4-Hydroxyoxyphenbutazone
4-Hydroxyoxyphenbutazone kills both replicating and nonreplicating (NR) Mycobacterium tuberculosis (Mtb), including Mtb resistant to standard agents. 4-Hydroxyoxyphenbutazone is a potent inhibitor of cytokine production. 4-Hydroxyoxyphenbutazone is an immunosuppressive agent and has the potential for rheumatoid arthritis research.
For research use only. We do not sell to patients.
- CAS No.: 55648-39-0
- Formula: C19H20N2O4
- Molecular Weight:340.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
4-Hydroxyoxyphenbutazone kills R Mtb in liquid culture with an MIC of 100 μM in the presence of 0.5% BSA and an MIC of 25 μM at lower BSA concentrations. The bactericidal spectrum of 4-Hydroxyoxyphenbutazone is remarkably narrow, with weak activity against Mycobacterium smegmatis (MIC of 200 μM in 7H9 lacking BSA). 4-Hydroxyoxyphenbutazone was inactive on E. coli, S. enterica var[1].
4-Hydroxyoxyphenbutazone efficiently inhibits both monokines and Th1 and Th2 lymphokines in peripheral mononuclear cells (PBMC)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 55648-39-0
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Molecular Weight 340.37
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Formula C19H20N2O4
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SMILES
O=C1N(N(C(C1(CCCC)O)=O)C2=CC=C(C=C2)O)C3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ben Gold, et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. [Content Brief]
[2]. Anja Ten Brinke, et al. 4-Hydroxy-oxyphenbutazone is a potent inhibitor of cytokine production. Eur Cytokine Netw. 2005 Jun;16(2):144-51. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-Hydroxyoxyphenbutazone Related Classifications
HY-108050 Related Classifications
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