2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-107591
    (Rac)-PF-184 1187460-81-6 98%
    (Rac)-PF-184 is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC50 of 37 nM. (Rac)-PF-184 has anti-inflammatory effects.
    (Rac)-PF-184
  • HY-107592
    ACHP 406208-42-2 98%
    ACHP (compound 4j) is a selective and orally active IκB kinase inhibitor with IC50 values of 8.5 nM and 250 nM for IKKβ and IKKα, respectively. ACHP can effectively inhibit the STAT3 signaling pathway and induce cancer cell cycle arrest and apoptosis. ACHP shows anti-inflammatory activity in a mouse ear edema model. ACHP can be used in anti-inflammatory and anti-cancer (such as multiple myeloma and leukemia) studies.
    ACHP
  • HY-107611
    Ro 24-5913 128312-51-6 98%
    Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC50 value of 6.4 nM. Ro 24-5913 can be used for the research of asthma.
    Ro 24-5913
  • HY-107666
    PHA 568487 527680-57-5 98%
    PHA 568487 a selective agonist of alpha-7 nicotinic acetylcholine receptor (α-7 nAchR).PHA 568487 reduces neuroinflammation and oxidative stress. PHA-568487 has rapid brain penetration.
    PHA 568487
  • HY-107710
    LY 233053 125546-04-5 98%
    LY 233053 is a potent and competitive NMDA-receptor antagonist with anticonvulsant and antiepileptic efficacy.
    LY 233053
  • HY-107736
    AI-3 882288-28-0 98%
    AI-3 is a potent ARE (antioxidant response element) activator. AI-3 increases the NQO1 at the transcript levels and protein expression levels. AI-3 has the potential for the research of oxidative stress related diseases.
    AI-3
  • HY-107787
    Dioxopromethazine 13754-56-8 98%
    Dioxopromethazine is an orally active antihistamine. Dioxopromethazine inhibits asthmatic symptoms.
    Dioxopromethazine
  • HY-107796
    Metamizole magnesium 63372-86-1 98%
    Metamizole magnesium is an orally active cyclooxygenase (COX) inhibitor. Metamizole magnesium can inhibit cell proliferation and promote cell apoptosis. Metamizole magnesium has anti-inflammatory and antioxidant activities. Metamizole magnesium is an antipyretic, analgesic and spasmolytic agent.
    Metamizole magnesium
  • HY-107932
    Triamcinolone diacetate 67-78-7 98%
    Triamcinolone diacetate is a synthetic derivative of glucocorticoid. Triamcinolone diacetate has anti-inflammatory activity. Triamcinolone diacetate can be used in research on dermatomyositis, Bell's palsy and rheumatoid arthritis.
    Triamcinolone diacetate
  • HY-107965
    Safflower oil (from Carthamus tinctorius seed) 8001-23-8 98%
    Safflower oil (from Carthamus tinctorius seed) is rich in unsaturated fatty acids such as linoleic acid and oleic acid, as well as tocopherols and phenolic compounds, and exhibits antioxidant, anti-aging and blood lipid-regulating effects. Safflower oil (from Carthamus tinctorius seed) inhibits the activities of collagenase and elastase, and exerts antioxidant activity by scavenging free radicals. Linoleic acid in safflower oil (from Carthamus tinctorius seed) reduces blood cholesterol levels. Safflower oil (from Carthamus tinctorius seed) can be applied to research in fields such as skin aging, atherosclerosis, edible oil processing and industrial raw material development.
    Safflower oil (from Carthamus tinctorius seed)
  • HY-108019
    SD 8381 215123-80-1 98%
    SD 8381 is a potent and selective COX-2 inhibitor. SD 8381 shows IC50 values of 0.0098 μM for hCOX-2 and 0.69 μM for hCOX-1.
    SD 8381
  • HY-108030
    Bencycloquidium bromide 860804-18-8 98%
    Bencycloquidium bromide, a muscarinic M(3) receptor antagonist, is an anticholinergic compound that acts as an anticholinergic bronchodilator. Bencycloquidium bromide can be used in the study for rhinitis.
    Bencycloquidium bromide
  • HY-108040
    NCX-6560 803728-45-2 98%
    NCX-6560 is an orally active nitric oxide releasing derivative of atorvastatin that inhibits cholesterol biosynthesis and has anti-inflammatory and antithrombotic activity.
    NCX-6560
  • HY-108050
    4-Hydroxyoxyphenbutazone 55648-39-0 98%
    4-Hydroxyoxyphenbutazone kills both replicating and nonreplicating (NR) Mycobacterium tuberculosis (Mtb), including Mtb resistant to standard agents. 4-Hydroxyoxyphenbutazone is a potent inhibitor of cytokine production. 4-Hydroxyoxyphenbutazone is an immunosuppressive agent and has the potential for rheumatoid arthritis research.
    4-Hydroxyoxyphenbutazone
  • HY-108106
    Y-36912 213600-06-7 98%
    Y-36912 is an orally active, highly selective and affinity 5-HT4 receptor agonist (Ki = 1.5 nM). Y-36912 can accelerate gastric emptying and increase bowel frequency and stool weight. Y-36912 can be used for research on gastrointestinal conditions.
    Y-36912
  • HY-108109
    P-8977 135810-00-3 98%
    P-8977 is a potent dual CO/5-LO inhibitor (IC50 = 0.01 µM). P-8977 can also inhibit cyclooxygenase (CO) (IC50 = 0.53 µM) in 3T3 cells. P-8977 can inhibit ear edema. P-8977 can be used for research on inflammatory skin conditions.
    P-8977
  • HY-108127
    NAA-004 402934-69-4 98%
    NAA-004 (NM-004) is a novel azo compound formed by linking 5-aminosalicylic acid and 4-aminophenylacetic acid through an azo bond. NAA-004 has oral activity. NAA-004 can inhibit colon damage, intracavitary fluid accumulation, and MPO activity. NAA-004 can be used for research on colitis.
    NAA-004
  • HY-108132
    Ro 23-9358 153125-17-8 98%
    Ro 23-9358 is a potent secretory phospholipase A2 inhibitor with anti-inflammatory activity.
    Ro 23-9358
  • HY-108136
    Bisindolylmaleimide X 131848-97-0 98%
    Bisindolylmaleimide X (Ro 31-8425, BIM-X) is a cell-penetrating PKC inhibitor. Bisindolylmaleimide X is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC50 of 200 nM. Bisindolylmaleimide X inhibits the proliferation of CD4 T cells in vitro. Bisindolylmaleimide X inhibits eNOS-Ser1177 phosphorylation in human embryonic vein endothelial cells. Bisindolylmaleimide X can be used for research on the immune system and cardiovascular diseases.
    Bisindolylmaleimide X
  • HY-108139
    F-14258 194942-63-7 98%
    F-14258 is a 5-HT1B/1D receptor agonist. F-14258 can achieve receptor specific analgesia through local administration. F-14258 can be used for research on ear pain.
    F-14258
Cat. No. Product Name / Synonyms Application Reactivity