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Cat. No.: HY-107611

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Ro 24-5913

(Synonyms: Cinalukast)

Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC₅₀ value of 6.4 nM. Ro 24-5913 can be used for the research of asthma.

For research use only. We do not sell to patients.

CAS No.: 128312-51-6
Formula: C₂₃H₂₈N₂O₃S
Molecular Weight:412.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Ro 24-5913 Chemical Structure

CAS No.: 128312-51-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Ro 24-5913 (Cinalukast) is an orally active and potent LTD4 antagonist with an IC₅₀ value of 6.4 nM. Ro 24-5913 can be used for the research of asthma^[1].

IC₅₀ & Target

IC50: 6.4 nM (LTD4)^[1]

All Leukotriene Receptor Isoforms :

In Vitro

Ro 24-5913 competes with [³H]LTD4 for its binding site in guinea pig lung membranes with an IC₅₀ value of 6.4 nM^[1].
Ro 24-5913 shows effective antagonist efficacy to LTD4-induced contractions with a pK_B value of 9.3^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ro 24-5913 (10 mg/kg i.v. and 100 mg/kg p.o.; once) inhibits LTD4-induced bronchoconstriction in guinea pigs with LD₅₀s of 0.13 and 0.12 mg/kg for i.v. and p.o. respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Guinea pigs^[1]
Dosage:

10 mg/kg
Administration:

Oral gavage; 10 mg/kg once
Result:

Inhibited LTD4-induced bronchoconstnction and antigen-induced bronchoconstnction in guinea pigs.

Chemical Information

CAS No. 128312-51-6
Molecular Weight 412.55
Formula C₂₃H₂₈N₂O₃S
SMILES

OC(C(CC)(CC)CC(NC1=CC=CC(/C=C/C2=NC(C3CCC3)=CS2)=C1)=O)=O
Synonyms

Cinalukast
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. O'Donnell M. Ro 24-5913: a potent, specific, orally active LTD4 antagonist. Ann N Y Acad Sci. 1991;629:413-5. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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