2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Endogenous metabolites refer to the collective set of small-molecule chemical substances present within organelles, cells, organs, biological fluids, or entire organisms; their molecular weights are typically less than 1500 Da. These endogenous metabolites—including lipids, amino acids, short peptides, nucleic acids, carbohydrates, alcohols, and organic acids—not only participate in signal transduction governing genomic function but also receive upstream signals from the environment, thereby bridging the interrelationships among genotype, environment, and phenotype. Based on their biological functions, microbial endogenous metabolites can be broadly classified into two categories: primary metabolites and secondary metabolites. Primary metabolites are the core molecules essential for supporting microbial growth and proliferation; they serve to provide energy to the microbes or act as precursors and cofactors for the synthesis of biological macromolecules. In contrast, microbial secondary metabolites are a class of low-molecular-weight products that are not strictly essential for microbial growth. Nevertheless, microbial secondary metabolites include numerous substances—such as antibiotics, anti-tumor agents, and cholesterol-lowering agents—that are of critical importance to human health[1][2][3]. Furthermore, the metabolome of a biological organism is influenced by a variety of endogenous factors, including age, sex, body composition, genetic background, and underlying pathological states. The small-molecule metabolites within an organism are diverse and highly distinct; their levels are typically subject to the synergistic regulation of a vast array of enzymes and transport proteins, undergoing processes of synthesis, transformation, degradation, and compartmentalized distribution. Metabolomics research based on endogenous metabolites has been widely applied in the fields of metabolic disorders, neurodegenerative diseases, cancer, cardiovascular diseases, and infectious diseases, where these metabolites hold potential utility as biomarkers or therapeutic targets[1][2][3].

Endogenous Metabolite Isoform Specific Products:

Endogenous Metabolite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113252S1
    2-Methoxyestrone-13C6
    2-Methoxyestrone-13C6 is the 13C-labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.
    2-Methoxyestrone-<sup>13</sup>C<sub>6</sub>
  • HY-E70019
    alpha-2-3,6-sialidase (BiNanH2)
    alpha-2-3,6-sialidase (BiNanH2) is a sialyltransferase, is often used in biochemical studies. alpha-2-3,6-sialidase (BiNanH2) catalyzes α-2,3/2,6-sialyltransfer from CMP-Neu5Ac to galactoside acceptors.
    alpha-2-3,6-sialidase (BiNanH2)
  • HY-W010918S3
    Adenosine 5'-diphosphate-13C5
    Adenosine 5'-diphosphate-13C5 (Adenosine diphosphate-13C5) is the 13C-labeled Adenosine 5'-diphosphate (HY-W010918). Adenosine 5'-diphosphate (Adenosine diphosphate) is a nucleoside diphosphate. Adenosine 5'-diphosphate is the product of ATP dephosphorylation by ATPases. Adenosine 5'-diphosphate induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P2T-purinoceptors.
    Adenosine 5'-diphosphate-<sup>13</sup>C<sub>5</sub>
  • HY-130550
    (±)7(8)-EpDPA
    (±)7(8)-EpDPA is an epoxide derivative of docosahexaenoic acid (DHA) metabolized by CYP450.
    (±)7(8)-EpDPA
  • HY-E70893
    α-Lytic Protease M190A Mutant
    α-Lytic Protease is an alternative specificity protease for proteomics applications, whose wild-type (WT) version cleaves after T, A, S, and V residues. α-Lytic Protease M190A Mutant has different cleavage specificities, and cleaves after M, F, and L residues. Both the WT and M190A forms of aLP geneRate peptides of similar average length as trypsin.
    α-Lytic Protease M190A Mutant
  • HY-110382S
    Cyclic-di-GMP-13C20,15N10 disodium
    13C20,15N10-Cyclic di-GMP (13C20,15N10-c-di-GMP) is 13C and 15N labeled Cyclic-di-GMP (disodium). Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research.
    Cyclic-di-GMP-<sup>13</sup>C<sub>20</sub>,<sup>15</sup>N<sub>10</sub> disodium
  • HY-Z0792S
    4-O-Methyldopa-d3
    4-O-Methyldopa-d3 is deuterium labeled 4-O-Methyldopamine.
    4-O-Methyldopa-d<sub>3</sub>
  • HY-N15830
    Chenodeoxycholic acid 7-sulfate sodium
    Chenodeoxycholic acid 7-sulfate sodium, a bile acid, is a metabolite of Chenodeoxycholic acid (HY-76847).
    Chenodeoxycholic acid 7-sulfate sodium
  • HY-B1500R
    2,2,2-Trichloroethanol (Standard)
    2,2,2-Trichloroethanol (Standard) is the analytical standard of 2,2,2-Trichloroethanol. This product is intended for research and analytical applications. 2,2,2-Trichloroethanol, the active form of Chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4).
    2,2,2-Trichloroethanol (Standard)
  • HY-128738R
    Thymidine-5'-monophosphate disodium salt (Standard)
    Thymidine-5'-monophosphate (TMP) disodium salt (Standard) is the analytical standard of Thymidine-5'-monophosphate disodium salt (HY-128738). This product is intended for research and analytical applications. Thymidine-5'-monophosphate (TMP) disodium salt is a key nucleotide in pyrimidine metabolism, and its kinase activity can be competitively inhibited by 5'-fluorothymidine. The level of Thymidine-5'-monophosphate disodium salt is closely associated with acute kidney injury.
    Thymidine-5'-monophosphate disodium salt (Standard)
  • HY-W051723S2
    (R)-3-Hydroxybutanoic acid-d
    (R)-3-Hydroxybutanoic acid-d ((R)-(-)-3-Hydroxybutanoic acid-d) is the deuterium labeled (R)-3-Hydroxybutanoic acid (HY-W051723). (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones.
    (R)-3-Hydroxybutanoic acid-d
  • HY-181457
    1-Palmitoyl-2-9-OAHSA-3-oleoyl-sn-glycerol
    Palmitoyl-2-9-OAHSA-3-oleoyl-sn-glycerol (TG (16:0/9-OAHSA/18:1)) is a type of triacylglycerol that can be found in the lipid extract of mouse adipose tissue.
    1-Palmitoyl-2-9-OAHSA-3-oleoyl-sn-glycerol
  • HY-W009444S4
    5-Methyluridine-5′-13C
    5-Methyluridine-5′-13C is the 13C labeled 5-Methyluridine. 5-Methyluridine is a is an endogenous methylated nucleoside found in human flu.
    5-Methyluridine-5′-<sup>13</sup>C
  • HY-147406A
    Tonlamarsen sodium
    		Inhibitor
    Tonlamarsen sodium is a angiotensinogen synthesis reducer, with antihypertensive activity.
    Tonlamarsen sodium
  • HY-W483854
    N-Formyl-2-aminophenol
    		98.80%
    N-Formyl-2-aminophenol (N-(2-hydroxyphenyl)methanamide) is a bacterial secondary metabolite that has been found in P. chrysogenum and has antioxidant activity.
    N-Formyl-2-aminophenol
  • HY-113447S
    11-Dehydrocorticosterone-d10
    11-Dehydrocorticosterone-d10 is the deuterium labeled 11-Dehydrocorticosterone (HY-113447). 11-Dehydrocorticosterone is a endogenous corticosteroid. 11-Dehydrocorticosterone can be a source of transcriptionally active glucocorticoid in cardiac myocytes and fibroblasts. 11-Dehydrocorticosterone can increase SGK mRNA expression in cardiac fibroblast.
    11-Dehydrocorticosterone-d<sub>10</sub>
  • HY-N11200R
    3-Hydroxyisovalerylcarnitine (Standard)
    3-Hydroxyisovalerylcarnitine (Standard) is the analytical standard of 3-Hydroxyisovalerylcarnitine. This product is intended for research and analytical applications. 3-Hydroxyisovalerylcarnitine is a carnitine derivative. 3-Hydroxyisovaleryl carnitine in plasma may serve as a novel biomarker of biotin deficiency in humans, with its concentration increasing with biotin deficiency. Biotin deficiency reduces the activity of biotin-dependent 3-methylcrotonyl-CoA carboxylase, hinders the conversion of 3-methylcrotonyl-CoA into 3-methylglutaconyl-CoA, and impairs the leucine catabolism pathway; resulting in plasma 3-Hydroxyisovalerylcarnitine concentrations rise.
    3-Hydroxyisovalerylcarnitine (Standard)
  • HY-130440
    Leukotriene F4
    Leukotriene F4 (LTF4), is a lipid that belongs to the Cysteinyl Leukotriene (CysTL) family. Leukotriene F4 induces bronchoconstriction with an ED50 of 16 μg/kg. The precursor of LTF4 is Leukotriene E4 (LTE4), which isformed from the action of a glutamyl transferase.
    Leukotriene F4
  • HY-E70983
    Antistreptolysin O, Human
    Antistreptolysin O, Human is a hemolysin produced by group A streptococci. As a protein antigen, Antistreptolysin O, Human triggers an antibody response in the body.
    Antistreptolysin O, Human
  • HY-126700
    Sphaeropsidin B
    Sphaeropsidin B is a pimarane diterpene and phytotoxin. Sphaeropsidin B can be found in Diplodia cupressi and Diplodia corticola. Sphaeropsidin B induces phytotoxic effects in plants. Sphaeropsidin B can be used for the research of plant injury-related research areas.
    Sphaeropsidin B
Cat. No. Product Name / Synonyms Application Reactivity
Endogenous Metabolite Isoform Comparison

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