Phosphatase
Phosphatases are enzyme that remove a phosphate group from a protein. Protein tyrosine phosphatases (PTPs) comprise a diverse family of transmembrane and cytoplasmic enzymes. PTPs play an important role in regulating the proliferative activity of cells and the integrity of cell-cell and cell-matrix contacts. Protein tyrosine phosphatase 1B (PTP1B) is a non-receptor PTP frequently associated with the endoplasmic reticulum and vesicles subjacent to the plasma membrane. PTP1B as a key negative regulator of leptin receptor pathways has been an attractive therapeutic target for the treatment of type 2 diabetes mellitus and obesity. Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells. Three of these enzymes, PP1, PP2A, and PP2B, are members of the same gene family, while PP2C appears to be distinct.The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. Acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters following the general equation.
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Phosphatase Inhibitors
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Phosphatase Agonists
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Phosphatase Antagonists
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Phosphatase Activators
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Phosphatase Modulators
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Phosphatase Chemical
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Phosphatase Inducers
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Phosphatase Degraders
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Phosphatase Controls
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Phosphatase Substrates
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Phosphatase Ligands
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Phosphatase Proteins
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Phosphatase Related Products (729)
Related Products (729)
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Recombinant Proteins (66)
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Antibodies (40)
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Related Compound Screening Libraries (1)
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Questin
0 ImagesQuestin is an anthraquinone compound and antibacterial agent. Questin can be isolated from marine-derived fungi and plants. Questin inhibits Cdc25B phosphatase. Questin exhibits antibacterial activity against V. harveyi, V. anguillarum, V. cholerae, and V. parahemolyticus with MIC values of 31.25 µg/mL, 62.5 µg/mL, 62.5 µg/mL, and 125 µg/mL. Questin displays antiprotozoal activity against the animal protozoan pathogen Tritrichomonas foetus, with a MIC of 12.5 µg/mL. Questin has anticancer activity against lung and colon cancer.
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Cytostatin
0 ImagesCat. No.: HY-113612CAS No.: 682329-63-1Cytostatin is an effective and selective protein phosphatase 2A (PP2A) inhibitor with an IC50 value of 210 nM. Cytostatin exhibits anti-metastatic properties, good antitumor activity, and can induce apoptosis. Cytostatin can also prevent the adhesion of B16 melanoma cells to components of the extracellular matrix (laminin and collagen). Cytostatin belongs to the family of natural product fosriecin.
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TC-PTP-IN-1
0 ImagesCat. No.: HY-138964CAS No.: 1187396-28-6
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Tartaric acid disodium dihydrate (Standard)
0 ImagesSynonyms: Sodium tartrate dibasic dihydrate (Standard); Sodium tartrate dihydrate (Standard)Tartaric acid (disodium dihydrate) (Standard) is the analytical standard of Tartaric acid (disodium dihydrate). This product is intended for research and analytical applications. Tartaric acid disodium dehydrate (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. Tartaric acid disodium dehydrate has vasodilatory and antihypertensive effects. Tartaric acid disodium dehydrate can be used as flavorings and antioxidants in a range of foods and beverages. Tartaric acid disodium dehydrate can be used in laser frequency doubling and optical limiting applications[4].
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IONIS PTP1BRx sodium
0 ImagesCat. No.: HY-159694ASynonyms: ISIS 404173 sodiumIONIS PTP1BRx (ISIS 404173) sodium is an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). IONIS PTP1BRx sodium shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity.
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Luteolin 7-diglucuronide (Standard)
0 ImagesCat. No.: HY-N7269RCAS No.: 96400-45-2Luteolin 7-diglucuronide (Standard) is the analytical standard of Luteolin 7-diglucuronide. This product is intended for research and analytical applications. Luteolin 7-diglucuronide is the major flavonoid isolated from Aloysia triphylla and Verbena officinalis.
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4',7-Dihydroxy-3'-methoxyflavanone
0 ImagesCat. No.: HY-N18421CAS No.: 13192-07-94',7-Dihydroxy-3'-methoxyflavanone is a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with an IC50 of 98.1 μM against human targets. 4',7-Dihydroxy-3'-methoxyflavanone can be used in research related to type 2 diabetes and obesity.
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VHR-IN-4
0 ImagesCat. No.: HY-178294CAS No.: 1146616-15-0VHR-IN-4 (Compound SA7) is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 1.8 μM. VHR-IN-4 can be used for the research of cervical cancer.
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VHR-IN-8
0 ImagesCat. No.: HY-178303CAS No.: 1146616-19-4VHR-IN-8 (Compound SA8) is a selective vaccinia H1-related (VHR) phosphatase inhibitor with an IC50 of 2.4 μM. VHR-IN-8 can be used for the research of cervical cancer.
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VHR-IN-1
0 ImagesCat. No.: HY-128024CAS No.: 956189-91-6VHR-IN-1 (Compound SA1) is a potent and selective VHR phosphatase inhibitor with an IC50 of 18 nM. VHR-IN-1 can inhibit the proliferation of cervix cancer cells and has anti-tumor activity.
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CX08005
0 ImagesCat. No.: HY-117830CAS No.: 1256341-22-6CX08005 is a competitive PTP1B inhibitor. CX08005 can directly enhance the action of insulin in vivo and in vitro and improve insulin resistance.
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RMC-3943
0 ImagesCat. No.: HY-141524CAS No.: 1801764-60-2
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RRLIEDAEpYAARG
0 ImagesCat. No.: HY-P5447CAS No.: 118447-68-0RRLIEDAEpYAARG is a biological active peptide. (Phosphatase substrate.)
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PTP1B-IN-33
0 ImagesCat. No.: HY-181239CAS No.: 77500-30-2
![[pTyr5] EGFR (988-993) TFA](https://file.medchemexpress.com/product_pic/hy-p1799a.gif "Click to View [pTyr5] EGFR (988-993) TFA Product Detail")
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Dipsacus saponin XII
0 ImagesCat. No.: HY-N15231CAS No.: 149558-32-7Dipsacus saponin XII (compound 6) is a triterpenoid saponin that stimulates the proliferation of UMR106 cells and increases alkaline phosphatase activity in UMR106 cells (4 μM).
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D-erythro-Sphingosine-13C2,d2
0 ImagesCat. No.: HY-101047S1CAS No.: 2692623-81-5Synonyms: Erythrosphingosine-13C2,d2; erythro-C18-Sphingosine-13C2,d2; trans-4-Sphingenine-13C2,d2D-erythro-Sphingosine-13C2,d2 is a deuterated labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator.
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Phosphofructokinase,Bacillus stearothermophilus
0 ImagesPhosphofructokinase,Bacillus stearothermophilus is a glycolytic enzyme and also an allosteric activation target of fructose-2,6-bisphosphate. PFK1 supports cardiac glycolysis to maintain normal cardiac function and mediates adaptive responses to pressure overload. Upregulated expression and activity of PFK1 are associated with the alleviation of pathological changes induced by pressure overload, including diastolic dysfunction, interstitial fibrosis and myocardial hypertrophy. Inhibition of PFK1 redirects glucose carbon flux to the pentose phosphate pathway. PFK1 promotes proliferation, migration and glycolysis of colorectal cancer cells, reduces apoptosis and decreases their radiosensitivity, and shows higher expression levels in radioresistant tumors. PFK1 can be used in research related to diastolic dysfunction heart failure and colorectal cancer.
