2. Cell Cycle/DNA Damage Apoptosis
  3. Nucleoside Antimetabolite/Analog Thymidylate Synthase
  4. Trifluridine/tipiracil hydrochloride mixture

Trifluridine/tipiracil hydrochloride mixture  (Synonyms: TAS-102; FTD/TPI)

Art. -Nr.: HY-16478 Reinheit: 99.96%
COA
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Handling Instructions Technical Support

Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA.

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CAS. Nr. : 733030-01-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Based on 3 publication(s) in Google Scholar

Other Forms of Trifluridine/tipiracil hydrochloride mixture:

Trifluridine/tipiracil hydrochloride mixture Related Antibodies

Top Publications Citing Use of Products
Cell Proliferation/Viability Assay
In Vivo Efficacy Study

    Trifluridine/tipiracil hydrochloride mixture purchased from MedChemExpress. Usage Cited in: Transl Oncol. 2025 Nov:61:102537.  [Abstract]

    Cell viability of UMUC3 cells treated with Trifluridine/tipiracil hydrochloride mixture (TAS-102, 20 μM) or DMSO.

    Trifluridine/tipiracil hydrochloride mixture purchased from MedChemExpress. Usage Cited in: Transl Oncol. 2025 Nov:61:102537.  [Abstract]

    In vivo tumor growth in C57BL/6 mice bearing MB49 xenografts treated with PBS, cisplatin, Trifluridine/tipiracil hydrochloride mixture (TAS-102, 20 mg/kg, ip, twice a week), or both (C + T); representative tumor images are shown.

    Trifluridine/tipiracil hydrochloride mixture purchased from MedChemExpress. Usage Cited in: Transl Oncol. 2025 Nov:61:102537.  [Abstract]

    In vivo tumor growth in C57BL/6 mice bearing MB49 xenografts treated with PBS, cisplatin, Trifluridine/tipiracil hydrochloride mixture (TAS-102, 20 mg/kg, ip, twice a week), or both (C + T); representative tumor weight are shown.

    Trifluridine/tipiracil hydrochloride mixture purchased from MedChemExpress. Usage Cited in: Transl Oncol. 2025 Nov:61:102537.  [Abstract]

    In vivo tumor growth in C57BL/6 mice bearing MB49 xenografts treated with PBS, cisplatin, Trifluridine/tipiracil hydrochloride mixture (TAS-102, 20 mg/kg, ip, twice a week), or both (C + T); representative tumor volume are shown.

    • Biologische Aktivität

    • Reinheit & Dokumentation

    • Verweise

    • Kundenbewertung

    Beschreibung

    Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA[1][2].

    In Vivo

    Trifluridine/tipiracil hydrochloride mixture (150 mg/kg/day; p.o.; twice a day for 14 days) prevents body weight loss and reduces the relative tumor volume in colorectal cancer and gastric cancer mice models[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male nude mice bearing KM12C, KM12C/5-FU, DLD-1, DLD-1/5-FU, and SC-2 cells[2]
    Dosage: 150 mg/kg/day
    Administration: p.o.; twice a day for 14 days
    Result: Prevented body weight loss and reduced the relative tumor volume in colorectal cancer and gastric cancer mice models.
    Klinische Studie
    Molekulargewicht

    435.76

    Formel

    C10H11F3N2O5.1/2C9H11ClN4O2.1/2HCl
    CAS. Nr.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C1N([C@H]2C[C@H](O)[C@@H](CO)O2)C=C(C(F)(F)F)C(N1)=O.O=C3NC(CN4CCCC4=N)=C(Cl)C(N3)=O.[1/2].Cl
    Versand

    Room temperature in continental US; may vary elsewhere.
    Speicherung

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Lösungsmittel & Löslichkeit
    In Vitro: 

    H2O : 100 mg/mL (229.48 mM; Need ultrasonic)

    DMSO : 50 mg/mL (114.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    DMF : 20 mg/mL (45.90 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2948 mL 11.4742 mL 22.9484 mL
    5 mM 0.4590 mL 2.2948 mL 4.5897 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molaritätsrechner

    • Verdünnungsrechner

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 50 mg/mL (114.74 mM); Clear solution; Need ultrasonic

    • Protocol 2

      Add each solvent one by one:  Saline

      Solubility: 100 mg/mL (229.48 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Reinheit & Dokumentation

    Purity: 99.96%

    SDS (394 KB)

    COA (249 KB) HNMR (145 KB) RP-HPLC (168 KB)

    Handling Instructions (2659 KB)
    Verweise

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMF / DMSO / H2O 1 mM 2.2948 mL 11.4742 mL 22.9484 mL 57.3710 mL
    5 mM 0.4590 mL 2.2948 mL 4.5897 mL 11.4742 mL
    10 mM 0.2295 mL 1.1474 mL 2.2948 mL 5.7371 mL
    15 mM 0.1530 mL 0.7649 mL 1.5299 mL 3.8247 mL
    20 mM 0.1147 mL 0.5737 mL 1.1474 mL 2.8686 mL
    25 mM 0.0918 mL 0.4590 mL 0.9179 mL 2.2948 mL
    30 mM 0.0765 mL 0.3825 mL 0.7649 mL 1.9124 mL
    40 mM 0.0574 mL 0.2869 mL 0.5737 mL 1.4343 mL
    DMSO / H2O 50 mM 0.0459 mL 0.2295 mL 0.4590 mL 1.1474 mL
    60 mM 0.0382 mL 0.1912 mL 0.3825 mL 0.9562 mL
    80 mM 0.0287 mL 0.1434 mL 0.2869 mL 0.7171 mL
    100 mM 0.0229 mL 0.1147 mL 0.2295 mL 0.5737 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Trifluridine/tipiracil hydrochloride mixture Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Trifluridine/tipiracil hydrochloride mixture733030-01-8TAS-102 FTD/TPITAS102TAS 102Nucleoside Antimetabolite/AnalogThymidylate SynthaseoralnucleosideantitumorFTDTPIthymidylate synthaseDNAInhibitorinhibitorinhibit

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