LY3202626
LY3202626 is a CNS penetrant BACE inhibitor with IC50s of 0.615 nM and 0.871 nM against BACE1 and BACE2, respectively.
For research use only. We do not sell to patients.
- CAS No.: 1628690-73-2
- Formula: C22H20F2N8O2S
- Molecular Weight:498.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.615 nM (BACE1), 0.871 nM (BACE2)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.615 nM
Compound: 7; LY-3202626
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Inhibition of human BACE1 (1 to 460 residues) expressed in HEK293 cells after 16 to 24 hrs by FRET assay
Inhibition of human BACE1 (1 to 460 residues) expressed in HEK293 cells after 16 to 24 hrs by FRET assay
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[PMID: 30709653] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1628690-73-2
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Molecular Weight 498.51
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Formula C22H20F2N8O2S
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SMILES
O=C(NC1=CC=C(C([C@@]23N=C(SC[C@@]2(CN(C3)C4=NC=C(C=N4)F)[H])N)=C1)F)C5=NC=C(N=C5)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LY3202626 Related Classifications
HY-118098 Related Classifications
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