72-23-1
72-23-1
Chemical Structure
11-Dehydrocorticosterone
- CAS No.: 72-23-1
- Formula:C21H28O4
- Molecular Weight:344.44
IUPAC Name: (8S,9S,10R,13S,14S,17S)-17-(2-hydroxyacetyl)-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-3,11(2H)-dione
InChIKey: FUFLCEKSBBHCMO-KJQYFISQSA-N
SMILES: C[C@@]1(C2)[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])C2=O)=O
Biological Activity: 11-Dehydrocorticosterone is a endogenous corticosteroid. 11-Dehydrocorticosterone can be a source of transcriptionally active glucocorticoid in cardiac myocytes and fibroblasts. 11-Dehydrocorticosterone can increase SGK mRNA expression in cardiac fibroblast[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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11-Dehydrocorticosterone | 96.87% | 11-Dehydrocorticosterone is a endogenous corticosteroid. 11-Dehydrocorticosterone can be a source of transcriptionally active glucocorticoid in cardiac myocytes and fibroblasts. 11-Dehydrocorticosterone can increase SGK mRNA expression in cardiac fibroblast. | ||||||||||||||||||||
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11-Dehydrocorticosterone-d10 | 11-Dehydrocorticosterone-d10 is the deuterium labeled 11-Dehydrocorticosterone (HY-113447). 11-Dehydrocorticosterone is a endogenous corticosteroid. 11-Dehydrocorticosterone can be a source of transcriptionally active glucocorticoid in cardiac myocytes and fibroblasts. 11-Dehydrocorticosterone can increase SGK mRNA expression in cardiac fibroblast. | |||||||||||||||||||||
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Deoxycorticosterone | 99.78% | Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor. Deoxycorticosterone is an agonist for O. mykiss mineralocorticoid receptor (rtMR) transcription with EC50 of 0.16 nM. Deoxycorticosterone could acts as an immune stimulator in fish. | ||||||||||||||||||||
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11-Ketotestosterone | 99.90% | 11-Ketotestosterone (11-Oxotestosterone), an oxidized form of Testosterone, is an active androgen. | ||||||||||||||||||||
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Cortisone | 99.34% | Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations. | ||||||||||||||||||||
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Cortisone-13C3 | Cortisone-13C3 is the 13C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations. | |||||||||||||||||||||
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Adrenosterone (Standard) | 98.58% | Adrenosterone (Standard) is the analytical standard of Adrenosterone. This product is intended for research and analytical applications. Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells. | ||||||||||||||||||||
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Corticosterone (Standard) | 99.70% | Corticosterone (Standard) is the analytical standard of Corticosterone. This product is intended for research and analytical applications. Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect. | ||||||||||||||||||||
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11-Ketoprogesterone | 98.44% | 11-Ketoprogesterone (11KP4) is the substrate for CYP17A1 and 11β-HSD2 that could be metabolized to 21-deoxycortisone (21dE) and 21-deoxycortisol (21dF) with glucocorticoid activity. | ||||||||||||||||||||
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18-Hydroxy-11-deoxy corticosterone | 18-Hydroxy-11-deoxy corticosterone (18-OH-DOC) is a mineralocorticoid whose synthesis is regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. 18-Hydroxy-11-deoxy corticosterone is an intermediate in the metabolism of progesterone and plays an important role in regulating blood pressure and water-salt balance. Continuous infusion of 18-Hydroxy-11-deoxy corticosterone can increase systolic blood pressure in rats, and plasma levels of 18-Hydroxy-11-deoxy corticosterone are significantly elevated in the db/db mouse model of type 2 diabetes, suggesting its potential involvement in metabolic dysregulation and diabetes-related regulation. 18-Hydroxy-11-deoxy corticosterone holds promise for research in areas such as hypertension, diabetes, and other related fields. | |||||||||||||||||||||
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21-Deoxy cortisone | 99.5% | 21-Deoxycortisone (21-Desoxycortisone; NSC 38722) is an endogenous C21 pregnane steroid metabolite. 21-Deoxycortisone is a substrate for 21-hydroxylation in calf adrenal glands and can be converted to Cortisone (HY-17461). 21-Deoxycortisone can be used for metabolism-related research. | ||||||||||||||||||||
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Testosterone impurity 1 | Testosterone impurity 1 is an impurity of Testosterone. | |||||||||||||||||||||
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