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Silmitasertib sodium salt

(Synonyms: CX-4945 sodium salt)
59 Cited Publications
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Based on 59 publication(s) in Google Scholar

Silmitasertib sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'.

For research use only. We do not sell to patients.

  • Purity: 99.87%
  • CAS No.: 1309357-15-0
  • Formula: C19H11ClN3NaO2
  • Molecular Weight:371.75
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Silmitasertib sodium salt Chemical Structure
    Silmitasertib sodium salt Chemical Structure
  • Experimental Validation Results for Silmitasertib sodium salt
  • Experimental Validation Results for Silmitasertib sodium salt
  • Experimental Validation Results for Silmitasertib sodium salt
  • Experimental Validation Results for Silmitasertib sodium salt
  • Experimental Validation Results for Silmitasertib sodium salt
  • Experimental Validation Results for Silmitasertib sodium salt
  • Experimental Validation Results for Silmitasertib sodium salt
CAS No.: 1309357-15-0
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Silmitasertib sodium salt Chemical Structure
    Silmitasertib sodium salt Chemical Structure
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    Silmitasertib sodium salt purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2024 Apr 22;10(1):185. [Abstract]

    Customer Validation
     CK2α kinase activity was measured after treatment with silmitasertib (20 μM, 24 h). Cell lysates were used for in vitro kinase assay to detect the intensity of phosphorylated substrate.

  • 1/16

    Silmitasertib sodium salt purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2021 Mar;23(3):257-267. [Abstract]

    Customer Validation
     BM2-TGC cells expressing either vector or DACT1 were treated with Wnt3a +/− Silmitasertib at 5 μM for 24h.

  • 1/16

    Silmitasertib sodium salt purchased from MedChemExpress. Usage Cited in: Cells. 2021 Jan 18;10(1):181. [Abstract]

    Customer Validation
     w.t. SK-N-BE cells were treated with CX-4945 (5-10 μM, 24-48 h) at the indicated time and concentration conditions. 30 μg proteins from lysates were analyzed by WB for the HIF-1α levels. Actin was used as loading control.

  • 1/16

    Silmitasertib sodium salt purchased from MedChemExpress. Usage Cited in: Cells. 2021 Jan 18;10(1):181. [Abstract]

    Customer Validation
     SK-N-BE and U2OS cells were analyzed for the extracellular lactate secreted in the culture medium in 6 h, in the absence or in the presence of the indicated concentrations of CX-4945 (5-15 μM).

  • 1/16

    Silmitasertib sodium salt purchased from MedChemExpress. Usage Cited in: Cells. 2021 Jan 18;10(1):181. [Abstract]

    Customer Validation
     SK-N-BE cells glycolytic stress test profile, upon treatment with vehicle (control) or the indicated concentration of CX-4945 (2-5 ，μM) for 5 h before running the Seahorse experiment.

  • 1/16

    Silmitasertib sodium salt purchased from MedChemExpress. Usage Cited in: Oncol Rep. 2017 Feb;37(2):1141-1147. [Abstract]

    Customer Validation
     CX-4945 increases the expression of apoptosis markers. Western blot analysis reveals that CX-4945 treatment increases the expression of cleaved PARP or cleaved caspase-3. CX-4945 treatment decreases the expression of Bcl-2 or Bcl-xL. The experiment is performed in triplicate, producing similar results.

  • 1/16

    Silmitasertib sodium salt purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 Aug 16;7(33):53191-53203. [Abstract]

    Customer Validation
     MPNST cell lines show a decrease in CK2 activity in response to escalating CX-4945 concentrations (24 h) as measured by a western blot analysis using anti-CK2 substrate, and to undergo apoptosis as indicated by increased cleaved PARP.

  • Silmitasertib sodium salt