Beta-secretase

Beta-secretase Related Products (82):

By Effects:	Inhibitors (71) Control (1)

Cat. No.	Product Name	Effect	Purity

HY-119689

Umibecestat	Inhibitor	99.81%
Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC₅₀s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of alzheimer's disease.

HY-10133

β-Secretase Inhibitor IV	Inhibitor	99.19%
β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC₅₀s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.

HY-13769A

TPT-260 Dihydrochloride		98.0%
TPT-260 Dihydrochloride (NSC55712), a thiophene thiourea derivative, is a retromer complex stabilizer against thermal denaturation (K_d = ~5 µM). TPT-260 Dihydrochloride increases the levels of retromer proteins, shifts amyloid-precursor protein (APP) away from the endosome, and decreases the pathogenic processing of APP. TPT-260 Dihydrochloride inhibits TLR4 upregulation, IKKβ phosphorylation, NF-κB p65 nuclear translocation, and NLRP3 inflammasome formation. TPT-260 Dihydrochloride improves retromer-mediated cargo trafficking, reduces brain infarct area, and decreases amyloid plaque deposition. TPT-260 Dihydrochloride exhibits minimal cytotoxicity to primary microglia at tested concentrations. TPT-260 Dihydrochloride can be used for the research of inflammatory bowel disease, ischemic stroke and Alzheimer's disease.

HY-B0703

Eslicarbazepine acetate	Inhibitor	99.92%
Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.

HY-114703

Eslicarbazepine	Inhibitor	99.94%
Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures.

HY-125405

AZ3971	Inhibitor
AZ3971 is an orally active, blood-brain barrier permeable BACE1 inhibitor that does not affect the activity of γ-secretase. AZ3971 reduces the production of Aβ. AZ3971 can be used for the research of Alzheimer's disease.

HY-165226

β-Secretase-IN-5	Inhibitor
β-Secretase-IN-5 is a Beta-secretase inhibitor. β-Secretase-IN-5 reduces the production of Aβ_1-40 and Aβ_1-42. β-Secretase-IN-5 is applicable to research related to Alzheimer's disease.

HY-N0495

Aloenin	Inhibitor	99.91%
Aloenin (Aloenin A) is a kind of natural product, has effective clearing and free radical activity, and has moderate inhibitory activity on β-secretion (BACE) (IC50=14.95 μg/mL). Aloenin suppresses peritoneal hypertrophy in large rats and suppresses its release.

HY-RS01333

BACE1 Human Pre-designed siRNA Set A	Inhibitor
BACE1 Human Pre-designed siRNA Set A contains three designed siRNAs for BACE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-108966

Kushenol C	Inhibitor	99.58%
Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC₅₀ of 5.45 µM.

HY-N7887

Cassiaside	Inhibitor	99.67%
Cassiaside is a naphthopyrone glucoside, shows mixed-type inhibition against BACE1 (IC₅₀=4.45 μM; K_i=9.85 μM). Cassiaside possesses potential anti- Alzheimer's disease (AD) activity.

HY-P1962

β-Secretase inhibitor	Inhibitor	98.06%
β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) is a β-secretase and BACE1 inhibitor (IC₅₀: 25 nM for β-secretase).

HY-114245R

Se-Methylselenocysteine (Standard)	Inhibitor
Risedronic acid (Standard) is the analytical standard of Risedronic acid. This product is intended for research and analytical applications. 0

HY-16759A

Verubecestat TFA	Inhibitor	98.32%
Verubecestat (MK-8931) TFA is an orally active, high-affinity BACE1 and BACE2 inhibitor with K_i values of 2.2 nM and 0.38 nM. Verubecestat TFA effectively reduces Aβ40 and has the potential for Alzheimer's Disease.

HY-W015515R

L-Citronellol (Standard)	Inhibitor
L-Citronellol ((S)-3,7-Dimethyloct-6-en-1-ol) is an analytical standard for L-Citronellol (HY-W015515). This product is intended for research and analytical applications. L-Citronellol is a natural product with anti-allergic and neuroprotective effects. L-Citronellol inhibits mast cell activation and the release of inflammatory factors by inhibiting the ERK pathway. L-Citronellol inhibits BACE1/PSEN1 and AChE, reduces TNF-α expression and lipid peroxidation, demonstrating the potential of multi-target anti-Alzheimer's disease (AD).

HY-N8890

Demissidine	Inhibitor
Demissidine is an alkaloid that can be isolated from potato. Demissidine is a promising dual inhibitors against β- and γ-secretase proteins in silico.

HY-131068

BACE-1 inhibitor 2	Inhibitor
BACE-1 inhibitor 2 is a potent and CNS permeable BACE-1 inhibitor with an IC₅₀ of 1.5 nM in BACE-1 enzymatic assay.

HY-13240A

LY2886721 hydrochloride	Inhibitor
LY2886721 hydrochloride is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC₅₀ of 20.3 nM for recombinant human BACE1. LY2886721 hydrochloride is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC₅₀ of 10.2 nM). LY2886721 hydrochloride can across blood-brain barrier and has the potential for Alzheimer's disease treatment.

HY-118098

LY3202626	Inhibitor
LY3202626 is a CNS penetrant BACE inhibitor with IC₅₀s of 0.615 nM and 0.871 nM against BACE1 and BACE2, respectively.

HY-112297

BACE-1 inhibitor 1	Inhibitor
BACE-1 inhibitor 1 (Compound 8a) is a potent BACE-1 inhibitor with an IC₅₀ of 56 nM.

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