AZD2716

Cat. No.: HY-120078 Purity: 99.9%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

AZD2716 is a selective sPLA₂ (secretory phospholipase A2) inhibitor. AZD2716 significantly reduces the production of pro-inflammatory lipids by inhibiting sPLA₂-IIa (IC₅₀ = 10 nM), sPLA₂-V (IC₅₀ = 40 nM), and sPLA₂-X (IC₅₀ = 400 nM), thereby decreasing macrophage activation and foam cell formation. AZD2716 is promising for studying mechanisms related to atherosclerosis and inflammatory diseases associated with sPLA₂.

For research use only. We do not sell to patients.

AZD2716 Chemical Structure

CAS No. : 1845753-81-2

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	Get quote	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

IC₅₀ & Target

sPLA2

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	176 nM Compound: (R)-7; AZD2716	Inhibition of sPLA2-2A production in human HepG2 cells Inhibition of sPLA2-2A production in human HepG2 cells	[PMID: 27774123]
HepG2	IC₅₀	< 14 nM Compound: (R)-7; AZD2716	Inhibition of sPLA2 in human HepG2 cells Inhibition of sPLA2 in human HepG2 cells	[PMID: 27774123]

Molecular Weight

373.44

Formula

C₂₄H₂₃NO₃

CAS No.

1845753-81-2

Appearance

Solid

Color

White to off-white

SMILES

NC(C1=C(C2=CC(C[C@@H](C)C(O)=O)=CC=C2)C=C(C=C1)CC3=CC=CC=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (26.78 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6778 mL	13.3890 mL	26.7781 mL
5 mM	0.5356 mL	2.6778 mL	5.3556 mL
10 mM	0.2678 mL	1.3389 mL	2.6778 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.9%

Select Batch:

Data Sheet (270 KB) SDS (392 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Karlsson S, et al. An enantioselective hydrogenation of an alkenoic acid as a key step in the synthesis of AZD2716[J]. Organic Process Research & Development, 2016, 20(2): 262-269.

[2]. Giordanetto F, et al. Discovery of AZD2716: A Novel Secreted Phospholipase A2 (sPLA2) Inhibitor for the Treatment of Coronary Artery Disease. ACS Med Chem Lett. 2016 Aug 9;7(10):884-889. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6778 mL	13.3890 mL	26.7781 mL	66.9452 mL
	5 mM	0.5356 mL	2.6778 mL	5.3556 mL	13.3890 mL
	10 mM	0.2678 mL	1.3389 mL	2.6778 mL	6.6945 mL
	15 mM	0.1785 mL	0.8926 mL	1.7852 mL	4.4630 mL
	20 mM	0.1339 mL	0.6695 mL	1.3389 mL	3.3473 mL
	25 mM	0.1071 mL	0.5356 mL	1.0711 mL	2.6778 mL

AZD2716 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD27161845753-81-2AZD 2716AZD-2716PhospholipaseInhibitorinhibitorinhibit

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AZD2716

AZD2716 Related Antibodies

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