934358-00-6
934358-00-6
Chemical Structure
TBCA
- CAS No.: 934358-00-6
- Formula:C9H4Br4O2
- Molecular Weight:463.74
IUPAC Name: (E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid
InChIKey: SVJQCVOKYJWUBC-OWOJBTEDSA-N
SMILES: OC(/C=C/C1=C(C(Br)=C(Br)C(Br)=C1)Br)=O
Biological Activity: TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC50 of 110 nM and a Ki of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TBCA | 99.45% | TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC50 of 110 nM and a Ki of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases. | ||||||||||||||||||||
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References
- [1]. Pagano MA, et al. Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitors. Chembiochem. 2007;8(1):129-139. [Content Brief]
- [2]. Ryu SY, Kim S. Evaluation of CK2 inhibitor (E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid (TBCA) in regulation of platelet function. Eur J Pharmacol. 2013;720(1-3):391-400. [Content Brief]
Keywords
