Cantharidic acid disodium 

Cantharidic acid disodium is the hydrolysis product of the acid anhydride Cantharidin that induces apoptosis in various human cancer cells. Cantharidic acid disodium is a selective protein phosphatase 2 (PP2A) and PP1 inhibitor withIC₅₀ values of 50 nM and 600 nM, respectively^[1][2].

Cantharidic acid (0-20 μM; 24 h) markedly reduces cell viability, which is revealed by the upregulation of caspase activation in extrinsic and intrinsic apoptosis pathways as well as the upregulation of ERK1/2, p38, and JNK1/2 pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cantharidic acid (10 mg/kg; ip; once) causes extreme liver enlargement and congestion in mice. Hepatic glycogenolysis is increased as evidenced by elevations in blood glucose and hepatic glycogen phosphorylase levels and by corresponding reductions in hepatic glycogen content and glycogen synthase activity^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

258.18

C₁₀H₁₂Na₂O₅

1465-77-6

O=C([C@@]([C@@]1(C)C(O[Na])=O)([C@@H]2O[C@H]1CC2)C)O[Na]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yi-Ching Chen, et al. Cantharidic acid induces apoptosis in human nasopharyngeal carcinoma cells through p38-mediated upregulation of caspase activation. Environ Toxicol. 2020 May;35(5):619-627.  [Content Brief]

  [2]. Adam McCluskey, et al. Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem. 2002 Mar 14;45(6):1151-75.  [Content Brief]

  [3]. M J Graziano, et al. Comparison of the acute toxicity of endothal and cantharidic acid on mouse liver in vivo. Toxicol Lett. 1987 Jul;37(2):143-8.  [Content Brief]