Ethyl 3,4,5-trimethoxybenzoate
Based on 1 Customer Validation
Ethyl 3,4,5-trimethoxybenzoate is a melanogenesis inhibitor. Ethyl 3,4,5-trimethoxybenzoate does not directly target tyrosinase activity, but inhibits melanin synthesis in a dose-dependent manner by downregulating α-MSH (HY-P0252)-induced tyrosinase protein expression and scavenging ROS. Ethyl 3,4,5-trimethoxybenzoate scavenges DPPH free radicals. Ethyl 3,4,5-trimethoxybenzoate can be used in the research of hyperpigmentation.
For research use only. We do not sell to patients.
- Purity: 99.67%
- CAS No.: 6178-44-5
- Formula: C12H16O5
- Molecular Weight:240.25
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Ethyl 3,4,5-trimethoxybenzoate (2-100 μg/mL; 24-72 h) shows no cytotoxicity at concentrations up to 10 μg/mL, while it reduces cell viability to below 80% at concentrations ≥ 25 μg/mL[1].
Ethyl 3,4,5-trimethoxybenzoate (2-10 μg/mL) exerts no significant inhibitory effect on the catalytic activity of mushroom tyrosinase[1].
Ethyl 3,4,5-trimethoxybenzoate (10 μg/mL; 24 h) reduces α-MSH-stimulated extracellular melanin production in B16F10 melanoma cells to 88.4% of the control level at a concentration of 10 μg/mL[1].
Ethyl 3,4,5-trimethoxybenzoate (2-10 μg/mL; 72 h) reduces α-MSH-stimulated melanogenesis in B16F10 melanoma cells in a dose-dependent manner[1].
Ethyl 3,4,5-trimethoxybenzoate (2-10 μg/mL; 72 h) dose-dependently inhibits α-MSH-stimulated tyrosinase activity in B16F10 melanoma cells[1].
Ethyl 3,4,5-trimethoxybenzoate (10 μg/mL; 72 h) reduces the expression of tyrosinase protein in α-MSH-stimulated B16F10 melanoma cells[1].
Ethyl 3,4,5-trimethoxybenzoate (2-10 μg/mL; 80 min) scavenges DPPH free radicals in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:α-MSH-stimulated B16F10 melanoma cells
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Concentration:10 μg/mL
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Incubation Time:72 h
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Result:Considerably reduced α-MSH-induced tyrosinase protein expression in cells compared to the arbutin control.
Chemical Information
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CAS No. 6178-44-5
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Appearance Solid
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Molecular Weight 240.25
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Formula C12H16O5
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Color White to off-white
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SMILES
O=C(OCC)C1=CC(OC)=C(OC)C(OC)=C1
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (416.23 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (288 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1623 mL | 20.8117 mL | 41.6233 mL | 104.0583 mL |
| 5 mM | 0.8325 mL | 4.1623 mL | 8.3247 mL | 20.8117 mL | |
| 10 mM | 0.4162 mL | 2.0812 mL | 4.1623 mL | 10.4058 mL | |
| 15 mM | 0.2775 mL | 1.3874 mL | 2.7749 mL | 6.9372 mL | |
| 20 mM | 0.2081 mL | 1.0406 mL | 2.0812 mL | 5.2029 mL | |
| 25 mM | 0.1665 mL | 0.8325 mL | 1.6649 mL | 4.1623 mL | |
| 30 mM | 0.1387 mL | 0.6937 mL | 1.3874 mL | 3.4686 mL | |
| 40 mM | 0.1041 mL | 0.5203 mL | 1.0406 mL | 2.6015 mL | |
| 50 mM | 0.0832 mL | 0.4162 mL | 0.8325 mL | 2.0812 mL | |
| 60 mM | 0.0694 mL | 0.3469 mL | 0.6937 mL | 1.7343 mL | |
| 80 mM | 0.0520 mL | 0.2601 mL | 0.5203 mL | 1.3007 mL | |
| 100 mM | 0.0416 mL | 0.2081 mL | 0.4162 mL | 1.0406 mL |
Ethyl 3,4,5-trimethoxybenzoate Related Classifications
HY-W012092 Related Classifications
Powered by Bioz
- Ethyl 3,4,5-trimethoxybenzoate
- 6178-44-5
- Tyrosinase
- Reactive Oxygen Species (ROS)
- antioxidant
- tyrosinase activity
- intracellular melanin production
- tyrosinase protein expression
- DPPH free radicals
- α-MSH
- B16F10 melanoma cells
- extracellular melanin production
- hyperpigmentation
- melanin production inhibitor
- Inhibitor
- inhibitor
- inhibit