1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. Lp-PLA2-IN-2

Lp-PLA2-IN-2 

Cat. No.: HY-133148
Handling Instructions

Lp-PLA2-IN-2 is a potent and selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.

For research use only. We do not sell to patients.

Lp-PLA2-IN-2 Chemical Structure

Lp-PLA2-IN-2 Chemical Structure

CAS No. : 2071636-15-0

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Description

Lp-PLA2-IN-2 is a potent and selective lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2[1].

IC50 & Target[1]

Lp-PLA2

120 nM (IC50)

In Vitro

Lp-PLA2-IN-2 inhibits Human Lp-PLA2 with an IC50 of 62 nM in PED6 assay[1].

In Vivo

Lp-PLA2-IN-2 (1 mg/kg; i.v.) treament in rats shows that the Cl, Vss and t1/2 values are 67 mL/min/kg, 1.2 L/kg, and 0.34 hours, respectively[1].

Animal Model: Male Han Wistar rats (250-300 g)[1]
Dosage: 1 mg/kg
Administration: i.v. (Pharmacokinetic Analysis)
Result: The Cl, Vss and t1/2 values were 67 mL/min/kg, 1.2 L/kg, and 0.34 hours, respectively.
Molecular Weight

394.46

Formula

C₁₉H₂₃FN₂O₄S

CAS No.

2071636-15-0

SMILES

N#CC1=CC(OCCN2C(C[[email protected]@H](C(CC3)(C)CCS3(=O)=O)C2)=O)=CC=C1F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Lp-PLA2-IN-2PhospholipaseLp-PLA2inflammationdiseaseslactamphospholipaseselectiveInhibitorinhibitorinhibit

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