CK2 Inhibitor

CK2 Inhibitors (38):

Cat. No.	Product Name	Effect	Purity

HY-50855

Silmitasertib	Inhibitor	99.94%
Silmitasertib (CX-4945) is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC₅₀ values of 1 nM against CK2α and CK2α'.

HY-14393

Emodin	Inhibitor	99.25%
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects. Emodin is a potent selective 11β-HSD1 inhibitor with the IC₅₀ of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice.

HY-B0183

Ellagic acid	Inhibitor	99.46%
Ellagic acid is a natural antioxidant, and acts as a potent and ATP-competitive inhibitor of CK2 and SHP2, with an IC₅₀ of 40 nM and a K_i of 20 nM.

HY-14394

TBB	Inhibitor	98.83%
TBB is a cell-permeable and ATP-competitive CK2 inhibitor with an IC₅₀ of 0.15 μM for rat liver CK2.

HY-50855B

Silmitasertib sodium salt	Inhibitor	99.92%
Silmitasertib sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC₅₀ values of 1 nM against CK2α and CK2α'.

HY-169985

CK2-IN-13	Inhibitor
CK2-IN-13 (compound 12c) is a potent inhibitor of CK2, with the IC₅₀ of 5.8 nM. CK2-IN-13 plays an important role in cancer research.

HY-168517

PIM-1/CK2-IN-2	Inhibitor
PIM-1/CK2-IN-2 (compound 3aA) is a PIM-1/CK2 inhibitor. PIM-1/CK2-IN-2 can induce the mitochondrial apoptotic pathway in CCRF-CEM cells. PIM-1/CK2-IN-2 can be used in cancer research.

HY-169629

CK2 inhibitor 4	Inhibitor
CK2 inhibitor 4 (compound 5b) is a protein kinase CK2 inhibitor with IC₅₀ of 3.8 μM. CK2 inhibitor 4 can be used in tumor research.

HY-15535

DMAT	Inhibitor	98.09%
DMAT is a potent and specific CK2 inhibitor with an IC₅₀ value of 130 nM.

HY-139004

SGC-CK2-1	Inhibitor	99.67%
SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC₅₀s of 36 and 16 nM for CK2α and CK2α′respectively in the nanoBRET assay. SGC-CK2-1 can be used for the research of neurodegenerative diseases.

HY-10108A

LY294002 hydrochloride	Inhibitor	99.93%
LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC₅₀ values of 0.5, 0.57, and 0.97 μM for P110α, P110δ and P110β, respectively. LY294002 hydrochloride also inhibits CK2 with an IC₅₀ of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research.

HY-129571

BioE-1115	Inhibitor	99.56%
BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC₅₀ of ~4 nM. BioE-1115 is also a potent casein kinase 2α inhibitor with an IC₅₀ of ~10 μM.

HY-135906

CK2/ERK8-IN-1	Inhibitor	≥99.0%
CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (K_i of 0.25 µM) and ERK8 (MAPK15, ERK7) inhibitor with IC₅₀s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with K_is of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy.

HY-15479

TTP 22	Inhibitor	98.40%
TTP 22 is a potent CK2 inhibitor, with an IC₅₀ of 100 nM and a K_i of 40 nM.

HY-119751

Hematein	Inhibitor
Hematein is a oxidation product of hematoxylin acted as a dye. Hematein is an allosteric casein kinase II inhibitor with an IC₅₀ of 0.74 μM. Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway and increases apoptosis in lung cancer cells.

HY-132175

CK2 inhibitor 2	Inhibitor	98.51%
CK2 inhibitor 2 is a potent, selective and orally active inhibitor of CK2, with an IC₅₀ of 0.66 nM. CK2 inhibitor 2 shows high selectivity for Clk2 (IC₅₀=32.69 nM)/CK2. CK2 inhibitor 2 exhibits favorable antiproliferative and antitumor activity.

HY-110052

TBCA	Inhibitor	99.45%
TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC₅₀ of 110 nM and a K_i of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases.

HY-156816

ON 108600	Inhibitor	99.73%
ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC₅₀s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity.

HY-108606

PI-828	Inhibitor	99.62%
PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC₅₀s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively.

HY-124833

Quinalizarin	Inhibitor
Quinalizarin is a potent, selective and cell-permeable protein kinase CK2 inhibitor with an K_i of ~50 nM and an IC₅₀ of 110 nM. Quinalizarin can induce apoptosis of certain cancer cells.

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