Beta-secretase
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Beta-secretase Related Products (82)
Related Products (82)
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Umibecestat
0 ImagesSynonyms: CNP520Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of alzheimer's disease.
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TPT-260 Dihydrochloride
0 ImagesTPT-260 Dihydrochloride (NSC55712), a thiophene thiourea derivative, is a retromer complex stabilizer against thermal denaturation (Kd = ~5 µM). TPT-260 Dihydrochloride increases the levels of retromer proteins, shifts amyloid-precursor protein (APP) away from the endosome, and decreases the pathogenic processing of APP. TPT-260 Dihydrochloride inhibits TLR4 upregulation, IKKβ phosphorylation, NF-κB p65 nuclear translocation, and NLRP3 inflammasome formation. TPT-260 Dihydrochloride improves retromer-mediated cargo trafficking, reduces brain infarct area, and decreases amyloid plaque deposition. TPT-260 Dihydrochloride exhibits minimal cytotoxicity to primary microglia at tested concentrations. TPT-260 Dihydrochloride can be used for the research of inflammatory bowel disease, ischemic stroke and Alzheimer's disease.
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β-Secretase Inhibitor IV
0 Imagesβ-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.
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Eslicarbazepine acetate
0 ImagesSynonyms: BIA 2-093Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel.
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Eslicarbazepine
0 ImagesSynonyms: BIA 2-194Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures.
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SIB-1281
0 ImagesCat. No.: HY-187132CAS No.: 181139-85-5SIB-1281 is a β-secretase inhibitor that inhibits β-site cleavage of amyloid precursor protein (APP) and reduces the production of Aβ peptides. SIB-1281 decreases the generation of Aβ40 and Aβ42, and promotes the secretion of α-sAPP. SIB-1281 can be used in studies related to Alzheimer's disease.
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AZ3971
0 ImagesCat. No.: HY-125405CAS No.: 1260248-03-0AZ3971 is an orally active, blood-brain barrier permeable BACE1 inhibitor that does not affect the activity of γ-secretase. AZ3971 reduces the production of Aβ. AZ3971 can be used for the research of Alzheimer's disease.
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β-Secretase-IN-5
0 Imagesβ-Secretase-IN-5 is a Beta-secretase inhibitor. β-Secretase-IN-5 reduces the production of Aβ1-40 and Aβ1-42. β-Secretase-IN-5 is applicable to research related to Alzheimer's disease.
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Aloenin
0 ImagesSynonyms: Aloenin AAloenin (Aloenin A) is a kind of natural product, has effective clearing and free radical activity, and has moderate inhibitory activity on β-secretion (BACE) (IC50=14.95 μg/mL). Aloenin suppresses peritoneal hypertrophy in large rats and suppresses its release.
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L-Citronellol (Standard)
0 ImagesSynonyms: (S)-3,7-Dimethyloct-6-en-1-ol (Standard)L-Citronellol ((S)-3,7-Dimethyloct-6-en-1-ol) is an analytical standard for L-Citronellol (HY-W015515). This product is intended for research and analytical applications. L-Citronellol is a natural product with anti-allergic and neuroprotective effects. L-Citronellol inhibits mast cell activation and the release of inflammatory factors by inhibiting the ERK pathway. L-Citronellol inhibits BACE1/PSEN1 and AChE, reduces TNF-α expression and lipid peroxidation, demonstrating the potential of multi-target anti-Alzheimer's disease (AD).
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Se-Methylselenocysteine (Standard)
0 ImagesSynonyms: Methylselenocysteine (Standard); Se-Methylseleno-L-cysteine (Standard)Risedronic acid (Standard) is the analytical standard of Risedronic acid. This product is intended for research and analytical applications. 0
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Verubecestat TFA
0 ImagesSynonyms: MK-8931 TFA
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Demissidine
0 ImagesDemissidine is an alkaloid that can be isolated from potato. Demissidine is a promising dual inhibitors against β- and γ-secretase proteins in silico.
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BACE-1 inhibitor 2
0 ImagesCat. No.: HY-131068CAS No.: 2563970-92-1BACE-1 inhibitor 2 is a potent and CNS permeable BACE-1 inhibitor with an IC50 of 1.5 nM in BACE-1 enzymatic assay.
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LY2886721 hydrochloride
0 ImagesCat. No.: HY-13240ACAS No.: 1262036-49-6LY2886721 hydrochloride is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 hydrochloride is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM). LY2886721 hydrochloride can across blood-brain barrier and has the potential for Alzheimer's disease treatment.
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LY3202626
0 ImagesCat. No.: HY-118098CAS No.: 1628690-73-2
