BCL6-IN-7
Based on 1 Customer Validation
BCL6-IN-7 is a potent BCL6−corepressor interaction inhibitor.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 2097518-46-0
- Formula: C18H15ClN6O
- Molecular Weight:366.80
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DOHH-2 | IC50 |
47.6 μM
Compound: 3
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Antiproliferative activity against human DOHH2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human DOHH2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 31895575] |
| Farage | IC50 |
33.5 μM
Compound: 3
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Antiproliferative activity against human Farage cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human Farage cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 31895575] |
| HEK-293T | IC50 |
8.6 μM
Compound: 7
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Inhibition of VP16 activation domain-fused human BCOR (112 to 753 amino acid residues) binding to GAL4 DNA binding domain-fused wild-type human BCL6 (5 to 129 amino acid residues) expressed in HEK293T cell lysates after 20 hrs by firefly luciferase assay
Inhibition of VP16 activation domain-fused human BCOR (112 to 753 amino acid residues) binding to GAL4 DNA binding domain-fused wild-type human BCL6 (5 to 129 amino acid residues) expressed in HEK293T cell lysates after 20 hrs by firefly luciferase assay
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[PMID: 28471657] |
| L02 | IC50 |
>100 μM
Compound: 3
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Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 31895575] |
| NCM460 | IC50 |
>100 μM
Compound: 3
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Cytotoxicity against human NCM460 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Cytotoxicity against human NCM460 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 31895575] |
| OCI-Ly7 | IC50 |
33.9 μM
Compound: 3
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Antiproliferative activity against human OCI-LY7 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human OCI-LY7 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 31895575] |
| PNT1A | IC50 |
>100 μM
Compound: 3
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Cytotoxicity against human PNT1A cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Cytotoxicity against human PNT1A cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 31895575] |
| Sf9 | IC50 |
2699 nM
Compound: 1
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Inhibition FITC-labeled BCoR peptide binding to wild type human BCL6 BTB domain (5 to 129 residues) expressed in baculovirus infected Sf9 cells after 30 mins by TR-FRET assay
Inhibition FITC-labeled BCoR peptide binding to wild type human BCL6 BTB domain (5 to 129 residues) expressed in baculovirus infected Sf9 cells after 30 mins by TR-FRET assay
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[PMID: 32551010] |
| SUD4 | IC50 |
24.3 μM
Compound: 3
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Antiproliferative activity against human SUDHL4 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human SUDHL4 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 31895575] |
| Toledo | IC50 |
39.5 μM
Compound: 3
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Antiproliferative activity against BCL6-negative human Toledo cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against BCL6-negative human Toledo cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
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[PMID: 31895575] |
Chemical Information
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CAS No. 2097518-46-0
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Appearance Solid
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Molecular Weight 366.80
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Formula C18H15ClN6O
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Color White to off-white
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SMILES
O=C1NC2=C(C=C(NC3=NC(NCC4=CC=CN=C4)=NC=C3Cl)C=C2)C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 5 mg/mL (13.63 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7263 mL | 13.6314 mL | 27.2628 mL | 68.1570 mL |
| 5 mM | 0.5453 mL | 2.7263 mL | 5.4526 mL | 13.6314 mL | |
| 10 mM | 0.2726 mL | 1.3631 mL | 2.7263 mL | 6.8157 mL |
BCL6-IN-7 Related Classifications
HY-115532 Related Classifications
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