Cantharidic acid disodium
Based on 1 Customer Validation
Cantharidic acid disodium is the hydrolysis product of the acid anhydride Cantharidin that induces apoptosis in various human cancer cells. Cantharidic acid disodium is a selective protein phosphatase 2 (PP2A) and PP1 inhibitor withIC50 values of 50 nM and 600 nM, respectively.
For research use only. We do not sell to patients.
- Purity: 95%
- CAS No.: 1465-77-6
- Formula: C10H12Na2O5
- Molecular Weight:258.18
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Apoptosis Compound Library
HY-L003
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Anti-diabetic Compound Library
HY-L040
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HY-L081
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HY-L146
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Highly Selective Inhibitors Library
HY-L158
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Highly Selective Activators Library
HY-L159
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HY-L162
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HY-L001V
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HY-L196
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
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Biological Activity
Cantharidic acid (0-20 μM; 24 h) markedly reduces cell viability, which is revealed by the upregulation of caspase activation in extrinsic and intrinsic apoptosis pathways as well as the upregulation of ERK1/2, p38, and JNK1/2 pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HONE-1, NPC-39, and NPC-BM
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Concentration:0, 2.5 μM, 5 μM, 10 μM, or 20 μM
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Incubation Time:24 h
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Result:Markedly reduced cell viability.
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Cell Line:HONE-1, NPC-39
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Concentration:0, 2.5 μM, 5 μM, 10 μM
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Incubation Time:24 h
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Result:Led to apoptosis in human nasopharyngeal carcinoma (NPC) cells through the upregulation of caspase activation.
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Cell Line:HONE-1, NPC-39
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Concentration:0, 2.5 μM, 5 μM, 10 μM
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Incubation Time:24 h
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Result:Showed the upregulation of caspase activation in extrinsic and intrinsic apoptosis pathways as well as the upregulation of ERK1/2, p38, and JNK1/2 pathways.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1465-77-6
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Appearance Solid
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Molecular Weight 258.18
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Formula C10H12Na2O5
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Color White to off-white
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SMILES
O=C([C@@]([C@@]1(C)C(O[Na])=O)([C@@H]2O[C@H]1CC2)C)O[Na]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Yi-Ching Chen, et al. Cantharidic acid induces apoptosis in human nasopharyngeal carcinoma cells through p38-mediated upregulation of caspase activation. Environ Toxicol. 2020 May;35(5):619-627. [Content Brief]
[2]. Adam McCluskey, et al. Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem. 2002 Mar 14;45(6):1151-75. [Content Brief]
[3]. M J Graziano, et al. Comparison of the acute toxicity of endothal and cantharidic acid on mouse liver in vivo. Toxicol Lett. 1987 Jul;37(2):143-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cantharidic acid disodium Related Classifications
HY-137135A Related Classifications
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