28874-45-5
Chemical Structure
Cantharidic acid
- CAS No.: 28874-45-5
- Formula:C10H14O5
- Molecular Weight:214.22
IUPAC Name: (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
InChIKey: NMTNUQBORQILRK-XCVPVQRUSA-N
SMILES: OC([C@@]([C@@]1(C)C(O)=O)([C@@H]2O[C@H]1CC2)C)=O
Biological Activity: Cantharidic acid is a Cantharidin (HY-N0209) analog, anticancer agent, and selective Ser/thr phosphatase 1 and 2A inhibitor. Cantharidic acid induces ROS, Mitochondrial dysfunction, LDH release, cell cycle arrest, and Apoptosis. Cantharidic acid decreases Nrf2, HO-1, and GPX4, and reduces PCNA, MMP2, and MMP9. Cantharidic acid can be used in research on colorectal cancer, hepatocellular carcinoma, oral squamous cell carcinoma, and adenocarcinoma[1][2][3][4][5].
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Cantharidic acid | Cantharidic acid is a Cantharidin (HY-N0209) analog, anticancer agent, and selective Ser/thr phosphatase 1 and 2A inhibitor. Cantharidic acid induces ROS, Mitochondrial dysfunction, LDH release, cell cycle arrest, and Apoptosis. Cantharidic acid decreases Nrf2, HO-1, and GPX4, and reduces PCNA, MMP2, and MMP9. Cantharidic acid can be used in research on colorectal cancer, hepatocellular carcinoma, oral squamous cell carcinoma, and adenocarcinoma. | |||||||||||||||||||||
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References
- [1]. Wei Y, et al. Cantharidic acid causes mitochondrial dysfunction via the Nrf2/HO-1/GPX4 pathway to inhibit colorectal cancer progression. Histology and histopathology. 2026 Jul;41(7):1299-1316.
- [2]. Feng IC, et al. Cantharidic acid induces apoptosis through the p38 MAPK signaling pathway in human hepatocellular carcinoma. Environmental toxicology. 2018 Mar;33(3):261-268.
- [3]. Xi Y, et al. Cantharidins induce ER stress and a terminal unfolded protein response in OSCC. Journal of dental research. 2015 Feb;94(2):320-9.
- [4]. Sieder S, et al. Doxorubicin-resistant LoVo adenocarcinoma cells display resistance to apoptosis induction by some but not all inhibitors of ser/thr phosphatases 1 and 2A. Toxicology. 1999 Jun 15;134(2-3):109-15.
- [5]. Fan Y, et al. Cantharidin triggers cardiotoxicity via reactive anhydride-mediated covalent protein modification. Chemico-biological interactions. 2026 Oct 01;438:112299.
