AI-3
AI-3 is a potent ARE (antioxidant response element) activator. AI-3 increases the NQO1 at the transcript levels and protein expression levels. AI-3 has the potential for the research of oxidative stress related diseases.
For research use only. We do not sell to patients.
- CAS No.: 882288-28-0
- Formula: C11H13ClO3S2
- Molecular Weight:292.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
ARE[1]
AI-3 (0.1, 0.3, 1, 3.2, 10, 32 μM; 12, 24 h) increases the NQO1 at the transcript levels and protein expression levels in a dose-dependent manner in IMR-32 cells[1].
AI-3 (10 μM; 2-24 h) induces GSH synthesis starting from 4 h up to 24 h[1].
AI-3 requires Nrf2 and PI3K for its bioactivities in IMR-32 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:IMR-32 cells
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Concentration:0.1, 0.3, 1, 3.2, 10, 32 µM
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Incubation Time:24 h
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Result:Induced NQO1 protein expression starting from 0.3 μM.
Chemical Information
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CAS No. 882288-28-0
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Molecular Weight 292.80
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Formula C11H13ClO3S2
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SMILES
O=C1C2=C(S(=O)(C)=O)SC(Cl)=C2CC(C)(C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AI-3 Related Classifications
HY-107736 Related Classifications
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