Cantharidic acid
Cantharidic acid is a selective inhibitor for protein phosphatase 2 (PP2A) and protein phosphatase 1 (PP1). Cantharidic acid inhibits cell viability and arrest cell cycle at sub G1 phase, induces apoptosis in cells NPC-39 and HONE-1 through the upregulation of ERK1/2, p38, and JNK1/2 pathway.
For research use only. We do not sell to patients.
- CAS No.: 28874-45-5
- Formula: C10H14O5
- Molecular Weight:214.22
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
218.5 μM
Compound: 4
|
Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
|
[PMID: 33454654] |
| HL-60 | IC50 |
103.2 μM
Compound: 4
|
Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Anticancer activity against human HL-60 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
|
[PMID: 33454654] |
| KB 3-1 | IC50 |
79.2 μM
Compound: 4
|
Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Anticancer activity against human KB 3-1 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
|
[PMID: 33454654] |
| leukaemia cell line | IC50 |
>50 μM
Compound: 4
|
Anticancer activity against human leukaemia cell line assessed as cell growth inhibition
Anticancer activity against human leukaemia cell line assessed as cell growth inhibition
|
[PMID: 33454654] |
Chemical Information
-
CAS No. 28874-45-5
-
Molecular Weight 214.22
-
Formula C10H14O5
-
SMILES
OC([C@@]([C@@]1(C)C(O)=O)([C@@H]2O[C@H]1CC2)C)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cantharidic acid Related Classifications
HY-137135 Related Classifications
Powered by Bioz