1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
  2. Casein Kinase
  3. TBCA


Cat. No.: HY-110052 Purity: 99.60%
Handling Instructions

TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC50 of 110 nM and a Ki of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases.

For research use only. We do not sell to patients.

TBCA Chemical Structure

TBCA Chemical Structure

CAS No. : 934358-00-6

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5 mg USD 285 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC50 of 110 nM and a Ki of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases[1][2].

IC50 & Target[1]


110 nM (IC50)


77 nM (Ki)

In Vitro

TBCA (0-100 μM; 24 hours) shows a drastic effect on Jurkat cells viability[1].
TBCA also inhibits CK2 double mutant (Val66 Ile174) with an IC50 of 0.68 μM[1].
TBCA dose-dependently inhibits platelet aggregation and secretion induced by various agonists including 2-MeSADP, AYPGKF, SFLLRN, and CRP. TBCA also inhibits phosphorylation of PDK1, Akt, and GSK3β induced by AYPGKF[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Jurkat cells
Concentration: 0-100 μM
Incubation Time: 24 hours
Result: The viability of Jurkat cells was reduced.
Molecular Weight





Room temperature in continental US; may vary elsewhere.


-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (215.64 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1564 mL 10.7819 mL 21.5638 mL
5 mM 0.4313 mL 2.1564 mL 4.3128 mL
10 mM 0.2156 mL 1.0782 mL 2.1564 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (5.39 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.39 mM); Clear solution

*All of the co-solvents are provided by MCE.

Purity: 99.60%

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