2. Others Metabolic Enzyme/Protease
  3. Biochemical Assay Reagents Phosphatase
  4. Perfluoropentanesulfonic acid

Perfluoropentanesulfonic acid (PFPeS) is a per- and polyfluoroalkyl substance. Perfluoropentanesulfonic acid increases alkaline phosphatase (ALKP). Perfluoropentanesulfonic acid induces systemic toxicity in mouse models and alters the expression of genes related to fatty acid metabolism, inflammation and skin integrity in the liver and skin.

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Perfluoropentanesulfonic acid

Perfluoropentanesulfonic acid Chemical Structure

CAS No. : 2706-91-4

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Solvent
1 mg (28.56 mM * 100 μL in Ethanol) In-stock
Solvent
5 mg (28.56 mM * 500 μL in Ethanol) In-stock

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Perfluoropentanesulfonic acid Related Antibodies

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Description

Perfluoropentanesulfonic acid (PFPeS) is a per- and polyfluoroalkyl substance. Perfluoropentanesulfonic acid increases alkaline phosphatase (ALKP). Perfluoropentanesulfonic acid induces systemic toxicity in mouse models and alters the expression of genes related to fatty acid metabolism, inflammation and skin integrity in the liver and skin[1][2].

In Vivo

Perfluoropentanesulfonic acid (56-225 mg/kg; topical; daily; 28 days) results in dose-dependent systemic toxicity in female B6C3F1 mice, including significantly increased serum and urine PFPeS levels, up to 63% increased relative liver weight, 18% decreased relative spleen weight, altered serum chemistries, liver and skin histopathological changes, and immune cell population shifts, with greater potency observed at higher doses[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B6C3F1 mice (female, 7-8 weeks of age)[2]
Dosage: 56 mg/kg; 113 mg/kg; 225 mg/kg
Administration: topical; daily; 28 days
Result: Increased serum PFPeS concentrations to 41 μg/mL (56 mg/kg), 79.8 μg/mL (113 mg/kg), 119.2 μg/mL (225 mg/kg) relative to vehicle control.
Increased urine PFPeS concentrations to 220 μg/mL (56 mg/kg), 430 μg/mL (113 mg/kg), 470 μg/mL (225 mg/kg) relative to vehicle control.
Increased relative liver weights by 32% (56 mg/kg), 63% (113 mg/kg), and a greater magnitude (225 mg/kg) compared to vehicle controls.
Increased absolute liver weights significantly at all three doses compared to vehicle controls.
Decreased relative spleen weight by 18% at the 225 mg/kg dose compared to vehicle controls.
Increased serum glucose by 28% (56 mg/kg), 24% (113 mg/kg), and 25% (225 mg/kg) compared to vehicle controls.
Increased serum alkaline phosphatase (ALKP) by 47% at the 225 mg/kg dose compared to vehicle controls.
Induced minimal hepatocellular hypertrophy in 3/5 mice, mild hypertrophy in 1/5 mice (56 mg/kg); mild hypertrophy in all 5 mice (113 mg/kg); moderate hypertrophy in all 5 mice (225 mg/kg).
Induced minimal hepatocyte necrosis in 3/5 mice (113 mg/kg) and 2/5 mice (225 mg/kg).
Induced minimal epidermal hyperplasia in all 5 mice, minimal mixed cell inflammation in the dermis in 3/5 mice (225 mg/kg).
Molecular Weight

350.11

Formula

C5HF11O3S
CAS No.
Appearance

Liquid

SMILES

O=S(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Perfluoropentanesulfonic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Perfluoropentanesulfonic acid2706-91-4PFPeSBiochemical Assay ReagentsPhosphatasehuman serumper- and polyfluoroalkyl substancemiceliver damageliverskin integrityskinmurine modelsfatty acid metabolisminflammationInhibitorinhibitorinhibit

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