2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health[1][2][3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets[1][2][3].

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-128788A
    ddhCTP trisodium solution (100 mM)
    ddhCTP trisodium solution (100 mM) is an endogenously produced pyrimidine base analog with a Kd of 17.0 nM for LLDH and an IC50 of 55.8 μM for GAPDH. By inhibiting key metabolic enzymes such as GAPDH, ddhCTP trisodium reduces glycolytic flux and shifts metabolic flow toward the pentose phosphate pathway, thereby regulating the redox balance of cells. As a competitive CTP analog, ddhCTP trisodium terminates RNA synthesis by flavivirus RdRps and SARS-CoV-2 RdRp, and inhibits Zika virus replication in vivo. ddhCTP trisodium can be used in studies related to viral infections, COVID-19 and Zika virus infections.
    ddhCTP trisodium solution (100 mM)
  • HY-114245R
    Se-Methylselenocysteine (Standard)
    Risedronic acid (Standard) is the analytical standard of Risedronic acid. This product is intended for research and analytical applications. 0
    Se-Methylselenocysteine (Standard)
  • HY-N6685
    3-Acetyldeoxynivalenol
    		98.38%
    3-Acetyldeoxynivalenol (3-AcDON; 3ADON), a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative, is a brain-penetrant Fusarium mycotoxin. 3-Acetyldeoxynivalenol induces mRNA expression and production of inflammatory chemokine IL-8 in intestinal cells.
    3-Acetyldeoxynivalenol
  • HY-N6979R
    Crustecdysone (Standard)
    Crustecdysone (Standard) is the analytical standard of Crustecdysone. This product is intended for research and analytical applications. Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system. Crustecdysone is an active metabolite of Ecdysone (HY-N0179).
    Crustecdysone (Standard)
  • HY-113457S
    11-Oxo etiocholanolone-d5
    		99.90%
    11-Oxo etiocholanolone-d5 (11-Ketoetiocholanolone-d5) is the deuterium labeled 11-Oxo etiocholanolone (HY-113457). 11-Oxo etiocholanolone (11-Ketoetiocholanolone) is a steroid. 11-Oxo etiocholanolone is a key indicator for detecting cortisol metabolites in feces and urine. 11-Oxo etiocholanolone has the potential to be a pheromone.
    11-Oxo etiocholanolone-d<sub>5</sub>
  • HY-N18050
    Petrobactin
    Petrobactin is a photoreactive siderophore. Petrobactin can be produced by the oil-degrading marine bacterium Marinobacter hydrocarbonoclasticus. Petrobactin can be synthesized by Bacillus anthracis str. Sterne under conditions of iron starvation. Petrobactin readily undergoes a light-mediated decarboxylation reaction when bound to Fe(III).
    Petrobactin
  • HY-N13363
    2-Keto-3-deoxy-6-phosphogluconate
    2-keto-3-deoxy-6-phosphogluconate is an endogenous metabolite found in Escherichia coli, and a key intermediate in the Entner-Doudoroff (ED) pathway, as well as in the degradation pathways of sugar acids and sugar polymers in human and plant pathogens. It is produced by the catalytic action of KDPG aldolase.
    2-Keto-3-deoxy-6-phosphogluconate
  • HY-116865
    Equilenin
    		≥98.0%
    Equilenin is a B-ring unsaturated estrogen and one of the main ingredients in Premarin, a drug commonly used in estrogen replacement therapy. Equilenin can bind to estrogen receptors in the body and exert effects similar to endogenous estrogen. Equilenin can be used in estrogen replacement therapy and breast cancer research.
    Equilenin
  • HY-150773S1
    Guanosine triphosphate-d14 dilithium
    Guanosine triphosphate-d14 (GTP-d14) dilithium is a deuterium labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate is a native nucleotide. The derivatives of GTP may be used as specific inhibitors against COVID-19.
    Guanosine triphosphate-d<sub>14</sub> dilithium
  • HY-B0158S5
    Cytidine-13C9,15N3
    		98.9%
    Cytidine-13C9,15N3 is the 13C and 15N labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
    Cytidine-<sup>13</sup>C<sub>9</sub>,<sup>15</sup>N<sub>3</sub>
  • HY-W060074
    1-Acetyl-β-carboline
    1-Acetyl-β-carboline is a metabolite of Streptomyces kasugaensis and antibacterial agent. 1-Acetyl-β-carboline increases tyrosinase activity, reduces ERK phosphorylation. 1-Acetyl-β-carboline exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains with MICs ranging from 128 to 256 ug/mL. 1-Acetyl-β-carboline increases the melanin.
    1-Acetyl-β-carboline
  • HY-W092109R
    H-Phe-Trp-OH (Standard)
    H-Phe-Trp-OH (Phenylalanyltryptophan; Phe-Trp) (Standard) is an analytical standard of H-Phe-Trp-OH (HY-W092109). This product is intended for research and analytical applications. H-Phe-Trp-OH, a dipeptide, is an endogenous metabolite. H-Phe-Trp-OH can be used for the research of tic disorder.
    H-Phe-Trp-OH (Standard)
  • HY-101981S
    Uridine 5'-monophosphate-15N2
    		98.0%
    Uridine 5'-monophosphate-15N2 (5'-​Uridylic acid-15N2) is the 15N labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea.
    Uridine 5'-monophosphate-<sup>15</sup>N<sub>2</sub>
  • HY-W582827
    RuPhos Pd G1 methyl t-butyl ether adduct (MTBE)
    RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) is a highly efficient catalyst with excellent cross-coupling activity. RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) is widely used in organic synthesis and can be used to promote various reactions to build complex molecular structures. RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) has good adaptability to temperature and reaction conditions, which enables it to exhibit excellent catalytic performance in different reaction systems.
    RuPhos Pd G1 methyl t-butyl ether adduct (MTBE)
  • HY-W011527R
    Xanthosine (Standard)
    Xanthosine (Standard) is the analytical standard of Xanthosine. This product is intended for research and analytical applications. Xanthosine is a nucleoside derived from xanthine and ribose. Xanthosine activates the AMPK/FoxO1/AKT/GSK3β signaling cascade. Xanthosine promotes cell proliferation and regulates blood glucose metabolism. Xanthosine increases milk production in cows and goats. Xanthosine is used in mammary stem cell and type 2 diabetes research.
    Xanthosine (Standard)
  • HY-B1744S
    Pyridoxal phosphate-d5
    		99.30%
    Pyridoxal phosphate-d5 is the deuterium labeled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia.
    Pyridoxal phosphate-d<sub>5</sub>
  • HY-128736
    L-2-Phosphoglyceric acid
    L-2-Phosphoglyceric acid is an endogenous metabolite.
    L-2-Phosphoglyceric acid
  • HY-125818S1
    Cytidine-5′-triphosphate-d14 disodium
    		98.00%
    Cytidine-5′-triphosphate-d14 disodium is the deuterium labeled Cytidine-5'-triphosphate. Cytidine 5′-triphosphate (Cytidine triphosphate;5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
    Cytidine-5′-triphosphate-d<sub>14</sub> disodium
  • HY-113026S
    (2RS,4R,8R)-δ-Tocopherol-d4 (Mixture of Diastereomers)
    		99.54%
    (2RS,4R,8R)-δ-Tocopherol-d4 (Mixture of Diastereomers) is the deuterium labeled (2RS,4R,8R)-δ-Tocopherol (Mixture of Diastereomers).
    (2RS,4R,8R)-δ-Tocopherol-d<sub>4</sub> (Mixture of Diastereomers)
  • HY-W747907
    4-Pyridoxolactone
    		98.07%
    4-Pyridoxolactone (β-Pyracin) is a critical substrate in vitamin B6 degradation pathway I, primarily involved in the vitamin B6 metabolic process mediated by soil microorganisms. 4-Pyridoxolactone serves as the specific substrate for 4-pyridoxolactonase, undergoing a zinc-dependent lactone-ring hydrolysis reaction catalyzed by this enzyme to generate 4-pyridoxic acid (4PA).
    4-Pyridoxolactone
Cat. No. Product Name / Synonyms Application Reactivity
Endogenous Metabolite Isoform Comparison

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