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Art. -Nr.: HY-112738

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AX048

Name: AX048
Brand: MedChemExpress
SKU: HY-112738
Price: 623.00 USD
Availability: InStock
Rating: 5 (1 reviews)

AX048 is an inhibitor for calcium-dependent phospholipase A2 cPLA₂ with a X_I(50) of 0.022 mole fraction and reveals an antihyperalgesic efficacy.

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CAS. Nr.: 873079-69-7
Formel: C₂₂H₄₁NO₄
Molecular Weight:383.57

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (262 KB)

AX048 Chemical Structure

CAS. Nr.: 873079-69-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

AX048 is an inhibitor for calcium-dependent phospholipase A2 cPLA₂ with a X_I(50) of 0.022 mole fraction and reveals an antihyperalgesic efficacy^[1].

IC₅₀ & Target

cPLA₂

Alle Phospholipase Isoform-spezifische Produkte anzeigen :

In Vivo

AX048 (0-30 mg/kg, i.p.) reduces the thermal hyperalgesia with the ED₅₀ of 1.2 mg/kg in Sprague Dawle rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Carrageenan-induced thermal hyperalgesia in Sprague Dawley rats^[1]
Dosage:

0-30 mg/kg
Administration:

i.p.
Result:

Reduced the escape latencies in a dose-dependent manner.

Chemical Information

CAS. Nr. 873079-69-7
Molecular Weight 383.57
Formel C₂₂H₄₁NO₄
SMILES

O=C(C(CCCCCCCCCCCCCC)=O)NCCCC(OCC)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yaksh TL, et al., Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. J Pharmacol Exp Ther. 2006 Jan;316(1):466-75. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biologische Aktivität
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- IC₅₀ & Target
- In Vivo
Chemical Information
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AX048

Alle Phospholipase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Beschreibung

IC50 & Target

In Vivo

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

AX048 Related Classifications

HY-112738 Related Classifications

Bioz

Keywords

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