1. GPCR/G Protein
  2. Adrenergic Receptor
  3. Tulobuterol hydrochloride

Tulobuterol hydrochloride 

Cat. No.: HY-W011733 Purity: 99.82%
Handling Instructions

Tulobuterol hydrochloride is a β2-adrenoceptor agonist.

For research use only. We do not sell to patients.

Tulobuterol hydrochloride Chemical Structure

Tulobuterol hydrochloride Chemical Structure

CAS No. : 56776-01-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 80 In-stock
Estimated Time of Arrival: December 31
500 mg USD 130 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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  • References

Description

Tulobuterol hydrochloride is a β2-adrenoceptor agonist.

IC50 & Target

β2-adrenoceptor[1]

In Vitro

Treatment of the cells with Tulobuterol (0.1 μM) significantly decreases the viral titers of RV14 in the supernatants from 12 h after infection compared with the titers in the cells treated with vehicle (0.001% ethanol). Tulobuterol reduces RV14 release in a concentration-dependent manner. Pretreatment of the cells with Tulobuterol reduces the viral titers of RV14 in the supernatants at concentrations of 0.1 μM or greater[2].

In Vivo

Tulobuterol, a sympathomimetic drug used as a transdermal patch, increases normal diaphragm muscle strength. In vivo effect of Tulobuterol is examined the on the contractility of diaphragm muscles prepared from mice treated with Endotoxin. In the in vivo treatment, E0 and E4 diaphragm muscles are analyzed at 0, 12, and 24 h after transdermal Tulobuterol treatment. The force-frequency curves of E0 and E4 diaphragm muscles at three time points are not significantly changed each other, indicating that Tulobuterol patch restores the muscle contractility. Thus, diaphragm muscle contractility is maintained during 4 h of Endotoxin administration with Tulobuterol patch for over 24 h[3].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (189.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7852 mL 18.9258 mL 37.8515 mL
5 mM 0.7570 mL 3.7852 mL 7.5703 mL
10 mM 0.3785 mL 1.8926 mL 3.7852 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[2]

To examine the effects of Tulobuterol, cultured human tracheal epithelial cells from the same donors are treated with either Tulobuterol (0.1 μM) or the vehicle (0.001% ethanol) from 3 days (72 h) before RV14 infection until the end of the experiments after RV14 infection[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[3]

Mice[3]
Experiments are performed on 50 BALB/c mice weighing 21.7±0.2 g, which are divided into 2 groups. In the transdermal Tulobuterol treatment group, a small piece (4×4 mm2) of a 0.5 mg Tulobuterol patch sheet (16×16 mm2) is affxed to the shaved back of each animal and covered with a small adhesive strip. To examine the effect of transdermal Tulobuterol treatment, the diaphragm muscles of mice immediately after E.coli Endotoxin (20 mg/kg) administration are dissected and measured for contractility at 0, 12, and 24 h (n=5 each) after patch affxation, termed T0E0, T12E0, and T24E0, respectively; to examine such effect 4 h after E.coli Endotoxin (20 mg/kg) injection, the diaphragm muscles of another group of mice are dissected and measured for contractility at 0+4,12+4,and 24+4 h (n=5 each) after patch affxation,termed T0E4, T12E4, and T24E4, respectively.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

264.19

Formula

C₁₂H₁₉Cl₂NO

CAS No.

56776-01-3

SMILES

CC(C)(NCC(O)C1=CC=CC=C1Cl)C.Cl

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Tulobuterol hydrochloride
Cat. No.:
HY-W011733
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Tulobuterol hydrochloride

Cat. No.: HY-W011733