23-Hydroxyohchininolide 

23-Hydroxyohchininolide is a limonoid found in the leaves of Melia azedarach L.. 23-Hydroxyohchininolide inhibits LPS (HY-D1056)-induced NO production and exerts cytotoxic activity against human leukemia and stomach cancer cells. 23-Hydroxyohchininolide inhibits TPA (HY-18739)-induced Epstein-Barr virus early antigen activation. 23-Hydroxyohchininolide can be used for the research of cancer, infection and inflammatory disease^[1].

23-Hydroxyohchininolide (Compound 8) (48 h) exhibits cytotoxic activity against HL60 leukemia cells (IC₅₀ = 25.1 ± 3.2 μM) and AZ521 stomach cancer cells (IC₅₀ = 78.5 ± 2.9 μM), but not against A549 lung or SK-BR-3 breast cancer cells (IC₅₀ >100μM)^[1].
23-Hydroxyohchininolide (2 h pre-incubation, then 16 h with LPS) inhibits LPS (HY-D1056)-induced NO production in RAW 264.7 macrophages with an IC₅₀ of 58.6 ± 1.9 μM, and does not exhibit cytotoxicity against these cells at concentrations up to 100 μM^[1].
23-Hydroxyohchininolide inhibits TPA (HY-18739)-induced EBV-EA activation in Raji cells with an IC₅₀ of 497 molar ratio relative to 32 pmol TPA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

634.71

C₃₆H₄₂O₁₀

1429747-10-3

C[C@]12[C@@]3([H])[C@](OC[C@@]3([C@@H](C[C@@H]2OC(/C=C/C4=CC=CC=C4)=O)O)C)([H])[C@]5([H])[C@]([C@@H]1CC(OC)=O)(C6=C(C)[C@H](C7=CC(OC7=O)O)C[C@@]6([H])O5)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pan X, et al. Cytotoxic and nitric oxide production-inhibitory activities of limonoids and other compounds from the leaves and bark of Melia azedarach. Chem Biodivers. 2014;11(8):1121-1139.  [Content Brief]