2. Signaling Pathways
  3. Anti-infection
  4. Beta-lactamase

Beta-lactamase

β-lactamase

Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.

Beta-lactamase Isoform Specific Products:

Beta-lactamase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0466R
    Cloxacillin sodium monohydrate (Standard)
    		Inhibitor
    Cloxacillin (sodium monohydrate) (Standard) is the analytical standard of Cloxacillin (sodium monohydrate). This product is intended for research and analytical applications. Cloxacillin sodium monohydrate is an orally active antibacterial agent and β-lactamase inhibitor with an IC50 of 0.04 μM. Cloxacillin sodium monohydrate can suppress the S. aureus-induced inflammatory response by inhibiting the activation of MAPKs, NF-кB and NLRP3-related proteins.
    Cloxacillin sodium monohydrate (Standard)
  • HY-139699
    GT-055
    		Inhibitor
    GT-055 (LCB18-055) is a novel broad-spectrum β-lactamase inhibitor.
    GT-055
  • HY-171112
    KSP-1007
    		Inhibitor
    KSP-1007 is a bicyclic boronate-based broad-spectrum β-lactamase inhibitor. KSP-1007 can effectively inhibit class A, B, C and D β-lactamases, including serine-type, metallo-type (such as NDM, VIM, IMP) and Acinetobacter baumannii OXA-type enzymes. KSP-1007 can enhance the antibacterial activity of Meropenem (HY-13678), reduce its MIC value, and be effective against carbapenemase-producing Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa. KSP-1007 can be used for the research of bacterial infection.
    KSP-1007
  • HY-105560
    Cefcanel
    		Substrate
    Cefcanel is an orally active cephalosporin and antibacterial agent. Cefcanel inhibits growth of methicillin-susceptible Staphylococcus aureus, methicillin-susceptible Staphylococcus epidermidis, Haemophilus influenzae, Moraxella catarrhalis. Cefcanel acts as a substrate hydrolyzed by TEM-1, TEM-3, and Moraxella Bro-1 beta-lactamases.
    Cefcanel
  • HY-144229
    trans-Cephalosporin
    		Inhibitor
    Trans substituted cephalosporin is an effective NDM-1 inhibitor，with an IC50 value of 0.13 μM.
    trans-Cephalosporin
  • HY-132824
    Ledaborbactam etzadroxil
    		Inhibitor
    Ledaborbactam etzadroxil (VNRX-7145) is an orally active Ambler class A, C, and D β-lactamase enzymes inhibitor.
    Ledaborbactam etzadroxil
  • HY-105284R
    Sulopenem (Standard)
    		Inhibitor
    N-Acetylneuraminic acid (Standard) is the analytical standard of N-Acetylneuraminic acid. This product is intended for research and analytical applications. N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia.
    Sulopenem (Standard)
  • HY-176565
    ZN148
    		Inhibitor
    ZN148 is a zinc-chelating synthetic metallo-β-lactamase (MBL) inhibitor which attenuates MBL-mediated carbapenem resistance. ZN148 can restore the in vitro clinical susceptibility to carbapenems in >98% of a large international collection of MBL-producing clinical Enterobacterales strains. ZN148 can be utilized in research on anti MBL-producing bacteria.
    ZN148
  • HY-146075
    β-Lactamase-IN-8
    		Inhibitor
    β-Lactamase-IN-8 (compound 20) is a potent and oral bioavailable broad-spectrum cyclic boronate β-lactamase inhibitor. β-Lactamase-IN-8 can be used for researching antibacteria.
    β-Lactamase-IN-8
  • HY-144100
    β-Lactamase-IN-7
    		Inhibitor
    β-Lactamase-IN-7 (compound 14) is a potent VIM-Type metallo-β-lactamase inhibitor, with Kis of 1.26 μM and 0.54 μM for VIM-1 and VIM-4, respectively. β-Lactamase-IN-7 can effectively inhibit Klebsiella pneumoniae.
    β-Lactamase-IN-7
  • HY-163382
    Cbz-Gly-Pro-Ala-O-cinnamyl
    		Inhibitor
    Cbz-Gly-Pro-Ala-O-cinnamyl (compound 25) is a small peptide targeting BACE-1 and AChE with the IC50 values of 0.02 μM and 1 μM, respectively. Cbz-Gly-Pro-Ala-O-cinnamyl shows neuroprotective effect and can be used for study of Alzheimer’s disease.
    Cbz-Gly-Pro-Ala-O-cinnamyl
  • HY-147349A
    Pilabactam
    		Inhibitor
    Pilabactam (ANT3310) is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC50 values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). Pilabactam potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam can be used in the research of bacterial infection.
    Pilabactam
  • HY-155504
    Metallo-β-lactamase-IN-11
    		Inhibitor
    Metallo-β-lactamase-IN-11 (compound 5f) is a Metallo-β-lactamases (MBLs) inhibitor, potent against bacterial metallophyllactamase CphA (IC50=45 µM). Metallo-β-lactamase-IN-11 (10 µM) inhibits NDM-1 by 49% and AIM-1 by 61%. Metallo-β-lactamase-IN-11 can be used in the research of inhibiting antibiotic resistance.
    Metallo-β-lactamase-IN-11
  • HY-139779
    β-Lactamase-IN-5
    		Inhibitor
    β-Lactamase-IN-5 is a β-lactamase inhibitor extracted from patent WO2013149121A1, compound 720. β-Lactamase-IN-5 can be used for the research of bacterial infections.
    β-Lactamase-IN-5
  • HY-115872
    β-Lactamase-IN-6
    		Inhibitor
    β-Lactamase-IN-6 is a β-Lactamase inhibitor that shows high antibacetrial activity.
    β-Lactamase-IN-6
  • HY-176519
    ANT2681
    		Inhibitor
    ANT2681 is a potent NDM inhibitor with a Ki value of 0.04 μM against NDM-1. ANT2681 also inhibits other MBLs, such as VIM-1 and IMP-1 with Ki values of 0.63 μM and 3.81 μM, respectively. ANT2681 can be used in combination with Meropenem (HY-13678) to inhibit infections caused by NDM-producing Enterobacteriaceae.
    ANT2681
  • HY-14879S7
    Avibactam-13C5,15N sodium
    Avibactam-13C5,15N sodium (NXL-104-13C5,15N sodium) is the 13C- and 15N-labeled Avibactam (HY-14879). Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively.
    Avibactam-<sup>13</sup>C<sub>5</sub>,<sup>15</sup>N sodium
  • HY-19647
    Ritipenem acoxil
    		Inhibitor
    Ritipenem acoxil (FCE 22891; RIPM-AC) is an oral active beta-lactamase antibiotic and can be used for study of bacterial pneumonia.
    Ritipenem acoxil
  • HY-178975
    β-Lactamase-IN-10
    		Inhibitor
    β-Lactamase-IN-10 (Compound CB1) is a dual-metal β-lactamase (MLB) and serine β-lactamase (SLB) inhibitor. β-Lactamase-IN-10 exhibits antibacterial (antibacterial) activity against various drug-resistant bacteria. β-Lactamase-IN-10 can be used in the research of Gram-negative superbug infections.
    β-Lactamase-IN-10
  • HY-178976
    YL6113
    		Inhibitor
    YL6113 is a potent and selective dual inhibitor of metallo-β-lactamases (MBLs) and serine-β-lactamases (SBLs). YL6113 shows inhibitory effect to MBLs, such as NDm-1, VIM-2, IMP-1, with IC50 values of 0.25, 27.16 and 3.55 μM. YL6113 shows inhibitory effect to SBLs, such as KPC-2, AmpC, OXA-48, with IC50 values of 0.2, 34.1 and 1.31 μM. YL6113 enhances the antibacterial efficacy of Meropenem (HY-13678) against carbapenem-resistant Gram-negative bacteria. YL6113 can be used for the research of infection.
    YL6113
Beta-lactamase Isoform Comparison

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