2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P992151
    Sphingomab 98%
    Sphingomab (LT1002) is a mouse-derived IgG1 κ monoclonal antibody and also an inhibitor targeting S1P, with high affinity for S1P and a Kd value of 0.03 ± 0.002 nM. Sphingomab blocks S1P-mediated IL-8 release in ovarian cancer cells. Sphingomab exhibits anti-angiogenic activity in a mouse model of choroidal neovascularization. Sphingomab reduces peripheral blood lymphocyte counts. Sphingomab can be used in the research of ovarian cancer and age-related macular degeneration.
    Sphingomab
  • HY-P992159
    Anti-ZnT8 Antibody (mAb43) 98%
    Anti-ZnT8 Antibody (mAb43) is a monoclonal antibody targeting the zinc transporter ZnT8, with islet-specific biodistribution characteristics. Anti-ZnT8 Antibody (mAb43) binds to extracellular ZnT8 on the surface of pancreatic β-cells and masks its insulin-co-localizing sites to block autoimmune recognition. Anti-ZnT8 Antibody (mAb43) also promotes an increase in the proportion of regulatory T cells and inhibits B cell antigen presentation, thereby effectively blocking the T cell-mediated cascade of β-cell destruction. Anti-ZnT8 Antibody (mAb43) eliminates insulitis, preserves β-cell mass and induces seroconversion of autoantibodies, without directly altering the insulin secretion function or content of β-cells. Anti-ZnT8 Antibody (mAb43) can be used for research related to type 1 diabetes.
    Anti-ZnT8 Antibody (mAb43)
  • HY-P992242
    Anti-IL-23R Antibody 98%
    Anti-IL-23R Antibody is a monoclonal antibody that targets IL-23R. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-23R Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-IL-23R Antibody
  • HY-P99226A
    Daxdilimab (FUT8-KO)
    Daxdilimab (FUT8-KO) is an anti-ILT7 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the antibody-dependent cellular cytotoxicity (ADCC) effect of the antibody.
    Daxdilimab (FUT8-KO)
  • HY-P992474
    TAVO101 98%
    TAVO101 is a humanized anti-TSLP antibody with an EC50 of 0.19 nM against hTSLP. TAVO101 inhibits STAT5 activation and CCL17 release. TAVO101 carries Fc region mutations that enhance its binding to FcRn while reducing its binding to FcγRI, FcγRIIIA and C1q, thereby attenuating effector functions. TAVO101 reduces the levels of inflammatory markers, cell infiltration and histopathological damage in preclinical models of asthma, psoriasis and atopic dermatitis. TAVO101 can be used for research related to asthma, psoriasis and atopic dermatitis.
    TAVO101
  • HY-W000701
    Isourolithin A 174023-48-4 98.08%
    Isourolithin A (Iso-uroA) is a flavonoid compound. Isourolithin A is applicable to anti-inflammatory and antioxidant research.
    Isourolithin A
  • HY-W001251
    3,5-Dimethoxybenzoic acid 1132-21-4
    3,5-Dimethoxybenzoic acid is an aromatic organic acid and antifungal agent. 3,5-Dimethoxybenzoic acid can also be used as an intermediate for anticancer agents. 3,5-Dimethoxybenzoic acid can be isolated from the leaves of Melia azedarach. 3,5-Dimethoxybenzoic acid exhibits antifungal activity against A. rabiei with an MIC of 0.125 mg/mL. 3,5-Dimethoxybenzoic acid has anti-wrinkle, anti-inflammatory, antioxidant, and skin regeneration effects.
    3,5-Dimethoxybenzoic acid
  • HY-W002484
    3-Hydroxy-4-methoxyacetophenone 6100-74-9 99.37%
    3-Hydroxy-4-methoxyacetophenone(Acetoisovanillone; Isoacetovanillone) is an active compound isolated from P. spinosa. Isoacetovanillone possesses anti-inflammatory activity and prevented injuries due to administration of acetic acid in the colon.
    3-Hydroxy-4-methoxyacetophenone
  • HY-W005767
    2,3-Dimethylhydroquinone 608-43-5
    2,3-Dimethylhydroquinone (o-Xylohydroquinone) is a hydroquinone. 2,3-Dimethylhydroquinone can be oxidized by Myeloperoxidase. 2,3-Dimethylhydroquinone can be used in the research of inflammatory diseases.
    2,3-Dimethylhydroquinone
  • HY-W010243
    Methylisothiazolinone hydrochloride 26172-54-3
    Methylisothiazolinone hydrochloride is a bacterial and fungal inhibitor and preservative, as well as a sensitizer. Methylisothiazolinone hydrochloride can activate matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce apoptosis and inflammatory response. Methylisothiazolinone hydrochloride can promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses. Methylisothiazolinone hydrochloride can cause mitochondrial damage in the endothelium of rat cerebral blood vessels.
    Methylisothiazolinone hydrochloride
  • HY-W011592
    N-Phthaloyl-L-glutamic acid 340-90-9 98%
    N-Phthaloyl-L-glutamic acid is an orally active anti-inflammatory agent. N-Phthaloyl-L-glutamic acid inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced nitric oxide production in murine spleen cells. N-Phthaloyl-L-glutamic acid does not exhibit significant cytotoxicity in vitro against tumor cells and BALB/c mice spleen cell culture. N-Phthaloyl-L-glutamic acid can be used for the research of inflammation.
    N-Phthaloyl-L-glutamic acid
  • HY-W011733
    Tulobuterol hydrochloride 56776-01-3 99.83%
    Tulobuterol hydrochloride (C-78) is a long-acting β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma. Tulobuterol hydrochloride is also a sympathomimetic agent used as a transdermal patch, increases normal diaphragm muscle strength. Tulobuterol hydrochloride inhibit rhinovirus replication and modulate airway inflammation.
    Tulobuterol hydrochloride
  • HY-W011954
    Isopentyl 3-(4-methoxyphenyl)acrylate 71617-10-2 99.58%
    Isopentyl 3-(4-methoxyphenyl)acrylate, a derivative of cinnamon acid ester, is a UV-filter with anti-inflammatory activity.
    Isopentyl 3-(4-methoxyphenyl)acrylate
  • HY-W012092
    Ethyl 3,4,5-trimethoxybenzoate 6178-44-5 99.67%
    Ethyl 3,4,5-trimethoxybenzoate is a melanogenesis inhibitor. Ethyl 3,4,5-trimethoxybenzoate does not directly target tyrosinase activity, but inhibits melanin synthesis in a dose-dependent manner by downregulating α-MSH (HY-P0252)-induced tyrosinase protein expression and scavenging ROS. Ethyl 3,4,5-trimethoxybenzoate scavenges DPPH free radicals. Ethyl 3,4,5-trimethoxybenzoate can be used in the research of hyperpigmentation.
    Ethyl 3,4,5-trimethoxybenzoate
  • HY-W014606
    L-Lysine acetate 57282-49-2 98.0%
    L-Lysine acetate is an essential amino acid. L-Lysine acetate can be research for vascular calcification (VC) and Acute pancreatitis.
    L-Lysine acetate
  • HY-W015627
    3,5-Dichloropyridine 2457-47-8 99.97%
    3,5-dichloropyridine is a drug intermediate that can be used to synthesize metal-organic framework (MOF) materials and P2X7 receptor antagonists.
    3,5-Dichloropyridine
  • HY-W015811
    3-N-Propylphenol 621-27-2 98.49%
    3-N-Propylphenol is a small phenolic derivative containing a hydroxyl aryl group that competitively inhibits the binding of the peptide to pancreatic-specific protein disulfide isomerase (PDIp). 3-Propylphenol can be used for research on pancreatic-related diseases.
    3-N-Propylphenol
  • HY-W017428
    4-Ethoxybenzaldehyde 10031-82-0 99.67%
    4-Ethoxybenzaldehyde (P-Ethyoxybenzaldehyde) is a derivative of benzaldehyde. 4-Ethoxybenzaldehyde can significantly inhibit the production of key inflammatory factors such as prostaglandin E2 (PGE2), IL-6, and IL-8 induced by ultraviolet radiation (UVR). 4-Ethoxybenzaldehyde shows significant efficacy and good safety in reducing facial redness when added to an oil-in-water emulsion at a concentration of 1%. 4-Ethoxybenzaldehyde can be used in the study of chronic inflammatory skin diseases.
    4-Ethoxybenzaldehyde
  • HY-W025736
    5-Amino-2-methoxyphenol 1687-53-2 98%
    5-Amino-2-methoxyphenol is a phenolic regioisomer. 5-Amino-2-methoxyphenol produces dose-dependent antinociception in the mouse formalin test, with its second-phase effect being mechanistically dependent on both FAAH and TRPV1. 5-Amino-2-methoxyphenol can be used for antinociception research.
    5-Amino-2-methoxyphenol
  • HY-W028047
    JFD01307SC 51070-56-5 98.0%
    JFD01307SC is a glutamine synthetase inhibitor and anti-tuberculosis agent. JFD01307SC acts as a mimic of L-Glutamate and thus target enzymes involved in glutamine biosynthesis.
    JFD01307SC
Cat. No. Product Name / Synonyms Application Reactivity