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  2. Casein Kinase
  3. TBCA

TBCA 

Cat. No.: HY-110052 Purity: >98.0%
Handling Instructions

TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC50 of 110 nM and a Ki of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases.

For research use only. We do not sell to patients.

TBCA Chemical Structure

TBCA Chemical Structure

CAS No. : 934358-00-6

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5 mg USD 285 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC50 of 110 nM and a Ki of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases[1][2].

IC50 & Target[1]

CK2

110 nM (IC50)

CK2

77 nM (Ki)

In Vitro

TBCA (0-100 μM; 24 hours) shows a drastic effect on Jurkat cells viability[1].
TBCA also inhibits CK2 double mutant (Val66 Ile174) with an IC50 of 0.68 μM[1].
TBCA dose-dependently inhibits platelet aggregation and secretion induced by various agonists including 2-MeSADP, AYPGKF, SFLLRN, and CRP. TBCA also inhibits phosphorylation of PDK1, Akt, and GSK3β induced by AYPGKF[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Jurkat cells
Concentration: 0-100 μM
Incubation Time: 24 hours
Result: The viability of Jurkat cells was reduced.
Molecular Weight

463.74

Formula

C₉H₄Br₄O₂

CAS No.

934358-00-6

SMILES

OC(/C=C/C1=C(C(Br)=C(Br)C(Br)=C1)Br)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References

Purity: >98.0%

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Keywords:

TBCACasein KinaseJurkatcellsviabilityselectivityplateletaggregationInhibitorinhibitorinhibit

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TBCA
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