2. Neuronal Signaling
  3. Beta-secretase
  4. LY3202626

LY3202626 is a CNS penetrant BACE inhibitor with IC50s of 0.615 nM and 0.871 nM against BACE1 and BACE2, respectively.

For research use only. We do not sell to patients.

LY3202626 Chemical Structure

LY3202626 Chemical Structure

CAS No. : 1628690-73-2

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Description

LY3202626 is a CNS penetrant BACE inhibitor with IC50s of 0.615 nM and 0.871 nM against BACE1 and BACE2, respectively[1].

IC50 & Target

IC50: 0.615 nM (BACE1), 0.871 nM (BACE2)[1]
Molecular Weight

498.51

Formula

C22H20F2N8O2S
CAS No.
SMILES

O=C(NC1=CC=C(C([C@@]23N=C(SC[C@@]2(CN(C3)C4=NC=C(C=N4)F)[H])N)=C1)F)C5=NC=C(N=C5)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LY3202626 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY32026261628690-73-2LY 3202626LY-3202626Beta-secretaseBACEβ-SecretaseCNS penetrantliver injuryInhibitorinhibitorinhibit

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