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NO Synthase

Nitric oxide synthases; NOS

NO Synthase

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Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.

NO Synthase Isoform Specific Products:

NO Synthase Isoform Comparison
Cat. No. Nombre del producto Efecto Pureza Chemical Structure
  • HY-146161
    COX-2/NO-IN-1
    		Inhibitor
    COX-2/NO-IN-1 is an orally active nitric oxide synthase (iNOS), COX-2 expression and NO (IC50 of 3.52 μM) inhibitor. COX-2/NO-IN-1 has anti-inflammatory effects.
    COX-2/NO-IN-1
  • HY-P3168
    Martentoxin
    		Inhibitor
    Martentoxin, a 4,046 Da polypeptide toxin, is a large-conductance Ca2+-activated K+ (BKCa) channel inhibitor. Martentoxin attenuates NO release, inhibits iNOS activation and upregulates eNOS mRNA expression in HUVECs induced by TNF-α. Martentoxin can be used for vascular diseases research.
    Martentoxin
  • HY-N0591R
    Dehydrocostus Lactone (Standard)
    		Inhibitor
    Dehydrocostus Lactone (Standard) ((-)-Dehydrocostus lactone (Standard)) is the analytical standard of Dehydrocostus Lactone (HY-N0591). This product is intended for research and analytical applications. Dehydrocostus Lactone is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells.
    Dehydrocostus Lactone (Standard)
  • HY-N3848
    Ermanin
    		Inhibitor 99.47%
    Ermanin is a flavonoid isolated from Tanacetum microphyllum. Ermanin potently inhibits iNOS, COX-2 activities, and inhibits platelet aggregation. Ermanin has anti-inflammatory, anti-tuberculous and anti-viral/bacterial properties.
    Ermanin
  • HY-119348
    Nitroparacetamol
    		Inhibitor
    Nitroparacetamol (NCX-701) is a nitric oxide (NO) donor-non-steroidal anti-inflammatory agent (NO-NSAID). Nitroparacetamol is formed by the ester linkage of Acetaminophen (HY-66005) and Nitrooxybutyroyl, aiming to combine the analgesic advantage of Acetaminophen with the organ-protective effect of nitric oxide, while expanding its anti-inflammatory activity. The analgesic spectrum of Nitroparacetamol is broader, and it is effective for painful pathological pain, and significantly reduces hepatotoxicity. Nitroparacetamol can reduce the expressions of IL-1β, TNF-α, COX-2, and iNOS.
    Nitroparacetamol
  • HY-N18117A
    23-Hydroxyohchininolide
    23-Hydroxyohchininolide is a limonoid found in the leaves of Melia azedarach L.. 23-Hydroxyohchininolide inhibits LPS (HY-D1056)-induced NO production and exerts cytotoxic activity against human leukemia and stomach cancer cells. 23-Hydroxyohchininolide inhibits TPA (HY-18739)-induced Epstein-Barr virus early antigen activation. 23-Hydroxyohchininolide can be used for the research of cancer, infection and inflammatory disease.
    23-Hydroxyohchininolide
  • HY-155821
    Anti-inflammatory agent 55
    		Inhibitor
    Anti-inflammatory agent 55 (compound 9j) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 0.8 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model.
    Anti-inflammatory agent 55
  • HY-153056
    BNN3
    		Activator 99.66%
    BNN3 is a caged nitric oxide (NO) donor. BNN3 is membrane-permeant and incorporated in the lipid membrane.
    BNN3
  • HY-107320
    Amtolmetin guacil
    		Activator 99.93%
    Amtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX). Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO). Amtolmetin guacil can be used to research knee osteoarthritis.
    Amtolmetin guacil
  • HY-156398
    Anti-inflammatory agent 60
    		Inhibitor
    Anti-inflammatory agent 60(compound 21) inhibitsnitric oxide production, with anIC50value of 12.95 μM.Anti-inflammatory agent 60reducesiNOS,phosphorylated p65, andβ-cateninexpression in a concentration-dependent manner.
    Anti-inflammatory agent 60
  • HY-181818
    4,5-Dehydro-6-oxoallosecurinine
    		Activator
    4,5-Dehydro-6-oxoallosecurinine is a Keap1-Nrf2 pathway activator. 4,5-Dehydro-6-oxoallosecurinine promotes the nuclear translocation of Keap1-Nrf2, and induces the expression of antioxidant and cytoprotective genes. 4,5-Dehydro-6-oxoallosecurinine reduces the production of NO, and decreases the levels of iNOS, TNF-α, IL-6 and IL-1β in LPS-stimulated microglia. 4,5-Dehydro-6-oxoallosecurinine can be used for the research of neurodegenerative diseases.
    4,5-Dehydro-6-oxoallosecurinine
  • HY-N19427
    25S-Anguivioside XV
    		Inhibitor
    25S-Anguivioside XV (Compound 8) is a steroidal glycoside. 25S-Anguivioside XV is isolated from the unripe berries of Solanum nigrum L. 25S-Anguivioside XV inhibits LPS-induced NO production with an IC50 of 49.35 μM. 25S-Anguivioside XV exhibits antiproliferative activity against hepatoma cells.
    25S-Anguivioside XV
  • HY-N15743
    Anti-Heart Failure Agent 2
    		Inhibitor
    Anti-Heart Failure Agent 2 (Compound 1) is an anti-heart failure agent with anti-inflammatory activity found in processed Cornus officinalis. Anti-Heart Failure Agent 2 inhibits NO release in LPS-induced RAW264.7 cells. Anti-Heart Failure Agent 2 alleviates myocardial ischemia-reperfusion injury, reduces myocardial infarction size, and improves myocardial histopathological changes. Anti-Heart Failure Agent 2 is promising for research of heart failure.
    Anti-Heart Failure Agent 2
  • HY-W750903
    Dihydroxanthohumol
    Dihydroxanthohumol is a chalcone found in Humulus lupulus L. Dihydroxanthohumol is a nitric oxide (NO) production inhibitor. Dihydroxanthohumol slightly suppresses LPS (HY-D1056)/IFN-γ-induced iNOS protein expression and NO production. Dihydroxanthohumol exhibits cytotoxicity at high concentrations.
    Dihydroxanthohumol
  • HY-P0132A
    YIGSR-Lys(N3)
    		Inhibitor
    YIGSR-Lys(N3) is a peptide that can inhibit the tumour growth and metastasis of leukaemic cells. YIGSR blocks the cellular binding to laminin I via a 67-kDa laminin-binding protein, and inhibits shear-induced increase in eNOS expression of laminin cells. YIGSR-Lys(N3) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    YIGSR-Lys(N3)
  • HY-N19813
    Flaccidoside VI
    		Inhibitor
    Flaccidoside VI is an inhibitor of nitric oxide production belonging to oleanane-type triterpenoid saponins. Flaccidoside VI can be isolated from the rhizomes of Anemone flaccida. Flaccidoside VI exhibits significant inhibitory activity against lipopolysaccharide-induced nitric oxide production.
    Flaccidoside VI
  • HY-N15513
    Harzianol M
    		Inhibitor
    Harzianol M is found in Trichoderma sp. SCSIOW21. Harzianol M can inhibit the production of NO and exhibit anti-inflammatory activity.
    Harzianol M
  • HY-182519
    HMN-1180
    		Inhibitor
    HMN-1180 is a selective, competitive neuronal nitric oxide synthase (nNOS) inhibitor with a Ki value of 5.4 μM against rat nNOS. HMN-1180 exerts no significant effect on endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). HMN-1180 inhibits nitric oxide production. HMN-1180 can be used for the study of nNOS-related neuronal functional physiology.
    HMN-1180
  • HY-149523
    Anticancer agent 157
    		Inhibitor
    Anticancer agent 157 (compound 15) is a NO inhibitor (IC50=0.62 μg/mL) with anti-inflammatory and anticancer activities. Anticancer agent 157 can bind to iNOS (inducible NO synthase) and caspase 8, causing nuclear fragmentation and chromatin condensation, inducing apoptosis. Anticancer agent 157 inhibits HT29 colon cancer cells (IC50=2.45 μg/mL), Hep-G2 liver cancer cells (IC50=3.25 μg/mL), and B16-F10 murine melanoma cells (IC50=3.84 μg/mL).
    Anticancer agent 157
  • HY-N1494
    (+)-14-Deoxy-ε-caesalpin
    		Inhibitor
    (+)-14-Deoxy-ε-caesalpin (14-Deoxy-ε-caesalpin), a cassane diterpenoid, inhibits nitric oxide (NO) production release of RAW 264.7 cells stimulated by Lipopolysaccharide (LPS).
    (+)-14-Deoxy-ε-caesalpin
Cat. No. Nombre del producto / Synonyms Application Reactivity
NO Synthase Isoform Comparison

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