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Cat. No.: HY-113447S

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11-Dehydrocorticosterone-d₁₀

11-Dehydrocorticosterone-d₁₀ is the d₁₀-labeled 11-Dehydrocorticosterone (HY-113447). 11-Dehydrocorticosterone is an orally active 11β-HSD1 substrate and inactive glucocorticoid. 11-Dehydrocorticosterone is reduced by 11β-HSD1 to the active Corticosterone (HY-B1618). 11-Dehydrocorticosterone drives MR-dependent pro-inflammatory stimulation at low/moderate concentrations and GR-dependent suppression after conversion at high concentrations. 11-Dehydrocorticosterone increases Na,K-ATPase subunit mRNA/protein and pump activity in vascular smooth muscle and aorta. 11-Dehydrocorticosterone induces body weight gain, obesity, hyperinsulinemia, and insulin resistance, and inhibits hypothalamic-pituitary-adrenal axis activity. 11-Dehydrocorticosterone can be used in research on hypertension and metabolic syndrome.

For research use only. We do not sell to patients.

Formula: C₂₁H₁₈D₁₀O₄
Molecular Weight:354.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

11-Dehydrocorticosterone-d₁₀ Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 72-23-1
Molecular Weight 354.51
Formula C₂₁H₁₈D₁₀O₄
SMILES

O=C(C([2H])=C1C([2H])([2H])C[C@@]2([H])[C@]3([H])CC[C@]([2H])(C(C([2H])([2H])O)=O)[C@@]3(C)C4[2H])C([2H])([2H])C[C@]1(C)[C@@]2([2H])C4=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chantong B, et al. Mineralocorticoid and glucocorticoid receptors differentially regulate NF-kappaB activity and pro-inflammatory cytokine production in murine BV-2 microglial cells. Journal of neuroinflammation. 2012 Nov 28;9:260. [Content Brief]

[2]. Muto S, et al. Corticosterone and 11-dehydrocorticosterone stimulate Na,K-ATPase gene expression in vascular smooth muscle cells. Kidney international. 1998 Aug;54(2):492-508.

[3]. Seckl JR. 11β-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action?. Frontiers in neuroendocrinology. 1997 Jan 1;18(1):49-99.

[4]. Mitić T, et al. 11β-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto-and 7-hydroxy-oxysterols in vivo. Biochemical Pharmacology. 2013 Jul 1;86(1):146-53.

[5]. Brem AS, et al. 11-Dehydrocorticosterone, a glucocorticoid metabolite, inhibits aldosterone action in toad bladder. American Journal of Physiology-Renal Physiology. 1991 Nov 1;261(5):F873-9.

[6]. Sheppard KE, et al. 11β-Hydroxysteroid dehydrogenase 1 transforms 11-dehydrocorticosterone into transcriptionally active glucocorticoid in neonatal rat heart. Endocrinology. 2002 Jan 1;143(1):198-204. [Content Brief]

[7]. Sun J, et al. Taxifolin is a rat and human 11β-hydroxysteroid dehydrogenase 1 inhibitor as a possible drug to treat the metabolic syndrome. Journal of Functional Foods. 2018 Oct 1;49:181-7.

[8]. Harno E, et al. 11-Dehydrocorticosterone causes metabolic syndrome, which is prevented when 11β-HSD1 is knocked out in livers of male mice. Endocrinology. 2013 Oct 1;154(10):3599-609.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- Application
Chemical Information
Purity & Documentation
References

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11-Dehydrocorticosterone-d₁₀