23-Hydroxyohchininolide
23-Hydroxyohchininolide is a limonoid found in the leaves of Melia azedarach L.. 23-Hydroxyohchininolide inhibits LPS (HY-D1056)-induced NO production and exerts cytotoxic activity against human leukemia and stomach cancer cells. 23-Hydroxyohchininolide inhibits TPA (HY-18739)-induced Epstein-Barr virus early antigen activation. 23-Hydroxyohchininolide can be used for the research of cancer, infection and inflammatory disease.
For research use only. We do not sell to patients.
- CAS No.: 1429747-10-3
- Formula: C36H42O10
- Molecular Weight:634.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
23-Hydroxyohchininolide (Compound 8) (48 h) exhibits cytotoxic activity against HL60 leukemia cells (IC50 = 25.1 ± 3.2 μM) and AZ521 stomach cancer cells (IC50 = 78.5 ± 2.9 μM), but not against A549 lung or SK-BR-3 breast cancer cells (IC50 >100μM)[1].
23-Hydroxyohchininolide (2 h pre-incubation, then 16 h with LPS) inhibits LPS (HY-D1056)-induced NO production in RAW 264.7 macrophages with an IC50 of 58.6 ± 1.9 μM, and does not exhibit cytotoxicity against these cells at concentrations up to 100 μM[1].
23-Hydroxyohchininolide inhibits TPA (HY-18739)-induced EBV-EA activation in Raji cells with an IC50 of 497 molar ratio relative to 32 pmol TPA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL60 (leukemia), AZ521 (stomach), A549 (lung), SK-BR-3 (breast) human cancer cell lines
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Concentration:1×10-6 to 1×10-4 g/mL
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Incubation Time:48 h
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Result:Exhibited cytotoxicity against HL60 cells with an IC50 of 25.1 ± 3.2 μM.
Exhibited cytotoxicity against AZ521 cells with an IC50 of 78.5 ± 2.9 μM.
Showed no cytotoxicity (IC50 > 100 μM) against A549 and SK-BR-3 cells.
Chemical Information
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CAS No. 1429747-10-3
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Molecular Weight 634.71
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Formula C36H42O10
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SMILES
C[C@]12[C@@]3([H])[C@](OC[C@@]3([C@@H](C[C@@H]2OC(/C=C/C4=CC=CC=C4)=O)O)C)([H])[C@]5([H])[C@]([C@@H]1CC(OC)=O)(C6=C(C)[C@H](C7=CC(OC7=O)O)C[C@@]6([H])O5)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
23-Hydroxyohchininolide Related Classifications
HY-N18117A Related Classifications
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