2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. AX048

AX048 is an inhibitor for calcium-dependent phospholipase A2 cPLA2 with a XI(50) of 0.022 mole fraction and reveals an antihyperalgesic efficacy.

For research use only. We do not sell to patients.

AX048 Chemical Structure

AX048 Chemical Structure

CAS No. : 873079-69-7

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Description

AX048 is an inhibitor for calcium-dependent phospholipase A2 cPLA2 with a XI(50) of 0.022 mole fraction and reveals an antihyperalgesic efficacy[1].

IC50 & Target

cPLA2

 

In Vivo

AX048 (0-30 mg/kg, i.p.) reduces the thermal hyperalgesia with the ED50 of 1.2 mg/kg in Sprague Dawle rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Carrageenan-induced thermal hyperalgesia in Sprague Dawley rats[1]
Dosage: 0-30 mg/kg
Administration: i.p.
Result: Reduced the escape latencies in a dose-dependent manner.
Molecular Weight

383.57

Formula

C22H41NO4
CAS No.
SMILES

O=C(C(CCCCCCCCCCCCCC)=O)NCCCC(OCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AX048 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AX048873079-69-7AX 048AX-048PhospholipasehyperalgesiaInhibitorinhibitorinhibit

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