1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. Protizinic acid

Protizinic acid 

Cat. No.: HY-106555
Handling Instructions

Protizinic acid is an orally active non-steroidal antiinflammatory agent with antiinflammatory and antipyretic activity. Protizinic acid inhibits phospholipase A2 (PLA2) activity, and the IC50 value is 210 μM.

For research use only. We do not sell to patients.

Protizinic acid Chemical Structure

Protizinic acid Chemical Structure

CAS No. : 13799-03-6

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Description

Protizinic acid is an orally active non-steroidal antiinflammatory agent with antiinflammatory and antipyretic activity. Protizinic acid inhibits phospholipase A2 (PLA2) activity, and the IC50 value is 210 μM[1][2].

IC50 & Target[2]

PLA2

210 μM (IC50)

In Vitro

Protizinic acid not only inhibits the in vitro generation of leukokinin but also antagonizes to it on the receptor site of leukokinin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In vivo leukokinin (LK) generation system using feline acute ischemia model, When 3 mg/kg Protizinic acid is injected twice intravenously to cats with acute cardiac ischemia, increased blood acid protease activity is inhibited and significant inhibitory action on the decrease of leukokininogen, the precursor of leukokinin, is observed[1].
Oral administration of 30 mg/kg of Protizinic acid significantly inhibits arachidonic acid-induced erythema in guinea pigs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

315.39

Formula

C17H17NO3S

CAS No.
SMILES

CN1C2=C(C=CC(C(C)C(O)=O)=C2)SC3=CC(OC)=CC=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Protizinic acid
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HY-106555
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