Trifluridine/tipiracil hydrochloride mixture (Synonyms: TAS-102; FTD/TPI)

Name: Trifluridine/tipiracil hydrochloride mixture
Brand: MedChemExpress
SKU: HY-16478
Rating: 5.0 (3 reviews)

Cat. No.: HY-16478 Purity: 99.96%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No. : 733030-01-8

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 3 publication(s) in Google Scholar

Other Forms of Trifluridine/tipiracil hydrochloride mixture:

Trifluridine In-stock
Tipiracil hydrochloride In-stock
Tipiracil In-stock

3 Publications Citing Use of MCE Trifluridine/tipiracil hydrochloride mixture

Cell Proliferation/Viability Assay

In Vivo Efficacy Study

: Trifluridine/tipiracil hydrochloride mixture purchased from MedChemExpress. Usage Cited in: Transl Oncol. 2025 Nov:61:102537. [Abstract]; Cell viability of UMUC3 cells treated with Trifluridine/tipiracil hydrochloride mixture (TAS-102, 20 μM) or DMSO.

: Trifluridine/tipiracil hydrochloride mixture purchased from MedChemExpress. Usage Cited in: Transl Oncol. 2025 Nov:61:102537. [Abstract]; In vivo tumor growth in C57BL/6 mice bearing MB49 xenografts treated with PBS, cisplatin, Trifluridine/tipiracil hydrochloride mixture (TAS-102, 20 mg/kg, ip, twice a week), or both (C + T); representative tumor images are shown.

: Trifluridine/tipiracil hydrochloride mixture purchased from MedChemExpress. Usage Cited in: Transl Oncol. 2025 Nov:61:102537. [Abstract]; In vivo tumor growth in C57BL/6 mice bearing MB49 xenografts treated with PBS, cisplatin, Trifluridine/tipiracil hydrochloride mixture (TAS-102, 20 mg/kg, ip, twice a week), or both (C + T); representative tumor weight are shown.

: Trifluridine/tipiracil hydrochloride mixture purchased from MedChemExpress. Usage Cited in: Transl Oncol. 2025 Nov:61:102537. [Abstract]; In vivo tumor growth in C57BL/6 mice bearing MB49 xenografts treated with PBS, cisplatin, Trifluridine/tipiracil hydrochloride mixture (TAS-102, 20 mg/kg, ip, twice a week), or both (C + T); representative tumor volume are shown.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vivo

Trifluridine/tipiracil hydrochloride mixture (150 mg/kg/day; p.o.; twice a day for 14 days) prevents body weight loss and reduces the relative tumor volume in colorectal cancer and gastric cancer mice models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male nude mice bearing KM12C, KM12C/5-FU, DLD-1, DLD-1/5-FU, and SC-2 cells^[2]
Dosage:	150 mg/kg/day
Administration:	p.o.; twice a day for 14 days
Result:	Prevented body weight loss and reduced the relative tumor volume in colorectal cancer and gastric cancer mice models.

Clinical Trial

분자량

435.76

화학식

C₁₀H₁₁F₃N₂O₅.1/2C₉H₁₁ClN₄O₂.1/2HCl

CAS No.

733030-01-8

Appearance

Solid

Color

White to off-white

SMILES

O=C1N([C@H]2C[C@H](O)[C@@H](CO)O2)C=C(C(F)(F)F)C(N1)=O.O=C3NC(CN4CCCC4=N)=C(Cl)C(N3)=O.[1/2].Cl

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

H₂O : 100 mg/mL (229.48 mM; Need ultrasonic)

DMSO : 50 mg/mL (114.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : 20 mg/mL (45.90 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2948 mL	11.4742 mL	22.9484 mL
5 mM	0.4590 mL	2.2948 mL	4.5897 mL
10 mM	0.2295 mL	1.1474 mL	2.2948 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (114.74 mM); Clear solution; Need ultrasonic
Protocol 2

Add each solvent one by one: Saline
Solubility: 100 mg/mL (229.48 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.96%

Select Batch:

Data Sheet (274 KB) SDS (394 KB)

COA (249 KB) HNMR (145 KB) RP-HPLC (168 KB)

Handling Instructions (2659 KB)

References

[1]. Emura T, et al. A novel antimetabolite, TAS-102 retains its effect on FU-related resistant cancer cells. Int J Mol Med. 2004;13(4):545-549. [Content Brief]

[2]. Nukatsuka M, et al. Efficacy of combination chemotherapy using a novel oral chemotherapeutic agent, TAS-102, with irinotecan hydrochloride on human colorectal and gastric cancer xenografts. Anticancer Res. 2015;35(3):1437-1445. [Content Brief]

[3]. Limagne E, Thibaudin M, Nuttin L, et al. Trifluridine/Tipiracil plus Oxaliplatin Improves PD-1 Blockade in Colorectal Cancer by Inducing Immunogenic Cell Death and Depleting Macrophages. Cancer Immunol Res. 2019;7(12):1958-1969. [Content Brief]

[4]. Suzuki N, Nakagawa F, Takechi T. Trifluridine/tipiracil increases survival rates in peritoneal dissemination mouse models of human colorectal and gastric cancer [published correction appears in Oncol Lett. 2021 Jul;22(1):511]. Oncol Lett. 2017;14(1):639-646. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF / DMSO / H₂O	1 mM	2.2948 mL	11.4742 mL	22.9484 mL	57.3710 mL
	5 mM	0.4590 mL	2.2948 mL	4.5897 mL	11.4742 mL
	10 mM	0.2295 mL	1.1474 mL	2.2948 mL	5.7371 mL
	15 mM	0.1530 mL	0.7649 mL	1.5299 mL	3.8247 mL
	20 mM	0.1147 mL	0.5737 mL	1.1474 mL	2.8686 mL
	25 mM	0.0918 mL	0.4590 mL	0.9179 mL	2.2948 mL
	30 mM	0.0765 mL	0.3825 mL	0.7649 mL	1.9124 mL
	40 mM	0.0574 mL	0.2869 mL	0.5737 mL	1.4343 mL
DMSO / H₂O	50 mM	0.0459 mL	0.2295 mL	0.4590 mL	1.1474 mL
	60 mM	0.0382 mL	0.1912 mL	0.3825 mL	0.9562 mL
	80 mM	0.0287 mL	0.1434 mL	0.2869 mL	0.7171 mL
	100 mM	0.0229 mL	0.1147 mL	0.2295 mL	0.5737 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Trifluridine/tipiracil hydrochloride mixture Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trifluridine/tipiracil hydrochloride mixture733030-01-8TAS-102 FTD/TPITAS102TAS 102Nucleoside Antimetabolite/AnalogThymidylate SynthaseoralnucleosideantitumorFTDTPIthymidylate synthaseDNAInhibitorinhibitorinhibit

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Trifluridine/tipiracil hydrochloride mixture (Synonyms: TAS-102; FTD/TPI)

고객리뷰

Other Forms of Trifluridine/tipiracil hydrochloride mixture:

Trifluridine/tipiracil hydrochloride mixture Related Antibodies

3 Publications Citing Use of MCE Trifluridine/tipiracil hydrochloride mixture

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Trifluridine/tipiracil hydrochloride mixture Related Classifications

Keywords:

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고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report