2,3-Dimethylhydroquinone
Based on 1 Customer Validation
2,3-Dimethylhydroquinone (o-Xylohydroquinone) is a hydroquinone. 2,3-Dimethylhydroquinone can be oxidized by Myeloperoxidase. 2,3-Dimethylhydroquinone can be used in the research of inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 608-43-5
- Formula: C8H10O2
- Molecular Weight:138.16
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U-251 | EC50 |
17 μM
Compound: 6
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Antiproliferative activity against human U251MG cells after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human U251MG cells after 72 hrs by sulforhodamine B assay
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[PMID: 30568753] |
Chemical Information
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CAS No. 608-43-5
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Appearance Solid
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Molecular Weight 138.16
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Formula C8H10O2
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SMILES
CC(C(O)=CC=C1O)=C1C
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Synonyms
o-Xylohydroquinone
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 50 mg/mL (361.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (18.09 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (18.09 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.2380 mL | 36.1899 mL | 72.3798 mL | 180.9496 mL |
| 5 mM | 1.4476 mL | 7.2380 mL | 14.4760 mL | 36.1899 mL | |
| 10 mM | 0.7238 mL | 3.6190 mL | 7.2380 mL | 18.0950 mL | |
| 15 mM | 0.4825 mL | 2.4127 mL | 4.8253 mL | 12.0633 mL | |
| 20 mM | 0.3619 mL | 1.8095 mL | 3.6190 mL | 9.0475 mL | |
| 25 mM | 0.2895 mL | 1.4476 mL | 2.8952 mL | 7.2380 mL | |
| 30 mM | 0.2413 mL | 1.2063 mL | 2.4127 mL | 6.0317 mL | |
| 40 mM | 0.1809 mL | 0.9047 mL | 1.8095 mL | 4.5237 mL | |
| 50 mM | 0.1448 mL | 0.7238 mL | 1.4476 mL | 3.6190 mL | |
| 60 mM | 0.1206 mL | 0.6032 mL | 1.2063 mL | 3.0158 mL | |
| 80 mM | 0.0905 mL | 0.4524 mL | 0.9047 mL | 2.2619 mL | |
| 100 mM | 0.0724 mL | 0.3619 mL | 0.7238 mL | 1.8095 mL |
2,3-Dimethylhydroquinone Related Classifications
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