3-Acetyldeoxynivalenol
Based on 1 Customer Validation
3-Acetyldeoxynivalenol (3-AcDON; 3ADON), a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative, is a brain-penetrant Fusarium mycotoxin. 3-Acetyldeoxynivalenol induces mRNA expression and production of inflammatory chemokine IL-8 in intestinal cells.
For research use only. We do not sell to patients.
- Purity: 98.38%
- CAS No.: 50722-38-8
- Formula: C17H22O7
- Molecular Weight:338.35
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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IL-8 |
3-Acetyldeoxynivalenol (0.1-10 μg/mL; 6 h) shows no significant cytotoxicity to human intestinal Caco-2 cells[1].
3-Acetyldeoxynivalenol (1 μg/mL; 1-6 h) is transported across human intestinal Caco-2 cell monolayers via a non-transporter-mediated passive paracellular route[1].
3-Acetyldeoxynivalenol (1 μg/mL; 6 h) reduces transepithelial electrical resistance in human intestinal Caco-2 cell monolayers[1].
3-Acetyldeoxynivalenol (0.5 μg/mL; 60 min) upregulates IL-8 gene expression by 2.0 to 2.1-fold in human intestinal Caco-2 cells[1].
3-Acetyldeoxynivalenol (0.1-1 μg/mL; 6-72 h) induces dose-dependent IL-8 secretion in human intestinal Caco-2 cells[1].
3-Acetyldeoxynivalenol (10 nM-10 μM; 48 h) does not reduce cellular viability of primary porcine brain capillary endothelial cells, but causes a significant increase in dehydrogenase activity at 10 μM[2].
3-Acetyldeoxynivalenol (10 μM; 48 h) causes a slight reduction in transendothelial electrical resistance of primary porcine brain capillary endothelial cell monolayers after 48 h incubation, indicating minor barrier integrity alterations[2].
3-Acetyldeoxynivalenol (10 μM; 48 h) does not cause a significant increase in 14C sucrose permeability across primary porcine brain capillary endothelial cell monolayers after 48 h incubation, indicating no meaningful barrier disruption[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human intestinal Caco-2 cells
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Concentration:0.1, 1, 10 μg/mL
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Incubation Time:6 h
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Result:Did not significantly reduce Caco-2 cell viability measured via MTS assay.
Did not induce LDH leakage into culture media.
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Cell Line:human intestinal Caco-2 cells
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Concentration:0.5 μg/mL
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Incubation Time:60 min
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Result:Induced a 2.0 to 2.1-fold upregulation of IL-8 gene expression compared to unexposed control cells.
Chemical Information
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CAS No. 50722-38-8
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Appearance Solid
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Molecular Weight 338.35
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Formula C17H22O7
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Color White to off-white
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SMILES
C[C@]1([C@@]([C@@H]2O)3CO)C[C@@H](OC(C)=O)[C@H]([C@@]14CO4)O[C@]3([H])C=C(C)C2=O
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Synonyms
3-AcDON; 3-ADON
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Structure Classification
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Initial Source
Aspergillus flavus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (279 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Kadota T, et al. Comparative study of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenol on intestinal transport and IL-8 secretion in the human cell line Caco-2. Toxicol In Vitro. 2013;27(6):1888-1895. [Content Brief]
[2]. Behrens M, et al. Blood-Brain Barrier Effects of the Fusarium Mycotoxins Deoxynivalenol, 3 Acetyldeoxynivalenol, and Moniliformin and Their Transfer to the Brain. PLoS One. 2015;10(11):e0143640. Published 2015 Nov 23. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3-Acetyldeoxynivalenol Related Classifications
HY-N6685 Related Classifications
Powered by Bioz
- 3-Acetyldeoxynivalenol
- 50722-38-8
- 3-AcDON
- 3-ADON
- Endogenous Metabolite
- Interleukin Related
- human intestinal Caco-2 cells
- IL-8
- Fusarium mycotoxin
- porcine brain capillary endothelial cells
- paracellular permeability
- blood-brain barrier
- deoxynivalenol
- transepithelial electrical resistance
- intestinal cells
- type B trichothecene
- Inhibitor
- inhibitor
- inhibit