGHT by engineered probiotics enables localized cytokine therapy and robust antitumor immunity. [Abstract]2026 May 18;16(21):19511-19523. PMID: 42157872 -
Cancer Metab
PER2 knockdown drives immunotherapy resistance in gastric cancer via metabolic reprogramming of myeloid-derived suppressor cells. [Abstract]2026 Apr 2;14(1):13. PMID: 41928364 -
Commun Biol
Deoxynivalenol induces ferroptosis via inhibiting glycolysis-H3K18la-STEAP3 axis to promote ovary damage in piglets. [Abstract]2025 Nov 20;8(1):1626. PMID: 41266595 -
Commun Biol
CAF-derived GLUT1 and its role in modulating ovarian cancer progression: a multi-dimensional analysis of the tumor microenvironment. [Abstract]2025 Jul 8;8(1):1020. PMID: 40629043 -
Cancer Immunol Immunother
2024 Oct 3;73(12):254. PMID: 39358478 -
Respir Res
Lactate activates ER stress to promote alveolar epithelial cells apoptosis in pulmonary fibrosis. [Abstract]2024 Nov 9;25(1):401. PMID: 39522031 -
Sci Rep
Integrating single-cell and bulk transcriptomic analyses to explore key lactylation-related genes in benign prostatic hyperplasia. [Abstract]2026 May 25. PMID: 42185567 -
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Cell Signal
PDK4-dependent lactate production and lactylation promote renal calcium oxalate crystal-induced EMT and mitochondrial dysfunction via the TGF-β/SMAD3/GPX4 axis. [Abstract]2026 Jun 27:112701. PMID: 42364861 -
J Cell Mol Med
Identification of LDHA as a Potential Therapeutic Target for Pulmonary Hypertension Through Modulation of Endothelial-To-Mesenchymal Transition. [Abstract]2025 Jul;29(13):e70692. PMID: 40629253 -
J Cell Mol Med
Lactylation-Related Gene LILRB4 Predicts the Prognosis and Immunotherapy of Prostate Cancer Based on Machine Learning. [Abstract]2025 Jun;29(12):e70669. PMID: 40576161 -
Brain Res Bull
LDHA enhances brain injury and apoptosis after intracerebral hemorrhage by promoting P53 transcription through increasing P53 lactylation. [Abstract]2025 May:224:111292. PMID: 40057050 -
FASEB J
Lactate-Driven Epigenetic Reprogramming of Osteogenesis: H3K18 Lactylation Activates m6A/YTHDF1-Dependent YAP1 Signaling to Combat Bone Loss. [Abstract]2026 May 15;40(9):e71765. PMID: 42033168 -
FASEB J
Limonin Is a Novel Hexokinase 2 Inhibitor That Suppresses Hepatic Stellate Cell Activation and Histone Lactylation. [Abstract]2026 Feb 15;40(3):e71547. PMID: 41649270 -
Ren Fail
Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidation. [Abstract]2026 Dec;48(1):2630507. PMID: 41808346 -
Vet Res
Neospora caninum hijacks host PFKFB3-driven glycolysis to facilitate intracellular propagation of parasites. [Abstract]2025 Apr 30;56(1):94. PMID: 40307939 -
J Integr Neurosci
2025 Feb 25;24(2):25949. PMID: 40018779 -
Exp Eye Res
Aqueous humor levels of H3K18 lactylation and IL-1β reflect epigenetic-inflammatory activation in lens epithelium and serve as novel potential biomarkers for cataract diagnosis. [Abstract]2026 Jun:267:110981. PMID: 41864487 -
Kaohsiung J Med Sci
Hypoxia-Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via the Wnt/β-Catenin Pathway. [Abstract]2025 Nov 13:e70123. PMID: 41229334 -
Tissue Cell
Gegen Qinlian decoction inhibited M1 macrophage polarization and ulcerative colitis progression through regulating histone lactylation. [Abstract]2024 Jul 9:89:102468. PMID: 39003913 -
J Cardiovasc Transl Res
Hypoxia Aggravates Myocardial Ischemia/Reperfusion Injury Through the Promotion of Ferroptosis via ACSL4 Lactylation. [Abstract]2025 Sep 8. PMID: 40920282 -
Biochem Biophys Res Commun
Hsp60 lactylation promotes mitochondrial dysfunction and trophoblast apoptosis in preeclampsia. [Abstract]2025 Sep 8:778:152379. PMID: 40694902 -
Genes Genomics
Lactate released by lung adenocarcinoma (LUAD) cells promotes M2 macrophage polarization via the GPR132/cAMP/PKA pathway. [Abstract]2025 May;47(5):521-531. PMID: 40053234 -
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Solvent & Solubility
DMSO : 10 mg/mL (104.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 5.83 mg/mL (60.72 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 10.4156 mL | 52.0779 mL | 104.1558 mL | 260.3895 mL |
| 5 mM | 2.0831 mL | 10.4156 mL | 20.8312 mL | 52.0779 mL | |
| 10 mM | 1.0416 mL | 5.2078 mL | 10.4156 mL | 26.0390 mL | |
| 15 mM | 0.6944 mL | 3.4719 mL | 6.9437 mL | 17.3593 mL | |
| 20 mM | 0.5208 mL | 2.6039 mL | 5.2078 mL | 13.0195 mL | |
| 25 mM | 0.4166 mL | 2.0831 mL | 4.1662 mL | 10.4156 mL | |
| 30 mM | 0.3472 mL | 1.7359 mL | 3.4719 mL | 8.6797 mL | |
| 40 mM | 0.2604 mL | 1.3019 mL | 2.6039 mL | 6.5097 mL | |
| 50 mM | 0.2083 mL | 1.0416 mL | 2.0831 mL | 5.2078 mL | |
| 60 mM | 0.1736 mL | 0.8680 mL | 1.7359 mL | 4.3398 mL | |
| DMSO | 80 mM | 0.1302 mL | 0.6510 mL | 1.3019 mL | 3.2549 mL |
| 100 mM | 0.1042 mL | 0.5208 mL | 1.0416 mL | 2.6039 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Lithium 2-hydroxypropanoate Related Classifications
HY-W010625 Related Classifications
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