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  3. PI-828

PI-828 

Cat. No.: HY-108606 Purity: >98.0%
Handling Instructions

PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively.

For research use only. We do not sell to patients.

PI-828 Chemical Structure

PI-828 Chemical Structure

CAS No. : 942289-87-4

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 170 In-stock
Estimated Time of Arrival: December 31
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 410 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively[1].

IC50 & Target[1]

p110α

173 nM (IC50)

CK2

149 nM (IC50)

CK2α2

1.127 μM (IC50)

In Vitro

PI-828 (0.01-100 μM) exhibits cytotoxic effect on the 4T1 breast cancer cells and 4306 ovarian cancer cells[2].
PI-828 (0.78-3.12 µM; 48 hours) decreases caspase 3 activation; higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis[3].

Cell Viability Assay[2]

Cell Line: 4T1 breast cancer cells and 4306 ovarian cancer cells
Concentration: 0.01, 0.1, 1, 10 and 100 μM
Incubation Time:
Result: Exhibited cytotoxic effect.

Apoptosis Analysis[3]

Cell Line: Human embryonic carcinoma NCCIT cells
Concentration: 0.78, 1.56, 3.12, 6.25, 12.5 μM
Incubation Time: 48 hours
Result: Concentrations of ranging from 0.78 to 3.12 µM decreased caspase 3 activation; higher concentrations caused apoptosis.
Molecular Weight

322.36

Formula

C₁₉H₁₈N₂O₃

CAS No.

942289-87-4

SMILES

O=C1C=C(N2CCOCC2)OC3=C(C4=CC=C(N)C=C4)C=CC=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

PI-828PI828PI 828PI3KCasein KinasePhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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PI-828
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HY-108606
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