Triamcinolone diacetate
Based on 1 Customer Validation
Triamcinolone diacetate is a synthetic derivative of glucocorticoid. Triamcinolone diacetate has anti-inflammatory activity. Triamcinolone diacetate can be used in research on dermatomyositis, Bell's palsy and rheumatoid arthritis.
For research use only. We do not sell to patients.
- CAS No.: 67-78-7
- Formula: C25H31FO8
- Molecular Weight:478.51
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 67-78-7
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Appearance Powder
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Molecular Weight 478.51
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Formula C25H31FO8
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SMILES
C[C@@]12[C@](C[C@H]([C@]2(O)C(COC(C)=O)=O)OC(C)=O)([H])[C@@]3([H])[C@]([C@H](C1)O)([C@@]4(C(CC3)=CC(C=C4)=O)C)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (208.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.22 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References
[1]. KIRSCHBAUM JO. Dermatomyositis: treated with triamcinolone diacetate. Conn Med. 1959 Feb;23(2):69-72. [Content Brief]
[2]. PAULSON G, SATRAN R. Treatment of Bell's palsy with triamcinolone diacetate. Dis Nerv Syst. 1963 Apr;24:237-40. [Content Brief]
[3]. Zuckner J. Treatment of Rheumatoid Arthritis by Intramuscular Triamcinolone Acetonide and Triamcinolone Diacetate. Ann Rheum Dis. 1961 Sep;20(3):274-80. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.0898 mL | 10.4491 mL | 20.8982 mL | 52.2455 mL |
| 5 mM | 0.4180 mL | 2.0898 mL | 4.1796 mL | 10.4491 mL | |
| 10 mM | 0.2090 mL | 1.0449 mL | 2.0898 mL | 5.2246 mL | |
| 15 mM | 0.1393 mL | 0.6966 mL | 1.3932 mL | 3.4830 mL | |
| 20 mM | 0.1045 mL | 0.5225 mL | 1.0449 mL | 2.6123 mL | |
| 25 mM | 0.0836 mL | 0.4180 mL | 0.8359 mL | 2.0898 mL | |
| 30 mM | 0.0697 mL | 0.3483 mL | 0.6966 mL | 1.7415 mL | |
| 40 mM | 0.0522 mL | 0.2612 mL | 0.5225 mL | 1.3061 mL | |
| 50 mM | 0.0418 mL | 0.2090 mL | 0.4180 mL | 1.0449 mL | |
| 60 mM | 0.0348 mL | 0.1742 mL | 0.3483 mL | 0.8708 mL | |
| 80 mM | 0.0261 mL | 0.1306 mL | 0.2612 mL | 0.6531 mL | |
| 100 mM | 0.0209 mL | 0.1045 mL | 0.2090 mL | 0.5225 mL |
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