Ras

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Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells. Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. As a result, mutations in ras genes can lead to the production of permanently activated Ras proteins. This can cause unintended and overactive signalling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRAS,KRAS, and NRAS) are the most common oncogenes in human cancer; Ras inhibitors are being studied as a treatment for cancer, and other diseases with Ras overexpression.

Ras Isoform Specific Products:

Ras Isoform Comparison

Ras Related Products (692)
Antibodies (36)
Ras Isoform Comparison

By Effects:	Inhibitors (565) Agonists (7) Degraders (31) Controls (9) Ligands (4) Antagonists (4) Activators (31) Modulators (6)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-162971

KRAS inhibitor-33	Inhibitor
KRAS inhibitor-33 (compound 115a) is an inhibitor of pyridopyrimidine kras (IC₅₀ ≤ 100nM).

HY-176870

KRAS-IN-42	Inhibitor
KRAS-IN-42 (Compound Z1063) is a covalent KRAS^G12D mutants inhibitor. KRAS-IN-42 is promising for research of KRAS^G12D-mutant cancers (e.g., non-small cell lung cancer, colorectal cancer).

HY-124514

UC-857993	Inhibitor
UC-857993 is a selective SOS1-Ras inhibitor (K_d=14.7 μM, His₆-SOS1_cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs).

HY-178978

α,δ-NAG	Activator
α,δ-NAG is an orally active glutaminase-resistant less-hydrolyzable L-Glutamine derivative. α,δ-NAG is a G protein-coupled receptor (GPCR) allosteric modulator. α,δ-NAG suppresses neutrophilic airway inflammation by activating the GPCR/ERK/MKP-1 pathway. α,δ-NAG can be used for the researches of inflammation and immunology, such as asthma.

HY-153555

KRAS G12D modulator-1	Modulator
KRAS G12D modulator-1 (compound 6) is a potent KRAS G12D modulator with IC₅₀ values of 1-10 μM for NEA-G12D, PPI-G12D, and p ERK-AGS, respectively. KRAS G12D modulator-1 can be used in research of cancer.

HY-142945

KRAS G12C inhibitor 43	Inhibitor
KRAS G12C inhibitor 43 (compound 59) is a potent KRAS G12C inhibitor. KRAS G12C inhibitor 43 shows antimigration and anti-proliferative activity with IC₅₀s of 0.001-1 µM, >1 µM, >1 µM for H358, A549, HCC cells ,respectively.

HY-170550

KRAS G12C inhibitor 69	Inhibitor
KRAS G12C inhibitor 69 (Compound K09) is the inhibitor for mutant RAS protein KRASG12C with an IC₅₀ of 4.36 nM. KRAS G12C inhibitor 69 inhibits the ERK phosphorylation in NCI-H358 and MIA-PACA-2 with an IC₅₀ of 12 nM and 7 nM. KRAS G12C inhibitor 69 inhibits the proliferation of cancer cell NCI-H358 and MIA-PACA-2 with IC₅₀ of 3.15 nM and 2.33 nM.

HY-173329

KRAS-IN-41	Inhibitor
KRAS-IN-41 is an inhibitor of KRAS with IC₅₀ values of <0.01 μM for KRAS G12D and KRAS G12V. KRAS-IN-41 inhibits RAS mutant cell lines, GP2D (KRAS-G12D) and SW620 (KRAS-G12V). KRAS-IN-41 can be used in cancer research.

HY-183645

KRAS G12C-IN-79	Inhibitor
KRAS G12C-IN-79 is a KRAS^G12C inhibitor with an IC₅₀ of 1.9 nM. KRAS G12C-IN-79 functionally inhibits the activity of the GDP-bound form of KRAS^G12C. KRAS G12C-IN-79 can be used for the research of nonsmall cell lung cancer, colon cancer, pancreatic cancer.

HY-186024

KRAS-IN-51	Inhibitor
KRAS-IN-51 (Compound 597a) is a KRas G12V inhibitor, with its IC₅₀ for KRas G12V being 2.9 nM; K_D values are 17 (at 20°C) and 68 (at 37°C) nM. KRAS-IN-51 inhibits the phosphorylation of pERK. KRAS-IN-51 has anti-proliferative activity against SW620 and MIAPaCa-2. KRAS-IN-51 can be used for research on colorectal cancer and pancreatic cancer.

HY-145047

SOS1-IN-4	Inhibitor
SOS1-IN-4 is a potent SOS1 inhibitor with an IC₅₀ of 56 nM for KRAS-C12C/SOS1 interaction (WO2021228028 A1, example 65).

HY-147631

KRAS G12C inhibitor 50	Inhibitor
KRAS G12C inhibitor 50 (Example 4) is a KRAS G12C inhibitor with an IC₅₀ of 46.7 nM.

HY-162440

pan-KRAS-IN-7	Inhibitor
pan-KRAS-IN-7 (Compound 25) is an inhibitor for in human tumor mutated genes KRAS, which inhibits proliferation of KRAS mutated cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with IC₅₀ of 0.35 and 0.51 nM, respectively.

HY-179253

KRAS-IN-47	Inhibitor
KRAS-IN-47 is a KRAS inhibitor with IC₅₀ < 50 nM against KRAS G12V. KRAS-IN-47 can be used for the study of cancers.

HY-172626

KRAS G12D inhibitor 28	Inhibitor
KRAS G12D inhibitor 28 (Compound 1) is a KRAS G12D inhibitor. KRAS G12D inhibitor 28 (Compound 1) can be used in the cancer research.

HY-163720

KRAS G12C inhibitor 63	Inhibitor
KRAS G12C inhibitor 63 (K45) is a KRAS G12C inhibitor. KRAS G12C inhibitor 63 can induce Apoptosis. KRAS G12C inhibitor 63 has antitumor activity.

HY-147636

KRAS G12C inhibitor 55	Inhibitor
KRAS G12C inhibitor 55 (Compound 1) is a KRAS G12C inhibitor.

HY-147632

KRAS G12C inhibitor 51	Inhibitor
KRAS G12C inhibitor 51 (example 1) is a KRAS G12C inhibitor.

HY-148878

Ras modulator-1	Modulator
Ras modulator-1 is a modulator of Ras. Ras modulator-1 is an active compound extracted from patent US20120302581.

HY-19315

SML-8-73-1	Inhibitor
SML-8-73-1 is a nucleotide-based KRAS^G12C inhibitor. SML-8-73-1 can be used for the study of non-small cell lung cancer (NSCLC).

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Ras

Ras

Ras Isoform Specific Products:

Ras Isoform Specific Products:

Ras Related Products (692)

Antibodies (36)

Ras Isoform Comparison

Ras Related Products (692):