Dihydroxanthohumol
Dihydroxanthohumol is a chalcone found in Humulus lupulus L. Dihydroxanthohumol is a nitric oxide (NO) production inhibitor. Dihydroxanthohumol slightly suppresses LPS (HY-D1056)/IFN-γ-induced iNOS protein expression and NO production. Dihydroxanthohumol exhibits cytotoxicity at high concentrations.
For research use only. We do not sell to patients.
- CAS No.: 102448-00-0
- Formula: C21H24O5
- Molecular Weight:356.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
74.41 μM
Compound: 4, alpha,beta-Dihydroxanthohumol
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Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay
Cytotoxicity against human HT-29 cells after 72 hrs by SRB assay
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[PMID: 23434138] |
| MCF7 | IC50 |
9.15 μM
Compound: 4, alpha,beta-Dihydroxanthohumol
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Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
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[PMID: 23434138] |
| PC-3 | IC50 |
14.73 μM
Compound: 4, alpha,beta-Dihydroxanthohumol
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Cytotoxicity against human PC3 cells after 72 hrs by SRB assay
Cytotoxicity against human PC3 cells after 72 hrs by SRB assay
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[PMID: 23434138] |
| RAW264.7 | IC50 |
23 μM
Compound: 3
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Inhibition of LPS/IFN-gamma-induced NO production in mouse RAW264.7 cells after 16 hrs
Inhibition of LPS/IFN-gamma-induced NO production in mouse RAW264.7 cells after 16 hrs
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[PMID: 15679315] |
Dihydroxanthohumol (Compound 5) (1-100 μg/mL; 16 h) inhibits LPS (HY-D1056)/IFN-γ-induced NO production in mouse macrophage RAW 264.7 cells, and slightly suppresses iNOS protein expression at 5 μg/mL[1].
Dihydroxanthohumol (10-100 μg/mL; 16 h) shows cytotoxicity to RAW 264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 cells
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Concentration:1, 5, 10, 50, 100 μg/mL
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Incubation Time:16 h
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Result:Showed cell viability <50% at 50, 100 μg/mL.
Showed cell viability <80% at 10 μg/mL.
Showed cell viability >95% at 50, 100 μg/mL.
Chemical Information
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CAS No. 102448-00-0
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Molecular Weight 356.41
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Formula C21H24O5
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SMILES
O=C(CCC1=CC=C(C=C1)O)C2=C(C(C/C=C(C)\C)=C(C=C2OC)O)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dihydroxanthohumol Related Classifications
HY-W750903 Related Classifications
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