1. Signaling Pathways
  2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. Toll-like Receptor (TLR) Inhibitors

Toll-like Receptor (TLR) Inhibitors

TLR3

TLR8

TLR9

TLR2

TLR4

TLR7

TLR1

TLR6

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Toll-like Receptor (TLR) Inhibitors, Agonists, Antagonists & Activators
Product Name TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6 Purity
Resatorvid        
TLR4
      99.95%
AT791    
TLR9, IC50: 0.04 μM
   
TLR7, IC50: 3.33 μM
    98.77%
TLR7/8-IN-1  
TLR8
     
TLR7
    99.80%
C29      
TLR2
        ≥98.0%
Imiquimod          
TLR7
    99.96%
Imiquimod hydrochloride          
TLR7
    99.80%
CU-T12-9      
TLR2, EC50: 52.9 nM (in HEK-Blue cells)
   
TLR1, EC50: 52.9 nM (in HEK-Blue cells)
  99.94%
Selgantolimod  
TLR8
            99.17%
Enpatoran hydrochloride  
TLR8, IC50: 24.1 nM
     
TLR7, IC50: 11.1 nM
    98.82%
DSR-6434          
TLR7, EC50: 7.2 nM (Human)
TLR7, EC50: 4.6 nM (Mice)
    99.49%
Isofraxidin        
TLR4
      98.14%
CU-CPT-8m  
TLR8, IC50: 67 nM
            99.98%
Sparstolonin B      
TLR2
TLR4
      ≥99.0%
IAXO-102        
TLR4
      ≥98.0%
1V209          
TLR7
    99.52%
CU-CPT-9a  
TLR8, IC50: 0.5 nM
            99.66%
Gardiquimod diTFA  
TLR8
     
TLR7
    ≥99.0%
GSK2245035          
TLR7
    99.79%
LHC-165          
TLR7
    98.17%
Neoseptin 3        
TLR4, EC50: 18.5 μM
      ≥98.0%
Robinin      
TLR2
TLR4
      ≥96.0%
CU-CPT17e
TLR3
TLR8
TLR9
          ≥98.0%
MMG-11 quarterhydrate      
TLR2
        ≥97.0%
FSL-1 TFA      
TLR2
     
TLR6
99.58%
CU-CPT9b  
TLR8, IC50: 0.7 nM
TLR8, Kd: 21 nM
            99.05%
Okanin        
TLR4
      ≥98.0%
Enpatoran  
TLR8, IC50: 24.1 nM (in HEK293 cells)
TLR8, IC50: 620 nM (in peripheral blood mononuclear cells (PBMCs))
TLR8, IC50: 120 nM ( in whole blood (WB) cells)
     
TLR7, IC50: 11.1 nM (in HEK293 cells)
TLR7, IC50: 68.3 nM (in peripheral blood mononuclear cells (PBMCs))
TLR7, IC50: 2.2 nM ( in whole blood (WB) cells)
    99.77%
CL264          
TLR7
    98.63%
TLR7 agonist 3          
TLR7
    98.35%
CU-115  
TLR8, IC50: 1.04 μM
     
TLR7, IC50: 50 μM
    98.10%
TLR7/8 agonist 3  
TLR8
     
TLR7
    99.02%
Polygalasaponin F        
TLR4
      ≥99.0%
MMG-11      
TLR2
       
Monophosphoryl lipid A        
TLR4
     
AXC-715 hydrochloride  
TLR8
     
TLR7
   
Imiquimod maleate          
TLR7
   
L48H37        
TLR4
     
TLR7 agonist 1          
TLR7, IC50: 90 nM
   
TLR8 agonist 2 hydrochloride  
TLR8, EC50: 3 nM
     
TLR7, EC50: 33.33 μM
   
TLR8 agonist 2  
TLR8, EC50: 3 nM
     
TLR7, EC50: 33.33 μM
   
TLR7/8 agonist 4  
TLR8
     
TLR7
   
Gardiquimod  
TLR8
     
TLR7
   
TLR4-IN-C34-C2-amide-C6-OH        
TLR4
     
Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH        
TLR4
     
BBIQ          
TLR7, EC50: 59.1 nM (Human TLR7)
   
Kdo2-Lipid A ammonium        
TLR4
     
FSL-1      
TLR2
     
TLR6
CAY10614        
TLR4, IC50: 1.675 μM (in HEK293 cells)
     
Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH        
TLR4
     
3M-011  
TLR8
     
TLR7
   
SM-324405          
human TLR7, pEC50: 7.3
Rat TLR7, pEC50: 6.6
TLR7, EC50: 50 nM
    98.24%
TLR3-IN-1
TLR3, IC50: 3.44 μM (in RAW 264.7 cells)