Pyridoxal phosphate-d5
Based on 1 Customer Validation
Pyridoxal phosphate-d5 is the deuterium labeled Pyridoxal phosphate. Pyridoxal phosphate is the active form of vitamin B6, acts as an inhibitor of reverse transcriptases, and is used for the treatment of tardive dyskinesia.
For research use only. We do not sell to patients.
- Purity: 99.30%
- CAS No.: 1246818-16-5
- Formula: C8H5D5NO6P
- Molecular Weight:252.17
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1246818-16-5
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Unlabeled Cas 54-47-7
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Appearance Solid
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Molecular Weight 252.17
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Formula C8H5D5NO6P
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Color White to light yellow
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SMILES
C(OP(=O)(O)O)(C=1C(C=O)=C(O)C(C([2H])([2H])[2H])=NC1)([2H])[2H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 62.5 mg/mL (247.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71(1):180-7. [Content Brief]
[3]. Grin IR, et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9656 mL | 19.8279 mL | 39.6558 mL | 99.1395 mL |
| 5 mM | 0.7931 mL | 3.9656 mL | 7.9312 mL | 19.8279 mL | |
| 10 mM | 0.3966 mL | 1.9828 mL | 3.9656 mL | 9.9139 mL | |
| 15 mM | 0.2644 mL | 1.3219 mL | 2.6437 mL | 6.6093 mL | |
| 20 mM | 0.1983 mL | 0.9914 mL | 1.9828 mL | 4.9570 mL | |
| 25 mM | 0.1586 mL | 0.7931 mL | 1.5862 mL | 3.9656 mL | |
| 30 mM | 0.1322 mL | 0.6609 mL | 1.3219 mL | 3.3046 mL | |
| 40 mM | 0.0991 mL | 0.4957 mL | 0.9914 mL | 2.4785 mL | |
| 50 mM | 0.0793 mL | 0.3966 mL | 0.7931 mL | 1.9828 mL | |
| 60 mM | 0.0661 mL | 0.3305 mL | 0.6609 mL | 1.6523 mL | |
| 80 mM | 0.0496 mL | 0.2478 mL | 0.4957 mL | 1.2392 mL | |
| 100 mM | 0.0397 mL | 0.1983 mL | 0.3966 mL | 0.9914 mL |
Pyridoxal phosphate-d5 Related Classifications
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