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Cat. No.: HY-131068

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BACE-1 inhibitor 2

BACE-1 inhibitor 2 is a potent and CNS permeable BACE-1 inhibitor with an IC₅₀ of 1.5 nM in BACE-1 enzymatic assay.

For research use only. We do not sell to patients.

CAS No.: 2563970-92-1
Formula: C₂₁H₂₁F₄N₅O₃
Molecular Weight:467.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

BACE-1 inhibitor 2 Chemical Structure

CAS No.: 2563970-92-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

BACE-1 inhibitor 2 is a potent and CNS permeable BACE-1 inhibitor with an IC₅₀ of 1.5 nM in BACE-1 enzymatic assay^[1].

IC₅₀ & Target

IC50: 1.5 nM (BACE-1)^[1]

All Beta-secretase Isoforms :

BACE1
BACE2

In Vitro

BACE-1 inhibitor 2 inhibits Aβ42 production in human neuroblastoma cell lines with an IC₅₀ of 3.5 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2563970-92-1
Molecular Weight 467.42
Formula C₂₁H₂₁F₄N₅O₃
SMILES

[H][C@]12CC(F)(C(N)=N[C@@]1(C3=C(C=CC(NC(C4=NC=C(N=C4)OCF)=O)=C3)F)CO[C@@H](C)C2)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Aldo Peschiulli , et al. 3,3-Difluoro-3,4,5,6-tetrahydropyridin-2-amines: Potent and Permeable BACE-1 Inhibitors. Bioorg Med Chem Lett. 2020 Apr 15;30(8):126999. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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BACE-1 inhibitor 2

All Beta-secretase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

BACE-1 inhibitor 2 Related Classifications

HY-131068 Related Classifications