1. Anti-infection
  2. Fungal
  3. Liranaftate

Liranaftate (Synonyms: Piritetrate; M-732)

Cat. No.: HY-B0348 Purity: 99.98%
Handling Instructions

Liranaftate (Piritetrate) is a squalene epoxidase inhibitor with anti-fungicidal activities. Liranaftate can be used for the research of dermatophytes. Liranaftate also suppresses fungal element-promoted production of IL-8 and experimental inflammation.

For research use only. We do not sell to patients.

Liranaftate Chemical Structure

Liranaftate Chemical Structure

CAS No. : 88678-31-3

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Description

Liranaftate (Piritetrate) is a squalene epoxidase inhibitor with anti-fungicidal activities. Liranaftate can be used for the research of dermatophytes. Liranaftate also suppresses fungal element-promoted production of IL-8 and experimental inflammation[1][2][3][4].

In Vitro

Liranaftate showed excellent fungistatic activity against the conidia of T. rubrum. For each of these agents, the MIC after 14 days of contact was 0.009 g/ml. The liranaftate-induced decrease in the MCC occurred from 9 days onwards; MCC at 14 days was 0.039 g/ml [1]. In time-kill studies, liranaftate showed the greatest decrease to a below detection limit in viable counts of T rubrum. The degree of killing of the strain by amorolfine was not greater than that seen by liranaftate, and little reduction of the viable counts by luliconazole and ketoconazole was observed irrespective of concentrations of the agents [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

328.43

Formula

C₁₈H₂₀N₂O₂S

CAS No.

88678-31-3

SMILES

S=C(OC1=CC=C2CCCCC2=C1)N(C3=NC(OC)=CC=C3)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (304.48 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0448 mL 15.2239 mL 30.4479 mL
5 mM 0.6090 mL 3.0448 mL 6.0896 mL
10 mM 0.3045 mL 1.5224 mL 3.0448 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (7.61 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (7.61 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.61 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

LiranaftatePiritetrate M-732M732M 732M-732Fungalsqualeneepoxidaseanti-fungaldermatophytesIL-8inflammationInhibitorinhibitorinhibit

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Liranaftate
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