2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N7107
    Fenchyl alcohol
    		Inhibitor
    Fenchyl alcohol is a monoterpene alcohol that can be used as a fragrance. Fenchyl alcohol has antifungal activity and can inhibit the formation of biofilms and hyphae of Candida albicans. Fenchyl alcohol also has a strong inhibitory effect on the rumen microbial activity of sheep and deer.
    Fenchyl alcohol
  • HY-P1791B
    Lactoferrin (17-41) acetate
    		Inhibitor 99.65%
    Lactoferrin 17-41 (Lactoferricin B) acetate, a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 acetate has antitumor activities.
    Lactoferrin (17-41) acetate
  • HY-10863S
    Anandamide-d8
    		Inhibitor 99.90%
    Anandamide-d8 is a deuterated labeled Anandamide. Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis.
    Anandamide-d<sub>8</sub>
  • HY-130173
    Bafilomycin C1
    		Inhibitor 99.9%
    Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H+-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi. Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC).
    Bafilomycin C1
  • HY-W037200
    2,3,5-Tri-O-benzyl-D-ribose
    		Inhibitor 98.56%
    2,3,5-Tri-O-benzyl-D-ribose (Compound 1) is an effective inhibitor of Botrytis cinerea chitin synthase (CHS) with an IC50 value of 1.8 μM. 2,3,5-Tri-O-benzyl-D-ribose exhibits antifungal activity and is able to inhibit the B. cinerea BD90 strain, with a MIC value of 190 μM.
    2,3,5-Tri-O-benzyl-D-ribose
  • HY-W007626
    3,5-Dimethoxybenzaldehyde
    		Inhibitor 99.98%
    3,5-Dimethoxybenzaldehyde is an antifungal agent. 3,5-Dimethoxybenzaldehyde exhibits antifungal activity against Saccharomyces cerevisiae cell wall integrity mutants (slt2Δ and bck1Δ) and Aspergillus fumigatus MAPK mutants (sakAΔ and mpkCΔ).
    3,5-Dimethoxybenzaldehyde
  • HY-B0852R
    Tebuconazole (Standard)
    		Inhibitor
    Tebuconazole (Standard) is the analytical standard of Tebuconazole. This product is intended for research and analytical applications. Tebuconazole is an orally active agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively. Tebuconazole induces lipid accumulation and oxidative stress in HepG2 Cells. Tebuconazole decreases MAC-T cells viability and proliferation, induces ER-stress-mediated apoptosis and increases oxidative stress levels in MAC-T cells.
    Tebuconazole (Standard)
  • HY-B0348
    Liranaftate
    		Inhibitor 99.68%
    Liranaftate (Piritetrate) is a squalene epoxidase inhibitor with anti-fungicidal activities. Liranaftate can be used for the research of dermatophytes. Liranaftate also suppresses fungal element-promoted production of IL-8 and experimental inflammation.
    Liranaftate
  • HY-B0238R
    Amorolfine hydrochloride (Standard)
    		Inhibitor
    Amorolfine (hydrochloride) (Standard) is the analytical standard of Amorolfine (hydrochloride). This product is intended for research and analytical applications. Amorolfine (Ro 14-4767/002) hydrochloride is a potent anti-fungal agent. Amorolfine hydrochloride inhibits ergosterol biosynthesis. Amorolfine hydrochloride has the potential for the research of Neoscytalidium dimidiatum onychomycosis.
    Amorolfine hydrochloride (Standard)
  • HY-121935
    Tecnazene
    		Inhibitor 99.96%
    Tecnazene is a dinitroaromatic fungicide and plant growth regulator. Tecnazene binds irreversibly to human skin tissues and exhibits acute toxicity in Rattus norvegicus (brown rat). Tecnazene exerts sprouting-inhibiting and antifungal activities by inhibiting the sprouting of potato tuber buds and blocking the growth and reproduction of fungi that cause dry rot. Tecnazene has significant antifungal and sprouting-inhibiting activities, and shows high toxicity to aquatic organisms such as freshwater fish and crustaceans. Tecnazene is used for sprouting inhibition and dry rot control during potato storage.
    Tecnazene
  • HY-B1143
    Broxaldine
    		Inhibitor 99.88%
    Broxaldine (Brobenzoxaldine) is an antiprotozoal agent. Broxaldine inhibits Clostridium difficile with a MIC value of 4 µM, and has antifungal effects.
    Broxaldine
  • HY-N12804
    δ-Cadinol
    		Inhibitor 98.0%
    δ-Cadinol ((-)-Torreyol) is a sesquiterpenoid compound and fungicide produced by the basidiomycete Boreostereum vibrans. δ-Cadinol is used for the research of fungal infections.
    δ-Cadinol
  • HY-N0903
    Dihydrochelerythrine
    		Inhibitor 99.39%
    Dihydrochelerythrine is a natural compound isolated from Corydalis yanhusuo; has antifungal activity.
    Dihydrochelerythrine
  • HY-N0709R
    Coumarin (Standard)
    		Inhibitor
    Coumarin (Standard) is the analytical standard of Coumarin. This product is intended for research and analytical applications. Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity.
    Coumarin (Standard)
  • HY-B1119S
    Triclosan-d3
    		Inhibitor 98.22%
    Triclosan-d3 is the deuterium labeled Triclosan. Triclosan is an antibacterial and antifungal agent found in consumer products, including soaps, detergents, toys, and surgical cleaning treatments.
    Triclosan-d<sub>3</sub>
  • HY-B2205
    Magnesium silicate
    		Inhibitor
    Magnesium silicate (Activated magnesium silicate) is an orally active compound composed of magnesium oxide (MgO) and silicon dioxide (SiO2). Magnesium silicate can be used in the preparation of food additives, antacids and anti-ulcer agents. Magnesium silicate is also a piezoelectric biomaterial, deodorant, decolorizing agent and antifungal agent.
    Magnesium silicate
  • HY-17520
    Penthiopyrad
    		Inhibitor 99.89%
    Penthiopyrad (MTF-753) is a carboxamide Fungicide. Penthiopyrad inhibits SDH. Penthiopyrad exhibits broad-spectrum antifungal activity, being effective not only against Basidiomycetes, but also against Ascomycetes and Deuteromycetes. Penthiopyrad inhibits the mycelial growth of Alternaria mali, Botrytis cinerea, Monilinia mali, Rhizoctonia solani and Sclerotinia sclerotiorum on PDA medium, with EC50 values ranging from <0.4 ppm to 0.34 ppm and MIC values ranging from 6.6 ppm to 47.9 ppm.
    Penthiopyrad
  • HY-B1858
    Isoprothiolane
    		Inhibitor 99.91%
    Isoprothiolane is a blast fungicide with antifungal, anti-inflammatory and insecticidal activities. Isoprothiolane primarily acts on fungi during the penetration and growth stages of infecting hyphae. Isoprothiolane can be used as an insecticide, pesticide, etc. In addition, Isoprothiolane can reduce serum phospholipid and total lipid concentrations, regulating lipid metabolism. Isoprothiolane is also used in the research of fatty liver.
    Isoprothiolane
  • HY-N3557
    Cauloside A
    		Inhibitor 99.75%
    Cauloside A (Leontoside A) is a saponin isolated from Dipsacus asper roots. Cauloside A has potent antifungal activity.
    Cauloside A
  • HY-N7012
    7,3',4'-Tri-O-methylluteolin
    		Inhibitor 99.28%
    7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) is a flavonoid with multiple biological activities. 7,3',4'-Tri-O-methylluteolin inhibits soybean lipoxygenase (LOX), with an IC50 value of 23.97 µg/mL. 7,3',4'-Tri-O-methylluteolin possesses anti-inflammatory effects in Lipopolysaccharides (HY-D1056) (LPS)-induced RAW 264.7 macrophages. 7,3',4'-Tri-O-methylluteolin inhibits the binding of MDM2 with p53 and induces apoptosis in MCF-7 breast cancer cells. 7,3',4'-Tri-O-methylluteolin also has antioxidant, antifungal and antitrypanosomal activitiessup>[4]sup>[5].
    7,3',4'-Tri-O-methylluteolin
Cat. No. Product Name / Synonyms Application Reactivity