Phospholipase A Inhibitor

Phospholipase A Inhibitors (49):

Cat. No.	Nom du produit	Effet	Pureté

HY-108609

YM-26734	Inhibitor	99.7%
YM-26734 is a competitive inhibitor of secretory phospholipase A² (PLA²) that exhibits a broad inhibitory profile to several PLA2s.

HY-116018

FKGK11	Inhibitor	99.9%
FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis.

HY-168765

LY433771	Inhibitor	99.8%
LY433771 (LSN433771) (Compound 8) is a type X secretory phospholipase A₂ (sPLA₂) inhibitor with an IC₅₀ value of 3 nM, which can be used in the study of cardiovascular diseases.

HY-134082A

(Z)-Oleyloxyethyl phosphorylcholine	Inhibitor	98.0%
(Z)-Oleyloxyethyl phosphorylcholine ((Z)-OPC) is an isomer of Oleyloxyethyl phosphorylcholine (OPC). Oleyloxyethyl phosphorylcholine is an inhibitor of secreted Phospholipase A2 (sPLA2), which is involved in the biosynthesis of proinflammatory lipid media. Oleyloxyethyl phosphorylcholine can be used to study inflammatory diseases. Oleyloxyethyl phosphorylcholine also modified the red blood membrane and was used to bind the oxygen-carrying liquid perfluorocarbons as an antivenom agent to reduce toxin-induced hemolysis.

HY-106253

Efipladib	Inhibitor
Efipladib is a potent, selective and orally active cPLA₂α inhibitor with an IC₅₀ of 0.04 μM and a K_d of 0.067 μM.

HY-120441

CAY10590	Inhibitor	98.0%
CAY10590 (GK115) is an inhibitor of secreted phospholipase A₂ (sPLA₂) and can be used for the research of chronic inflammatory kidney diseases.

HY-101015

(2E)-OBAA	Inhibitor
(2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC₅₀ of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca²⁺ influx in Trypanosoma brucei, with an IC₅₀ of 0.4 μM.

HY-120078

AZD2716	Inhibitor	99.9%
AZD2716 is a selective sPLA₂ (secretory phospholipase A2) inhibitor. AZD2716 significantly reduces the production of pro-inflammatory lipids by inhibiting sPLA₂-IIa (IC₅₀ = 10 nM), sPLA₂-V (IC₅₀ = 40 nM), and sPLA₂-X (IC₅₀ = 400 nM), thereby decreasing macrophage activation and foam cell formation. AZD2716 is promising for studying mechanisms related to atherosclerosis and inflammatory diseases associated with sPLA₂.

HY-133148

Lp-PLA2-IN-2	Inhibitor
Lp-PLA2-IN-2 is a potent and selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC₅₀ 0f 120 nM for recombinant human Lp-PLA2.

HY-162228

VI-60	Inhibitor
VI-60 is a dual, orally active inhibitor of cPLA₂ and COX-2, which reveals an anti-inflammtory efficacy through the inhibition of p38 MAPK/cPLA₂/COX-2/PGE₂ pathway.

HY-114873

LY256548	Inhibitor
LY256548 (LY25648) is an orally available anti-ischemic and anti-inflammatory compound with central nervous system activity. LY256548 is an inhibitor of phospholipase A2, 5-lipoxygenase (5-LOX), and COX, and inhibits A23187 (HY-N6687)-stimulated leukotriene B4 production. LY256548 inhibits bone damage and paw swelling in the rat Freund's complete adjuvant-induced arthritis (FCA) model.

HY-19415A

SB-435495 hydrochloride	Inhibitor
SB-435495 hydrochloride is a potent, selective, reversible, non-covalent and orally active Lp-PLA₂ inhibitor with an IC₅₀ of 0.06 nM.

HY-106555

Protizinic acid	Inhibitor
Protizinic acid is an orally active non-steroidal antiinflammatory agent with antiinflammatory and antipyretic activity. Protizinic acid inhibits phospholipase A2 (PLA2) activity, and the IC₅₀ value is 210 μM.

HY-N16481

Parameritannin A-1	Inhibitor
Parameritannin A-1 is a tetrameric proanthocyanidin (PAC) that can be isolated from the bark of Parameria laevigata Moldenke (Apocynaceae). Parameritannin A-1 is a COX-2 inhibitor. Parameritannin A-1 also inhibits the activity of phospholipase A₂ (PLA₂).

HY-112738

AX048	Inhibitor
AX048 is an inhibitor for calcium-dependent phospholipase A2 cPLA₂ with a X_I(50) of 0.022 mole fraction and reveals an antihyperalgesic efficacy.

HY-120621

BMS-229724	Inhibitor
BMS-229724 is an orally active and tight-binding cytosolic phospholipase A₂ (cPLA₂) inhibitor with an IC₅₀ of 2.8 μM. BMS-229724 can inhibit the production of arachidonic acid and eicosanoids in U937 cells, neutrophils, platelets, and other cells. BMS-229724 has anti-inflammatory activity and can be used in the research of diseases such as skin inflammation.

HY-119094

WAY-196025	Inhibitor
WAY-196025 is a selective and orally active indole cytosolic phospholipase A2 alpha (cPLA2α) inhibitor with an IC₅₀ of 0.01μM and a K_d of 0.013 μM. WAY-196025 can inhibit the production of prostaglandins (such as PGE2) and leukotrienes (such as LTB4), and reduce the release of inflammatory mediators. WAY-196025 can be used for the researches of inflammation and immunology, such as asthma.

HY-128762

ML256	Inhibitor
ML256 is a covalent lipoprotein-associated phospholipase A2 (Lp-PLA2 inhibitor. ML256 can be used for the study of neoplasms harboring a constitutively active variant of one or both of KRAS or HRAS.

HY-165327

AGN-190383	Inhibitor
AGN-190383 is a bee venom phospholipase A2 inhibitor. AGN 190383 inhibits both hormone-operated and depolarization-dependent calcium mobilization as well as fMLP stimulated increases in free cytosolic calcium. AGN-190383 has anti-inflammatory activity.

HY-108132

Ro 23-9358	Inhibitor
Ro 23-9358 is a potent secretory phospholipase A2 inhibitor with anti-inflammatory activity.

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