1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR Inhibitors

FGFR Inhibitors

FGFR

FGFR1

FGFR2

FGFR3

FGFR4

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

FGFR Inhibitors
Product Name FGFR FGFR1 FGFR2 FGFR3 FGFR4 Purity
Lenvatinib  
FGFR1, IC50: 46 nM
      99.87%
Nintedanib  
FGFR1, IC50: 69 nM
FGFR2, IC50: 37 nM
FGFR3, IC50: 108 nM
  99.97%
Ponatinib  
FGFR1, IC50: 2.2 nM
      99.13%
Erdafitinib  
FGFR1, IC50: 1.2 nM
FGFR2, IC50: 2.5 nM
FGFR3, IC50: 3.0 nM
FGFR4, IC50: 5.7 nM
99.66%
Infigratinib  
FGFR1, IC50: 0.9 nM
FGFR2, IC50: 1.4 nM
FGFR3, IC50: 1 nM
FGFR4, IC50: 60 nM
99.55%
FGFR4-IN-1        
FGFR4, IC50: 0.7 nM
99.88%
(Z)-Orantinib  
FGFR1, IC50: 1.2 μM
      99.02%
FGFR1/DDR2 inhibitor 1  
FGFR1, IC50: 31.1 nM
      99.03%
AZD4547  
FGFR1, IC50: 0.2 nM
FGFR2, IC50: 2.5 nM
FGFR3, IC50: 1.8 nM
FGFR4, IC50: 165 nM
99.68%
Pemigatinib  
FGFR1, IC50: 0.4 nM
FGFR2, IC50: 0.5 nM
FGFR3, IC50: 1.2 nM
FGFR4, IC50: 30 nM
99.88%
Pazopanib  
FGFR1, IC50: 140 nM
      99.68%
SU 5402  
FGFR1, IC50: 30 nM
      99.39%
PD173074  
FGFR1, IC50: 25 nM
      99.67%
Fisogatinib        
FGFR4, IC50: 5 nM
99.87%
Futibatinib  
FGFR1, IC50: 3.9 nM
FGFR2, IC50: 1.3 nM
wild-type FGFR2, IC50: 0.3 nM
FGFR2 V5651, IC50: 1-3 nM
FGFR2 N550H, IC50: 3.6 nM
FGFR2 E566G, IC50: 2.4 nM
FGFR3, IC50: 1.6 nM
FGFR4, IC50: 8.3 nM
98.80%
Nintedanib esylate  
FGFR1, IC50: 69 nM
FGFR2, IC50: 37 nM
FGFR3, IC50: 108 nM
  99.93%
Dovitinib  
FGFR1, IC50: 8 nM
 
FGFR3, IC50: 9 nM
  97.18%
Rogaratinib  
FGFR1
FGFR2
FGFR3
FGFR4
99.86%
LY2874455  
FGFR1, IC50: 2.8 nM
FGFR2, IC50: 2.6 nM
FGFR3, IC50: 6.4 nM
FGFR4, IC50: 6 nM
98.06%
BLU9931  
FGFR1, IC50: 591 nM
FGFR2, IC50: 493 nM
FGFR3, IC50: 150 nM
FGFR4, IC50: 3 nM
≥98.0%
KW-2449  
FGFR1, IC50: 36 nM
      99.85%
Roblitinib        
FGFR4, IC50: 1.9 nM
≥98.0%
Gandotinib    
FGFR2, IC50: 32 nM
FGFR3, IC50: 106 nM
  99.96%
Lucitanib  
FGFR1, IC50: 17.5 nM
FGFR2, IC50: 82.5 nM
    99.32%
Pazopanib Hydrochloride  
FGFR1, IC50: 140 nM
      99.84%
PD-166866  
FGFR1, IC50: 52.4 nM
      99.97%
Ferulic acid  
FGFR1, IC50: 3.78 μM
FGFR2, IC50: 12.5 μM
    99.87%
Alofanib    
FGFR2
    99.83%
CH5183284  
FGFR1, IC50: 9.3 nM
FGFR2, IC50: 7.6 nM
FGFR3, IC50: 22 nM
FGFR4, IC50: 290 nM
99.73%
PRN1371  
FGFR1, IC50: 0.6 nM
FGFR2, IC50: 1.3 nM
FGFR3, IC50: 4.1 nM
FGFR4, IC50: 19.3 nM
99.72%
CP-547632
FGFR, IC50: 9 nM
        ≥99.0%
Sulfatinib  
FGFR1
      98.01%
Lenvatinib mesylate  
FGFR1, IC50: 46 nM
      99.86%
PF 477736      
FGFR3, IC50: 23 nM
  99.21%
Derazantinib  
FGFR1, IC50: 4.5 nM
FGFR2, IC50: 1.8 nM
FGFR3, IC50: 4.5 nM
  99.18%
ENMD-2076  
FGFR1, IC50: 92.7 nM
FGFR2, IC50: 70.8 nM
    99.12%
CP-547632 hydrochloride
FGFR, IC50: 9 nM
        98.24%
TG 100801  
FGFR1, IC50: 2 nM
FGFR2, IC50: 16 nM
    ≥95.0%
Dovitinib lactate  
FGFR1, IC50: 8 nM
 
FGFR3, IC50: 9 nM
  99.96%
Orantinib  
FGFR1, Ki: 1.2 μM
      98.80%
FIIN-2  
FGFR1, IC50: 3.1 nM
FGFR2, IC50: 4.3 nM
FGFR3, IC50: 27 nM
FGFR4, IC50: 45 nM
99.95%
S49076  
FGFR1, IC50: 18 nM
FGFR1V561M, IC50: 23 nM
FGFR2, IC50: 17 nM
FGFR2N549H, IC50: 19 nM
FGFR3, IC50: 15 nM
  98.62%
ODM-203  
FGFR1, IC50: 11 nM
FGFR2, IC50: 16 nM
FGFR3, IC50: 6 nM
FGFR4, IC50: 35 nM
99.33%
R1530  
FGFR1, IC50: 28 nM
      99.06%
ASP5878  
FGFR1, IC50: 0.47 nM
FGFR2, IC50: 0.6 nM
FGFR3, IC50: 0.74 nM
FGFR4, IC50: 3.5 nM
99.71%
ENMD-2076 Tartrate  
FGFR1, IC50: 92.7 nM
FGFR2, IC50: 70.8 nM
    98.87%
EOC317  
FGFR1, IC50: 6 nM
      98.11%
SSR128129E  
FGFR1, IC50: 1.9 μM
      99.86%
FIIN-3  
FGFR1, IC50: 13.1 nM
FGFR2, IC50: 21 nM
FGFR3, IC50: 31.4 nM
FGFR4, IC50: 35.3 nM
98.13%
Tyrosine kinase-IN-1  
FGFR1, IC50: 2 nM
      99.47%
Infigratinib phosphate  
FGFR1, IC50: 0.9 nM
FGFR2, IC50: 1.4 nM
FGFR3, IC50: 1 nM
FGFR4, IC50: 60 nM
97.74%
PD-161570  
FGFR1, IC50: 39.9 nM
FGFR1, Ki: 42 nM
FGFR1 autophosphorylation, IC50: 622 nM
     
TG 100572  
FGFR1, IC50: 2 nM
FGFR2, IC50: 16 nM
   
Dovitinib lactate hydrate  
FGFR1, IC50: 8 nM
 
FGFR3, IC50: 9 nM
 
E7090 succinate  
FGFR1, IC50: 0.71 nM
FGFR2, IC50: 0.50 nM
FGFR3, IC50: 1.2 nM
FGFR4, IC50: 120 nM
CPL304110  
FGFR1, IC50: 0.75 nM
FGFR2, IC50: 0.5 nM
FGFR3, IC50: 3.05 nM
 
FGFR4-IN-4        
FGFR4
ARQ 069  
unphosphorylated FGFR1, IC50: 0.84 μM
FGFR1 autophosphorylation, IC50: 2.8 μM
unphosphorylated FGFR2, IC50: 1.23 μM
FGFR2 autophosphorylation, IC50: 1.9 μM
   
PD-089828  
FGFR1, IC50: 0.15 μM
FGFR1, Ki: 0.14 μM
     
FIIN-1  
FGFR1, Kd: 2.8 nM
FGFR1, IC50: 9.2 nM
FGFR2, Kd: 6.9 nM
FGFR2, IC50: 6.2 nM
FGFR3, Kd: 5.4 nM
FGFR3, IC50: 11.9 nM
FGFR4, Kd: 120 nM
FGFR4, IC50: 189 nM
CP-547632 TFA
FGFR, IC50: 9 nM
        99.42%
Ponatinib D8  
FGFR1, IC50: 2.2 nM
     
TG 100801 Hydrochloride  
FGFR1, IC50: 2 nM
FGFR2, IC50: 16 nM
   
SSR128129E free acid  
FGFR1, IC50: 1.9 μM