Tecnazene

Cat. No.: HY-121935 Purity: 99.96%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Tecnazene is a dinitroaromatic fungicide and plant growth regulator. Tecnazene binds irreversibly to human skin tissues and exhibits acute toxicity in Rattus norvegicus (brown rat). Tecnazene exerts sprouting-inhibiting and antifungal activities by inhibiting the sprouting of potato tuber buds and blocking the growth and reproduction of fungi that cause dry rot. Tecnazene has significant antifungal and sprouting-inhibiting activities, and shows high toxicity to aquatic organisms such as freshwater fish and crustaceans. Tecnazene is used for sprouting inhibition and dry rot control during potato storage.

For research use only. We do not sell to patients.

Tecnazene Chemical Structure

CAS No. : 117-18-0

Size	Stock	Quantity

Free Sample (0.1 - 0.2 mg)	Apply Now
Free Sample (0.1 - 0.2 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Tecnazene:

Tecnazene (Standard) Get quote

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Tecnazene is mainly applied in the agricultural field as a dual-effect pesticide for sprouting inhibition and dry rot control during potato storage. It is also used in studies on the in vitro human skin permeation properties of highly lipophilic chlorinated aromatic compounds, as well as in the calibration and optimization of transdermal absorption and diffusion models^[2].
In in vitro human skin permeation assays, the percutaneous absorption rate of Tecnazene reaches 22-33% under occlusive conditions and 2.2-6.1% under non-occlusive conditions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2 (Absorption)	T_max	T_1/2 (Elimination)
Rat^[4]	300 mg/kg	p.o.	0.38 h	2 h	8.6 h
Rat^[4]	300 mg/kg	p.o.	0.38 h	2 h	8.6 h

In Vivo

Tecnazene is metabolized in organisms via pathways such as glutathione conjugation and nitro substitution, and can form metabolites including mercapturic acid conjugates and tetrachloroanisole. It undergoes rapid bioconcentration and rapid excretion in aquatic organisms^[3].
Tecnazene shows high toxicity to aquatic organisms such as freshwater fish and crustaceans, with a 96-hour LC₅₀ of 270-2340 μg/L^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

260.89

Formula

C₆HCl₄NO₂

CAS No.

117-18-0

Appearance

Solid

Color

White to off-white

SMILES

ClC1=C(C(Cl)=C(C=C1Cl)Cl)[N+]([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 233.33 mg/mL (894.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8330 mL	19.1652 mL	38.3303 mL
5 mM	0.7666 mL	3.8330 mL	7.6661 mL
10 mM	0.3833 mL	1.9165 mL	3.8330 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.96%

Select Batch:

Data Sheet (277 KB) SDS (761 KB)

COA (253 KB) HNMR (237 KB) RP-HPLC (244 KB)

Handling Instructions (2659 KB)

References

[1]. Pouretedal H R, et al. Prediction of toxicity of nitroaromatic compounds through their molecular structures[J]. Journal of the Iranian Chemical Society, 2011, 8(1): 78-89.

[2]. Bhatt V D, et al. Permeation of tecnazene through human skin in vitro as assessed by HS-SPME and GC-MS[J]. Environmental science & technology, 2008, 42(17): 6587-6592.

[3]. Lappin G J, et al. Metabolism of 2, 3, 5, 6-tetrachloronitrobenzene (tecnazene) in rat[J]. Xenobiotica, 1996, 26(1): 65-77.

[4]. Whale G, et al. The toxicity of tecnazene, a potato sprouting inhibitor, to freshwater fauna[J]. Chemosphere, 1988, 17(6): 1205-1217.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.8330 mL	19.1652 mL	38.3303 mL	95.8258 mL
	5 mM	0.7666 mL	3.8330 mL	7.6661 mL	19.1652 mL
	10 mM	0.3833 mL	1.9165 mL	3.8330 mL	9.5826 mL
	15 mM	0.2555 mL	1.2777 mL	2.5554 mL	6.3884 mL
	20 mM	0.1917 mL	0.9583 mL	1.9165 mL	4.7913 mL
	25 mM	0.1533 mL	0.7666 mL	1.5332 mL	3.8330 mL
	30 mM	0.1278 mL	0.6388 mL	1.2777 mL	3.1942 mL
	40 mM	0.0958 mL	0.4791 mL	0.9583 mL	2.3956 mL
	50 mM	0.0767 mL	0.3833 mL	0.7666 mL	1.9165 mL
	60 mM	0.0639 mL	0.3194 mL	0.6388 mL	1.5971 mL
	80 mM	0.0479 mL	0.2396 mL	0.4791 mL	1.1978 mL
	100 mM	0.0383 mL	0.1917 mL	0.3833 mL	0.9583 mL

Tecnazene Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tecnazene117-18-0FungalEnvironmental PollutantsEnvironmental Contaminantsratsnitro groupsQSAR-based correlation modelchlorine substituentsdinitroaromatic toxicantnitroaromatic categoryInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *